1999 Fiscal Year Final Research Report Summary
ESTIMATION OF PERIOPERATIVE CARDIAC FUNCTION FOLLOWING PEDIATRIC CARDIAC SURGERY USING NONINVASIVE MEASUREMENT OF HIGH FREQUENCY QRS POTENTIALS
| Project/Area Number |
10671239
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Department of Surgery, Institute of Clinical Medicine, University of Tsukuba |
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Principal Investigator |
ATSUMI Naotaka DEPARTMENT OF SURGERY, INSTITUTE OF CLINICAL MEDICINE, UNIVERSITY OF TSUKUBA ; ASSISTANT PROFESSOR, 臨床医学系, 講師 (00175176)
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| Project Period (FY) |
1998 – 1999
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| Keywords | high frequency QRS potentials / pediatric cardiac surgery / ischemic reperfusion / myocardial injury / cardiac function |
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| Research Abstract |
This study seeks to identify a new marker of intraoperative myocardial injury and perioperative cardiac function following pediatric cardiac surgery using high frequency QRS potentials.
1) High frequency QRS potentials and perioperative myocardial injury following cardioplegic arrest in pediatric cardiac surgery : Signal-averaged electrocardiograms were recorded during open heart operation in 14 pediatric patients. The high frequency QRS potentials decreased at early reperfusion following cardioplegic arrest and then returned to preischemic levels. The recovery time of high frequency QRS potentials significantly correlated with arrest time and the post operative CK-MB values. The results suggest that myocardial injury in pediatric cardiac surgery can be assessed by changes in the high frequency ECG signals of the QRS complex.
2) High frequency QRS potentials and the cardiac function. influence of hypoventilation : The changes in high frequency QRS potentials (RMS) and pressure volume relationship were studied in rat during hypoventilation. Emax, PRSW and RMS decreased during hypoventilation and returned during normal ventilation. There were good correlation between %RMS and %PRSW. The results suggest that decrease in cardiac function can be assessed by changes in RMS.
3) High frequency QRS potentials and the cardiac function. isolated rat heart of Langendorff perfusion : The changes in high frequency QRS potentials (RMS) and cardiac function were studied in isolated rat heart of Langendorff perfusion during post ischemic reperfusion period. Left ventricular dp/dt, heart rate, rate-pressure-product and RMS decreased at early reperfusion following cardioplegic arrest and then returned to preischemic levels. The results suggest that the recovery of cardiac function after post ischemic reperfusion period can be assessed by changes in RMS.
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