The study on the effect of NMDA receptorantagonists on neuronal damage and neurotransmitter release

2001 Fiscal Year Final Research Report Summary

• Project/Area Number: 11671529
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kansai Medical University
• Principal Investigator: HIROSE Takaji Kansai Medical University,Faculty of medicine,Assistant professor, 医学部, 講師 (30189881)
• Co-Investigator(Kenkyū-buntansha): NAKAO Shinichi Kansai Medical University, Faculty of medicine, Associate professor, 医学部, 助教授 (10207714)
• Project Period (FY): 1999 – 2001
• Keywords: NMDA receptor / Microdialysis / Neurotransmitter / Dopamine / Nucleus accumbens / Posterior cingulate / Retrosplenial cortices

Research Abstract

Ketamine increased dopamine release in the nucleus accumbens, while pentobarbital decreased one. Furthermore, pentobarbital inhibited the ketamine-induced increase. Ketamine-induced c-Fos expression in the posterior cingulate cortex was inhibited by rimcazol but not by haloperidol, and was less in the NMDA receptor knockout mice.

Research Products

• [Publications] Kouhei Murao: "The anticonvulsant effects of volatile anesthetics on lidocaine-induced seizure in cats"Anesthesia Analgesia. 90. 142-147 (2000)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Nobuyasu Nishizawa: "The effects or ketamine isomers on mice benavior and c-Fos expression in the posterior cingulate cortex"Brain Research. 857. 188-192 (2000)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Atsushi Nagata: "Xenon inhibits but N_2O enhances ketamine-induced c-Foe expresicn in the rat posterior citigulate and retocsplenial cortices"Anesthesia Analgesia. 92. 362-368 (2001)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Etusko Miyamoto: "Caudoputamen is damaged by hypocapnia during mechanical ventilation in a rat model of chronic cerebral hypoperfusion"Stroke. 32. 2920-2925 (2001)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Nobuyasu Nishizawa: "Inhibition of the N-methyl-D-aspartate receptor channel by local anesthetics in mouse CAl pyramidal neurons"Anesthesia Analgesia. 94. 191-196 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Shinichi Nakao: "Ketamine-induced c-Fos expression in the mouse posterior cingulate and retrosplenial cortices is mediated not only via NMDA receptors but also sigma receptors"Brain Research. 926. 191-196 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Shinomura T, Nakao S, Adachi T, Shingu K.: "Clonidine inhibits and phorbol acetate activates glutamate release from rat spinal synaptoneurosomes."Anesthesia Analgesia. 88. 1401-1405 (1999)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Murao K, Singu K, Tsushima K, Takahira K, Ikeda S, Matsumoto H, Nakao S, Asai T.: "The anticonvulsant effects of volatile anesthetics on penicillin-induced status epiletious in cats."Anesthesia Analgesia. 90. 148-155 (2000)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Murao K, Singu K, Tsushima K, Takahira K, Ikeda S, Nakao S.: "The anticonvulsant effects of volatile on lidocaine-induced seizure in cats."Anesthesia Analgesia. 90. 142-147 (2000)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Nishizawa N, Nakao S, Nagata A, Hirose T, Shingu K.: "The effect of ketamine isomers on mice behavior and c-Fos expression in the posterior cingulate cortex."Brain Research. 857. 188-192 (2000)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Nagata A, Nakao S, Nishizawa N, Masuzawa M, Inada T, Murao K, Miyamoto E, Shingu K.: "Xenon inhibits but N2O enhances ketamine-induced c-Fos expression in the rat posterior cingulate and retrosplenial cortices."Anesthesia Analgesia. 92. 362-368 (2001)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Inada T, Taniuchi S, Shingu K, Kobayashi Y, Fujisawa J, Nakao S.: "Propofol depressed neutrophil hydrogen peroxide production more than midazolam, whereas adhesion molecule expression wasu minimally affected by both anesthetics in rats with abdominal sepsis."Anesthesia Analgesia. 92. 437-441 (2001)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Miyamoto E, Tomimoto H, Nakao S, Wakita H, Akiguchi I, Miyamoto K, Shingu K.: "Caudoputamen is damaged by hypocapnia during mechanical ventilation in a rat model of chronic cerebral hypoperfusion."Stroke. 32. 2920-2925 (2001)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Nishizawa N, O, Shirasaki T, Nakao S, Matsuda H, Shingu K.: "Inhibition of the N-methyl-D-aspartate receptor channel by local anesthetics in mouse CA1 pyamidal neurons."Anesthesia Analgesia. 94. 325-330 (2002)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Nakao S, Miyamoto E, Masuzawa M, Kambara T, Shingu K.: "Ketamine-induced c-Fos expression in the mouse posterior cingulate and retrosplenial cortices is mediated not only via NMDA receptors but also sigma receptors."Brain Research. 926. 191-196 (2002)
  • Description: 「研究成果報告書概要(欧文)」より