Non-invasive studies of sensorimotor integration in human

2002 Fiscal Year Final Research Report Summary

• Project/Area Number: 12210012
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: SHIBASAKI Hiroshi Kyoto University, Faculty of Medicine, Professor, 医学研究科, 教授 (30037444)
• Co-Investigator(Kenkyū-buntansha): FUKUYAMA Hidenao Kyoto University, Faculty of Medicine, Professor, 医学研究科, 教授 (90181297) ; KAJI Ryuji Tokushima University, University of Hospital, Professor, 医学部附属病院, 教授 (00214304) ; NAGAMINE Takashi Kyoto University, Faculty of Medicine, Associate Professor, 医学研究科, 助教授 (10231490) ; IKEDA Akio Kyoto University, Faculty of Medicine, Instructor, 医学研究科, 助手 (90212761) ; MIMA Tatsuya Kyoto University, Faculty of Medicine, Instructor, 医学研究科, 助手 (20324618)
• Project Period (FY): 2000 – 2002
• Keywords: electroencephalography / magnetoencephalography / functional MRI / transcranial magnetic stimulation / pain perception / involuntary movement / supplementary motor area / premotor area

Research Abstract

The purpose of our research project is to investigate the neural network integrating the sensory input from the external world and the motor act in human, by using the non-invasive techniques, such as electroencephalogram (EEG), magnetoencephalogram (MEG), functional MRI and transcranial magnetic stimulation (TMS). Additionally, when possible and ethically appropriate, we studied the invasive recording in human to advance the research project.
1. Cortical processing of pain perception
By using MEG source analysis, we found the importance of the primary sensory area for the pain perception in human. Our fMRI study showed the top-down control of pain perception is represented in the cingulated and second sensory areas.
2. Cerebral functional depression following the repetitive TMS (r-TMS)
Recently, it was shown that r-TMS can suppress the stimulated brain function transiently (virtual lesion study). By applying this new technique, we found the r-TMS over the primary sensory motor area can transiently suppress the tactile sensation.
3. Abnormal sensorimotor integration in patients with movement disorders
We found that the cortical mechanism of muscle relaxation is abnormal in patients with hand focal dystonia using fMRI. Clinical application of these new non-invasive neuroimaging technique would be promising.
4. Functional relevance of premotor and supplementary motor areas (PM and SMA) in motor control
By using the subdural recording in intractable epilepsy patients who is the candidate for the surgical treatment, we had the opportunity to record duthe epicortical EEG ring the task. We found that the voluntary movement can transiently increase the coherence between SMA and Ml and that the delayed reaction time task activates the PM and M1 successively.

Research Products

• [Journal Article] Second somatosensory area (Sll) plays a significant role in selective somatosensory attention (2002)
  • Author(s): Fujiwara, N. et al.
  • Journal Title: Brain Res Cogn Brain Res 14 Pages: 389-397
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The role of rostral Brodmann area 6 in mental-operation tasks : an integrative neuroimaging approach (2002)
  • Author(s): Hanakawa, T. et al.
  • Journal Title: Cereb Cortex 12 Pages: 1157-1170
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cortical motor mapping in epilepsy patients : information from subdural electrodes in presurgical evaluation (2002)
  • Author(s): Ikeda, A. et al.
  • Journal Title: Epilepsia 43 Pages: 56-60
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] "Supplementary motor area (SMA) seizure" rather than "SMA epilepsy" in optimal surgical candidates : a document of subdural mapping (2002)
  • Author(s): Ikeda, A. et al.
  • Journal Title: J Neurol Sci 202 Pages: 43-52
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cortical potentials related to assessment of pain intensity with visual analogue scale (VAS) (2002)
  • Author(s): Kanda, M. et al.
  • Journal Title: Clin Neurophysiol 113 Pages: 1013-1024
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Abnormal cortical mechanisms of voluntary muscle relaxation in patients with writer's cramp : an fMRI study (2002)
  • Author(s): Oga, T.et al.
  • Journal Title: Brain 125 Pages: 895-903
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Comparison of striatal dopamine D2 receptors in Parkinson's diseaseand progressive supranuclear palsy patients using [123I] iodobenzofuran single-photon emission computed tomography (2002)
  • Author(s): Oyanagi, C. et al.
  • Journal Title: J Neuroimaging 12 Pages: 316-324
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Partial epilepsy manifesting atonic seizure : report of two cases (2002)
  • Author(s): Satow, T. et al.
  • Journal Title: Epilepsia 43 Pages: 1425-1431
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Physiology of negative myoclonus (2002)
  • Author(s): Shibasaki, H.
