2000 Fiscal Year Final Research Report Summary
Study on the muscle stiffness of forearm in normal and parkinsonian patients.
Project/Area Number |
10838014
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
リハビリテーション科学
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Research Institution | Shinshu University |
Principal Investigator |
HAYASHI Ryoichi Shinshu University, School of Allied Medical Sciences, Professor, 医療技術短期大学部, 教授 (40135215)
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Project Period (FY) |
1998 – 2000
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Keywords | aged contorts / neurological disorders / Parkinson's disease / LLR / EMG / muscles stiffness |
Research Abstract |
Objective : To study the effects of posteroventral pallidotomy on both the size of long-latency reflex(LLR)and the muscle stiffness in the wrist flexor muscles. Patients and Methods : Eleven consecutive patients(right-handed, 6 men and 5 women)underwent left-side microelectrode-guided pallidotomy. The LLR of the contralesional forearm was studied at baseline and 2-3 months after surgery while taking their optimal medical regimens("on" period). Patient were instructed not to response to the perturbation(passive mode)or to oppose to the mechanical extensor penurbation(active mode). Results : The stretch reflex evoked by extension perturbations of the wrist consisted of a shon-latency reflex(M1)and a long-latency reflex(M2). Pallidotomy had no effects on the size of M1 components in both passive and active mode and on that of M2 components in passive mode, however, reduced M2 components in active mode significantly(p<0.05). The inherent muscle stiffness over 60msec period of mechanical stretch was not affected by pallidotomy in any experimental condition(preoperative vs. postoperative, or passive mode vs. active mode). The hand displacement following M2 components increased significantly after pallidotomy in both passive(p<0.005)and active mode(p<0.05). The inverted value of the displacement followed M2 components correlated to the size of M2 components(r=0.6, p<0.0001). Conclusion : Pallidotomy had effects to decrease the transconical reflex gain, probably at the cortical level, and reduced consequently the muscle stiffness.
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Research Products
(22 results)