2001 Fiscal Year Annual Research Report

ヒトがんの環境・宿主要因に関する疫学的研究

Research Project

Project/Area Number	11181101
Research Institution	Aichi Cancer Center Research Institute
Principal Investigator	田島和雄愛知県がんセンター, 疫学・予防部, 部長 (30150212)
Co-Investigator(Kenkyū-buntansha)	中地敬放射線影響研究所, 疫学部, 部長 (00142117) 古野純典九州大学, 大学院・医学系研究科, 教授 (70128015) 大野良之名古屋大学, 医学部, 教授 (10160590) 鶴尾隆東京大学, 分子細胞生物学研究所, 教授 (00012667) 今井浩三札幌医科大学, 医学部, 教授 (60117603)
Keywords	民族疫学 / コーホート研究 / 症例対照研究 / 分子疫学 / 臨床疫学 / 危険・防御要因 / 遺伝子・環境交互作用
Research Abstract	本総括班はがんの疫学研究領域における5つの研究分野、1)国際比較による民族疫学的研究、2)要因解明を目指した大規模コーホート研究、3)発がん・予防に関する分析疫学的研究、4)環境発がんリスクの個体差を解明する分子疫学的研究、5)進展・予後に関する臨床疫学的研究、の特異性を活かしながら幅広い疫学研究を推進している。さらに、総括班のもとに二つの委員会、1)大規模コーホート研究運営委員会、2)分子疫学生体材料利用委員会、を設置し、各分野間で共有できる研究資料や生体材料の効率的運用を図り、それぞれの特異性にあった資材共同利用のための運営方法を検討している。今年度は大規模コーホート研究で収集された13,000検体の血清材料についてコーホート血清利用委員会でコンセンサスの得られた各種検査項目(SOD活性、IGF、sFas、TGF-β1)について一括測定を終了し、それらと生活習慣に関する調査結果を合わせ、全死亡と全がん死亡の要因、および肺がん、胃がんの危険・防御要因などの解析に活用した。また、分子疫学生体材料利用委員会では、国内の33施設で収集保存されているリンパ球(60,000検体)、DNA(15,000検体)、および鹿児島大学で保管されている世界19カ国から収集された生体材料(16,358個体)、などの具体的な利用方法について検討してきた。一方では、領域内で総括報告会を開催し、全分野の計画研究(22課題)や公募研究(22課題)の成果に関する相互情報交換、および各研究の問題点や研究協力の可能性などについて建設的な討議を行ってきた。さらに、がんの要因に関する遺伝子・環境交互作用を明らかにする分子疫学コーホートの設立、本邦に特異的なATLに関する包括的な研究を推進するための委員会の設立、ヒトを対象とした疫学・予防研究の成果の国民への伝達、など今後の重要課題についても検討してきた。

Research Products

(30 results)

All Other

All Publications (30 results)