  • Journal Title: Adv Neurol 89 Pages: 103-113
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Second somatosensory area (SII) plays a significant role in selective somatosensory attention (2002)
  • Author(s): Fujiwara, N., Imai, M., Nagamine, T., Mima, T., Oga, T., Takeshita, K., Toma, K., Shibasaki, H.
  • Journal Title: Brain Res Cogn Brain Res 14 (3) Pages: 389-97
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The role of rostral Brodmann area 6 in mental-operation tasks : an integrative neuroimaging approach (2002)
  • Author(s): Hanakawa.T., Honda, M., Sawamoto, N., Okada, T., Yonekura, Y., Fukuyama, H., Shibasaki, H.
  • Journal Title: Cereb Cortex 12 (11) Pages: 1157-70
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cortical motor mapping in epilepsy patients : information from subdural electrodes in presurgical evaluation (2002)
  • Author(s): Ikeda., A., Miyamoto, S., Shibasaki, H.
  • Journal Title: Epilepsia 43 Suppl 9 Pages: 56-60
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] "Supplementary motor area (SMA) seizure" rather than "SMA epilepsy" in optimal surgical candidates : a document of subdural (2002)
  • Author(s): Ikeda, A., Sato, T., Ohara., S., Matsuhashi, M., Yamamoto, J., Takayama.M., Matsumoto, R., Mikuni, N., Takahashi, J., Miyamoto, S., Taki, W., Hashimoto, N., Shibasaki, H.
  • Journal Title: J Neurol Sci 202 (1-2) Pages: 43-52
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cortical potentials related to assessment of pain intensity with visual analogue scale (VAS) (2002)
  • Author(s): Kanda, M., Matsuhashi, M., Sawamoto, N., Oga, Mima, T., Nagamine, T., Shibasaki, H.
  • Journal Title: Clin. Neurophysiol 113 (7) Pages: 1013-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Abnormal cortical mechanisms of voluntary muscle relaxation in patients with writer's cramp : an fMRI study (2002)
  • Author(s): Oga, T., Honda, M., Toma, K., Murase, N., Okada, T., Hanakawa, T., Sawamoto, N., Nagamine, T., Konishi, J., Fukuyama, H., Kaji, R., Shibasaki, H.
  • Journal Title: Brain 125 (Pt 4) Pages: 895-903
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparison. of striatal dopamine D2 receptors in Parkinson's disease and progressive supranuclear palsy patients using [1231] lodobenzofuran single-photon emission computed tomography (2002)
  • Author(s): Oyanagi, C., Katsumi, Y., Hanakawa, T., Hayashi., T., Thuy, D.D., Hashikawa, K., Nagahama, Y., Fukuyama, H., Shibasaki, H.
  • Journal Title: J Neuroimaging 12 (4) Pages: 316-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Partial epilepsy manifesting atonic seizure : report of two cases (2002)
  • Author(s): Satow, T., Ikeda, A., Yamamoto, J., Takayama, M., Matsuhashi, M., Ohara, S., Matsumoto, R., Begum, T., Fukuyama, H., Hashimoto, N., Shibasaki, H.
  • Journal Title: Epilepsia 43 (11) Pages: 1425-31
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional mapping of human medial frontal motor areas. The combined use of functional magnetic resonance imaging and cortical stimulation (2001)
  • Author(s): Hanakawa, T. et al.
  • Journal Title: Exp Brain Res 138 Pages: 403-409
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Asymmetric tonic seizures with bilateral parietal lesions resembling frontal lobe epilepsy (2001)
  • Author(s): Ikeda, A. et al.
  • Journal Title: Epileptic Disord 3 Pages: 17-22
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Dissociable mechanisms of attentional control within the human prefrontal cortex (2001)
  • Author(s): Nagahama, Y. et al.
  • Journal Title: Cereb Cortex 11 Pages: 85-92
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Increased synchronization of cortical oscillatory activities between human supplementary motor and primary sensorimotor areas during voluntary movements (2001)
  • Author(s): Ohara, S. et al.
  • Journal Title: J Neurosci 21 Pages: 9377-9386
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Functional mapping of human medial frontal motor areas. The combined use of functional magnetic resonance (2001)
  • Author(s): Hanakawa, T., Ikeda, A., Sadato, N., Okada, T., Fukuyama, H., Nagamine, T., Honda, M., Sawamoto, N., Yazawa, S., Kunieda, T., Ohara., S., Taki, W., Hashimoto, N., Yonekura, Y., Konishi, J., Shibasaki, H.
