2001 Fiscal Year Final Research Report Summary
Biochemical analysis for the effect of mechanical stress on temporomandibular disorders
Project/Area Number |
10671863
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Kyusyu Dental College (2000-2001) Akita University (1998-1999) |
Principal Investigator |
TAKAHASHI Tetsu Kyusyu Dental College, School of Dentistry, Professor, 歯学部, 教授 (60226850)
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Project Period (FY) |
1998 – 2001
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Keywords | temporomandibular disorders / internal derangement / mechanical stress / synovial fluid / synovial fluid analysis / cytokine / nitric oxide / hyaluronic acid |
Research Abstract |
The purpose of this study is to biochemically analyze the levels of cytokines and nitric oxides in the synovial fluid from patients with patients with internal derangement of the temporomandibular joint, and to investigate the relationship between the mechanical stress such as bruxism and the levels of proinflammatory mediators in the synovial fluid. It was extremely difficult in synovial fluid sampling from the patients with internal derangement and bruxism. Therefore, we could not directly compare the levels of proinflammatory mediators and the presence of mechanical stress. However, We demonstrated that the synovial levels of protein were correlated with joint effusion. In addition, inducible nitric oxide synthase was expressed in the synovial lining cell layers in the synovium of the patients with temporomandibular diseases, not from the control patients. Furthermore, the molecular weight of the hyaluronic acid in the synovial fluid was decreased compared with that of the controls. These biochemical data strongly suggested that mechanical stress in involved in the pathogenesis of the temporomandibular joint diseases such as internal derangement.
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Research Products
(34 results)
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[Publications] Homma, H., Takahashi, T., Seki, H., Ohtani, M., Kondoh, T., and Fukuda, M.: "Immunohistochemical localization of inducible nitric oxide synthase in synovial tissue of human temporomandibular joints with internal derangement"Arch Oral Biol.. 46. 93-97 (2001)
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「研究成果報告書概要(欧文)」より
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[Publications] Toyosaki-Maeda, T., Takano, H., Tomita, T., Tsuruta, Y., Maeda-Tanimura, M., Shimaoka, Y., Takahashi, T., Itoh, T., Suzuki, R., and Ochi, T.: "Differentiation of monocytes into multinucleated giant bone-resorbing cells : two-step differentiation induced by nurse-like cells and cytokines"Arthritis Research. 3. 306-310 (2001)
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[Publications] Takahashi, T., Homma, H., Nagai, H., Seki, H., Kondoh, T., Yamazaki, Y., and Fukuda, M.: "Specific expression of inducible nitric oxide synthase in the synovium of the diseased temporomandibular joint"Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 95. 174-181 (2003)
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[Publications] Hamada, Y., Kondoh, T., Iino, M., Takahashi, T., Sekiya, H., Seto, K-I.: "Morphologic changes in the temporomandibular joint after release from mechanical load mandibulectomy"J Oral Maxillofac Surg. (in press). (2003)
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[Publications] Ohnuki, T., Fukuda, M., Seki, H., Miyoshi, K., Iino, M., Funaki, K., Takahashi, T.: "Evaluation of low signal intensity in the posterior disc attachment of temporomandibular joints revealed by MRI before and after arthroscopic lysis and lavage in patients with temporomandibular disorders"J. Jpn Soc. TMJ. 13. 334-339 (2001)
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[Publications] Ohnuki, T., Fukuda, M., Seki, H., Nara, J., lino, M., Funaki, K., Takahashi, T.: "Clinical study on MRI low signal intensity of posterior disc attachment in patients with closed lock"J. Jpn. Stomatol. Soc.. 51. 56-51 (2002)
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[Publications] Ohnuki, T., Fukuda, M., Seki, H., Funaki, K., lino, M.,Takahashi, T.: "Magnetic resonance evaluation of temporomandibular joint components in successfully treated cases of closed lock with a stuck disc"Jpn. J. Oral Maxillofac. Surg.. 48. 75-81 (2002)
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