2001 Fiscal Year Final Research Report Summary
Chemical embolus therapy combined with hyperthermia for VX2 bone tumor in rabbits
Project/Area Number |
10671381
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Orthopaedic surgery
|
Research Institution | Kyorin University |
Principal Investigator |
MOCHIZUKI Kazuo Kyorin Univ. School of Med., Professor, 医学部, 教授 (70118892)
|
Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Hiroshi Kyorin Univ. School of Med., Assistant, 医学部, 助手
|
Project Period (FY) |
1998 – 2001
|
Keywords | Chemical embolus / Hyperthermia / Coarse crystal CDDP / VX2 bone tumor / Rabbits / Femur / Distal metaphysis / Histopathological findings |
Research Abstract |
The effect of chemical embolus therapy combined with hyperthermia was studied for the treatment of experimental malignant bone tumor in rabbits. Bone tumors were induced by transplanting VX2 tumor cells in suspension into the marrow of the distal femur. The rabbits were allocated to eight groups: a: untreated control, b: gelatin sponge embolus, c: coarse crystal CDDP embolus, d: hyperthermia, e: hyperthermia followed by gelatin sponge embolus, f: gelatin sponge embolus followed by hyperthermia, g: hyperthermia followed by coarse crystal CDDP embolus, h: coarse crystal CDDP embolus followed by hyperthermia. Animals in the eight groups were sacrificed and local antitumor effects and the inhibition of pulmonary metastasis was evaluated arid compared. The results showed that local antitumor effects and inhibition of pulmonary metastasis, as evaluated by all parameters, were significantly greater for Group (h) receiving the "coarse crystal CDDP embolus followed by hyperthermia" therapy. The synergistic effect of the combination of hyperthermia and chemical embolus therapy was demonstrated.
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Research Products
(8 results)