  • Journal Title: Exp Brain Res 138 (4) Pages: 403-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Asymmetric tonic seizures with bilateral parietal lesions resembling frontal lobe epilepsy (2001)
  • Author(s): Ikeda., A., Matsumoto, R., Ohara, S., Kunieda, T., Shirakashi, Y., Kaji, R., Fukuyama, H., Shibasaki, H.
  • Journal Title: Epileptic Disord 3 (1) Pages: 17-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dissociable mechanisms of attentional control within the human prefrontal cortex (2001)
  • Author(s): Nagahama, Y., Okada, T., Katsumi, Y., Hayashi, T., Yamauchi, H., Oyanagi, C., Konishi, J., Fukuyama, H., Shibasaki, H.
  • Journal Title: Cereb Cortex 11 (1) Pages: 85-92
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Increased synchronization of cortical oscillatory activities between human supplementary motor and primary sensorimotor (2001)
  • Author(s): Ohara, S., Mima, T., Baba, K., Ikeda, A., Kunieda., T., Matsumoto, R., Yamamoto, J., Matsuhashi, M., Nagamine, T., Hirasawa, K., Hori, T., Mihara, T., Hashimoto, N., Salenius, S., Shibasaki, H.
  • Journal Title: Neurosci 21 (23) Pages: -9377-86
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Essential role of the right superior parietal cortex in Japanese kana mirror reading : An fMRI study (2000)
  • Author(s): Dong, Y. et al.
  • Journal Title: Brain 123 Pages: 790-799
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Carotid brainstem reflex myoclonus after hypoxic brain damage (2000)
  • Author(s): Hanakawa, T. et al.
  • Journal Title: J Neurol Neurosurg Psychiatry 69 Pages: 672-674
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of primary sensorimotor cortices in generating inhibitory motor response in humans (2000)
  • Author(s): Ikeda, A. et al.
  • Journal Title: Brain 123 Pages: 1710-1721
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Autosomal dominant temporal lobe epilepsy in a Japanese family (2000)
  • Author(s): Ikeda, A. et al.
  • Journal Title: J Neurol Sci 176 Pages: 162-165
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Activity-dependent conduction block in multifocal motor neuropathy (2000)
  • Author(s): Kaji, R. et al.
  • Journal Title: Brain 123 Pages: 1602-1611
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Primary somatosensory cortex is actively involved in pain processing in human (2000)
  • Author(s): Kanda, M. et al.
  • Journal Title: Brain Res 853 Pages: 282-289
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Glucose metabolism in the rat frontal cortex recovered without the recovery ofcholine acetyltransferase activity after lesioning of the nucleus basalis magnocellularis (2000)
  • Author(s): Katsumi, Y. et al.
  • Journal Title: Neurosci Lett 280 Pages: 9-12
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Different activation of presupplementary motor area, supplementary motor area proper, and primary sensorimotor area, depending on the movement repetition rate in humans (2000)
  • Author(s): Kunieda, T. et al.
  • Journal Title: Exp Brain Res 135 Pages: 163-172
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Use of cavernous sinus EEG in the detection of seizure onset andspread in mesial temporal lobe epilepsy (2000)
  • Author(s): Kunieda, T. et al.
  • Journal Title: Epilepsia 41 Pages: 1411-1419
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Vascular cell components of the medullary arteries in Binswanger's disease brains : a morphometric and Immunoelectron microscopic study (2000)
  • Author(s): Lin, J.X.etal.
  • Journal Title: Stroke 31 Pages: 1838-1842
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nonconvulsive focal inhibitory seizure : subdural recording from motor cortex (2000)
  • Author(s): Matsumoto, R. et al.
  • Journal Title: Neurology 55 Pages: 429-431
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nicotine-sensitive writer's cramp (2000)
  • Author(s): Murase, N. et al.
  • Journal Title: Mov Disord 15 Pages: 1276-1279
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Abnormal premovement gating of somatosensory input in writer'scramp (2000)
  • Author(s): Murase, N. et al.
  • Journal Title: Brain 123 Pages: 1813-1829
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Attentional modulation of parieto-occipital cortical responses : implications for hemispatial neglect (2000)
  • Author(s): Nakamura, K. et al.
  • Journal Title: J Neurol Sci 176 Pages: 136-143
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Implication of sensorimotor integration in the generation of periodic dystonic myoclonus in subacute sclerosing panencephalitis (SSPE) (2000)
  • Author(s): Oga, T.et al.
  • Journal Title: Mov Disord 15 Pages: 1173-1183
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Electrocorticogram-electromyogram coherence during isometric contraction of hand muscle in human (2000)
  • Author(s): Ohara, S. et al.
  • Journal Title: Clin Neurophysiol 111 Pages: 2014-2024
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Movement-related change of electrocorticographic activity in human supplementary motor area proper (2000)
  • Author(s): Ohara, S. et al.
  • Journal Title: Brain 123 Pages: 1203-1215
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expectation of pain enhances responses to nonpainful somatosensory stimulationin the anterior cingulate cortex and parietal operculum/posterior insula : an event-related functional magnetic resonance imaging study (2000)
  • Author(s): Sawamoto, N. et al.
  • Journal Title: J Neurosci 20 Pages: 7438-7445
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Electrophysiological studies of myoclonus (2000)
  • Author(s): Shibasaki, H.
  • Journal Title: Muscle Nerve 23 Pages: 321-335
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Desynchronization and synchronization of central 20-Hz rhythms associated with voluntary muscle relaxation : a magnetoencephalographic study (2000)
  • Author(s): Toma, K. et al.
  • Journal Title: Exp Brain Res 134 Pages: 417-425
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Human presupplementary motor area is active before voluntary movement : subdural recording of Bereitschaftspotential from medialfrontal cortex (2000)
  • Author(s): Yazawa, S. et al.
  • Journal Title: Exp Brain Res 131 Pages: 165-177
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cortical potentials associated with voluntary mandibular movements (2000)
  • Author(s): Yoshida, K. et al.
  • Journal Title: J Dent Res 79 Pages: 1514-1518
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Essential role of the right superior parietal cortex in Japanese kana mirror reading : An fMRI study (2000)
  • Author(s): Dong, Y., Fukuyama, H., Honda, M., Okada, T., Hanakawa, T., Nakamura, K., Nagahama, Y., Nagamine, T., Konishi, J., Shibasaki, H.
  • Journal Title: Brain 123 ( Pt 4) Pages: 790-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Carotid brainstem reflex myoclonus after hypoxic brain damage (2000)
  • Author(s): Hanakawa, T., Hashimoto, S., Iga, K., Segawa, Y., Shibasaki, H.
  • Journal Title: J Neurol Neurosurg Psychiatry 69 (5) Pages: 672-4
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of primary sensorimotor cortices in generating inhibitory motor response in humans (2000)
  • Author(s): Ikeda, A., Ohara, S., Matsumoto, R., Kunieda, T., Nagamine, T., Miyamoto, S., Kohara, N., Taki, W., Hashimoto, N., Shibasaki, H.
  • Journal Title: Brain 123 ( Pt 8) Pages: 1710-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Autosomal dominant temporal lobe epilepsy in a Japanese family (2000)
  • Author(s): Ikeda, A., Kunieda, T., Miyamoto, S., Fukuyama, H., Shibasaki., H.
  • Journal Title: Neurol Sci 176 (2) Pages: 162-5
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Activity-dependent conduction block in multifocal motor neuropathy (2000)
  • Author(s): Kaji, R., Bostock, H., Kohara, N., Murase, N., Kimura, J., Shibasaki, H.
  • Journal Title: Brain 123 ( Pt 8) Pages: 1602-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Primary somatosensory cortex is actively involved in pain processing in human (2000)
  • Author(s): Kanda, M., Nagamine, T., Ikeda, A., Ohara, S., Kunieda, T., Fujiwara, N., Yazawa, S., Sawamoto, N., Matsumoto, R., Taki.W., Shibasaki, H.
  • Journal Title: Brain Res 853 (2) Pages: 282-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Glucose metabolism in the rat frontal cortex recovered without the recovery of choline acetyltransferase activity after lesioning of the nucleus basalis magnocellularis (2000)
  • Author(s): Katsumi, Y., Hayashi, T., Oyanagi, C., Nagahama, Y., Yamauchi, H., Ono, S., Fukuyama, H., Shibasaki, H.
  • Journal Title: Neurosci Lett 230 (1) Pages: 9-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Different activation of presupplementary motor area, supplementary motor area proper, and primary sensorimotor area, depending on the movement repetition rate in humans (2000)
  • Author(s): Kunieda, T., Ikeda, A., Ohara, S., Yazawa., S., Nagamine, T., Taki, W., Hashimoto, N., Shibasaki, H.
  • Journal Title: Exp Brain Res 135 (2) Pages: 163-72
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Use of cavernous sinus EEG in the detection of seizure onset and spread in mesial temporal lobe epilepsy (2000)
  • Author(s): Kunieda, T., Ikeda, A., Mikuni, N., Ohara, S., Sadato, A., Taki, W., Hashimoto, N., Shibasaki, H.
  • Journal Title: Epilepsia 41. (11) Pages: 1411-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Vascular cell components of the medullary arteries in Binswanger's disease brains : a morphometric and immunoelectron microscopic study (2000)
  • Author(s): