2001 Fiscal Year Final Research Report Summary
ApoE and ApoE receptors modulate amylois deposition in Alzheimer's disease.
| Project/Area Number |
11670610
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAMBA Yoshio The University of Tokyo, Faculty of Medicine, Lecturer., 医学部・附属病院, 講師 (80228113)
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| Project Period (FY) |
1999 – 2001
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| Keywords | Alzheimer's disease / Apolipoprotein E / ApoE receptor / fatty acid |
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| Research Abstract |
The mechanisms by which the apolipoprotein E (apoE) influences Alzheimer's disease (AD) are not fully known. The apoE receptor family consists of cell-surface receptors that recognize extracellular ligande and internalize them for degradation by lysosomes. In order to gain insight about these receptors in the CNS, we raised a rabbit polyclonal antibody and examined immunohistochemically human brain tissue. The immunoreactivity was found in senile plaque in AD. These results may suggest a role of apoE receptor in amyloid formation.
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