[Publications] Matsuo, K.: "Association between folate and methionine related polymorphisms and malignant lymphoma risk"Blood. 97. 3205-3209 (2001)
[Publications] Takezaki, T.: "Dietary factors and lung cancer risk in Japanese : with special reference to fish consumption and adenocarcinomas"Brit. J. Cancer. 84(9). 1199-1206 (2001)
[Publications] Ohno, Y.: "Japan collaborative cohort study for evaluation of cancer risk sponsored by Monbusho (JACC Study)"J. Epidemiology. 11(4). 144-150 (2001)
[Publications] Xie, D.: "Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features"Cancer Res.. 61. 8917-8923 (2001)
[Publications] Imai, K.: "Personality types, lifestyle, and sensitivity to mental stress in association with NK activity"Int. J. Hygiene Environ.. 203. 1-7 (2001)
[Publications] Inoue, H.: "Glutathione S-transferase polymorphisms and risk of colorectal adenomas"Cancer Lett.. 163(2). 201-206 (2001)
[Publications] Kono, S.: "All epidemiological evidence is important in colorectal cancer"BMJ. 322(7286). 611 (2001)
[Publications] Adachi, Y.: "Expression of angiomodulin(tumor-derived adhesion factor/MCA25) in invading tumor cells correlates with poor prognosis in human colorectal cancer"Int. J. Cancer. 95. 216-222 (2001)
[Publications] Iwai, N.: "Validity and reliability of single item questions about physical activity"J. Epidemiol.. 11(5). 211-218 (2001)
[Publications] Yatsuya, H.: "Family history and the risk of stomach cancer death in Japan : Differences by age and gender"Int. J. Cancer. 97. 688-694 (2002)
[Publications] Nagata, C.: "Soy product intake and hotflashes in Japanese women : Results from a community-based prospective study"Am. J. Epidemiol.. 153. 790-793 (2001)
[Publications] Tokudome, S.: "Relative validity of a semi-quantitative food frequency questionnaire versus 28 day weighed diet records in Japanese female dietitians"Eur. J. Clin. Nutr.. 55. 735-742 (2001)
[Publications] Ito, Y.: "The effect of scrum carotenoids on atrophic gastritis among the inhabitants of a rural area in Hokkaido, Japan"Environ. Healthy Prev. Med.. 6(3). 184-188 (2001)
[Publications] Dakeishi, M.: "Genetic epidemiology of hereditary hemorrhagic telangiectasia in a local community in the northern part of Japan"Human Mutation. (In press).
[Publications] Ozasa, K.: "Dietary habit and risk of lung cancer death in a large-scale cohort (JACC Study) in Japan by sex and smoking habit"Jpn. J. Cancer Res.. 92(12). 1259-1269 (2001)
[Publications] Mizutani, Y.: "Prognostic significance of thymidylate synthase activity in bladder carcinoma"Cancer. 92. 510-518 (2001)
[Publications] Yamamoto, H.: "Clinicopathological and prognostic significance of matrilysin in expression at the invasive front in human colorectal cancers"Int. J. Cancer. 95(5). 290-294 (2001)
[Publications] Fujita, N.: "Involvement of Hsp90 in signaling and stability of 3-phsphoinositide-dependent kinase-1"J. Biol. Chem.. (In press).
[Publications] Fukui, Y.: "Hematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration"Nature. 412. 826-831 (2001)
[Publications] Takeuchi, K.: "Rapid decrease of EBV-infected cases among Japanese Hodgkin's diseases in recent decades"Brit. J. Hematol.. 113. 429-431 (2001)
[Publications] Sawano, A.: "Vascular endothelial growth factor receptor-1 (Flt-1) is a novel cell surface marker for the lineage of monocyte-macrophages in humans"Blood. 97. 785-791 (2001)
[Publications] Hanaoka, T.: "hOGG1 exon7 polymorphism and gastric cancer in case-control studies of Japanese and non-Japanese ethnic groups in Brazil"Cancer Lett.. 170. 53-61 (2001)
[Publications] Hara, M.: "Lifestyle-related risk factors for total and cancer mortality in men and women"Environ. Health Prev. Med.. 5. 111-117 (2001)
[Publications] Motohashi, Y.: "Reliability and validity of the questionnaire to determine the biosocial rhythms of daily living in the disabled elderly"J. Physiol. Anthropol.. 19. 263-269 (2001)
[Publications] Zaman, M.M.: "Angiotensin converting enzyme genetic polymorphism is not associated with hypertensin in a cross-sectional sample of a Japanese population : The Shibata study"J. Hypertens.. 19(1). 47-53 (2001)
[Publications] Fujino, Y.: "Job stress and mental health among permanent night workers"J. Occupational Health. 43(6). 301-306 (2001)
[Publications] Lee, G.H.: "Final chromosomal localization of the mouse Par2 gene that confers resistance against urethane-induction of pulmonary adenomas"Oncogene. 20. 3979-3985 (2001)
[Publications] Miyaki, M.: "Alteration of repeated sequence in 5' upstream and coding regions in colorectal tumors from patients with hereditary nonpolyosis colorectal cancer and Turcot syndrome"Oncogene. 20. 5215-5218 (2001)
[Publications] Kihara, C.: "Prediction of sensitivity of esophageal tumors to adjuvant chemotherapy by cDNA microarray analysis of gene-expression profiles"Cancer Res.. 61. 6474-6479 (2001)
[Publications] Yashiki, S.: "HLA-A^*26, HLA-B^*4002, HLA-B^*4006 and HLA-B^*4801 alleles predispose to asult T cell leukemia : The limited recognition of HTLV type I tax peptide anchor motif and epitope to generate anti-HTLV type I tax CD8+ cytotoxic T lymphocvtes"AIDS Res. Hum. Retrovirus. 17. 1047-1061 (2001)

2001 Fiscal Year Annual Research Report

ヒトがんの環境・宿主要因に関する疫学的研究

Principal Investigator

田島 和雄 愛知県がんセンター, 疫学・予防部, 部長 (30150212)

Research Products

[Publications] Matsuo, K.: "Association between folate and methionine related polymorphisms and malignant lymphoma risk"Blood. 97. 3205-3209 (2001)

[Publications] Takezaki, T.: "Dietary factors and lung cancer risk in Japanese : with special reference to fish consumption and adenocarcinomas"Brit. J. Cancer. 84(9). 1199-1206 (2001)

[Publications] Ohno, Y.: "Japan collaborative cohort study for evaluation of cancer risk sponsored by Monbusho (JACC Study)"J. Epidemiology. 11(4). 144-150 (2001)

[Publications] Xie, D.: "Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features"Cancer Res.. 61. 8917-8923 (2001)

[Publications] Imai, K.: "Personality types, lifestyle, and sensitivity to mental stress in association with NK activity"Int. J. Hygiene Environ.. 203. 1-7 (2001)

[Publications] Inoue, H.: "Glutathione S-transferase polymorphisms and risk of colorectal adenomas"Cancer Lett.. 163(2). 201-206 (2001)

[Publications] Kono, S.: "All epidemiological evidence is important in colorectal cancer"BMJ. 322(7286). 611 (2001)

[Publications] Adachi, Y.: "Expression of angiomodulin(tumor-derived adhesion factor/MCA25) in invading tumor cells correlates with poor prognosis in human colorectal cancer"Int. J. Cancer. 95. 216-222 (2001)

[Publications] Iwai, N.: "Validity and reliability of single item questions about physical activity"J. Epidemiol.. 11(5). 211-218 (2001)

[Publications] Yatsuya, H.: "Family history and the risk of stomach cancer death in Japan : Differences by age and gender"Int. J. Cancer. 97. 688-694 (2002)

[Publications] Nagata, C.: "Soy product intake and hotflashes in Japanese women : Results from a community-based prospective study"Am. J. Epidemiol.. 153. 790-793 (2001)

[Publications] Tokudome, S.: "Relative validity of a semi-quantitative food frequency questionnaire versus 28 day weighed diet records in Japanese female dietitians"Eur. J. Clin. Nutr.. 55. 735-742 (2001)

[Publications] Ito, Y.: "The effect of scrum carotenoids on atrophic gastritis among the inhabitants of a rural area in Hokkaido, Japan"Environ. Healthy Prev. Med.. 6(3). 184-188 (2001)

[Publications] Dakeishi, M.: "Genetic epidemiology of hereditary hemorrhagic telangiectasia in a local community in the northern part of Japan"Human Mutation. (In press).

[Publications] Ozasa, K.: "Dietary habit and risk of lung cancer death in a large-scale cohort (JACC Study) in Japan by sex and smoking habit"Jpn. J. Cancer Res.. 92(12). 1259-1269 (2001)

[Publications] Mizutani, Y.: "Prognostic significance of thymidylate synthase activity in bladder carcinoma"Cancer. 92. 510-518 (2001)

[Publications] Yamamoto, H.: "Clinicopathological and prognostic significance of matrilysin in expression at the invasive front in human colorectal cancers"Int. J. Cancer. 95(5). 290-294 (2001)

[Publications] Fujita, N.: "Involvement of Hsp90 in signaling and stability of 3-phsphoinositide-dependent kinase-1"J. Biol. Chem.. (In press).

[Publications] Fukui, Y.: "Hematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration"Nature. 412. 826-831 (2001)

[Publications] Takeuchi, K.: "Rapid decrease of EBV-infected cases among Japanese Hodgkin's diseases in recent decades"Brit. J. Hematol.. 113. 429-431 (2001)

[Publications] Sawano, A.: "Vascular endothelial growth factor receptor-1 (Flt-1) is a novel cell surface marker for the lineage of monocyte-macrophages in humans"Blood. 97. 785-791 (2001)

[Publications] Hanaoka, T.: "hOGG1 exon7 polymorphism and gastric cancer in case-control studies of Japanese and non-Japanese ethnic groups in Brazil"Cancer Lett.. 170. 53-61 (2001)

[Publications] Hara, M.: "Lifestyle-related risk factors for total and cancer mortality in men and women"Environ. Health Prev. Med.. 5. 111-117 (2001)

[Publications] Motohashi, Y.: "Reliability and validity of the questionnaire to determine the biosocial rhythms of daily living in the disabled elderly"J. Physiol. Anthropol.. 19. 263-269 (2001)

[Publications] Zaman, M.M.: "Angiotensin converting enzyme genetic polymorphism is not associated with hypertensin in a cross-sectional sample of a Japanese population : The Shibata study"J. Hypertens.. 19(1). 47-53 (2001)

[Publications] Fujino, Y.: "Job stress and mental health among permanent night workers"J. Occupational Health. 43(6). 301-306 (2001)

[Publications] Lee, G.H.: "Final chromosomal localization of the mouse Par2 gene that confers resistance against urethane-induction of pulmonary adenomas"Oncogene. 20. 3979-3985 (2001)

[Publications] Miyaki, M.: "Alteration of repeated sequence in 5' upstream and coding regions in colorectal tumors from patients with hereditary nonpolyosis colorectal cancer and Turcot syndrome"Oncogene. 20. 5215-5218 (2001)

[Publications] Kihara, C.: "Prediction of sensitivity of esophageal tumors to adjuvant chemotherapy by cDNA microarray analysis of gene-expression profiles"Cancer Res.. 61. 6474-6479 (2001)

田島和雄愛知県がんセンター, 疫学・予防部, 部長 (30150212)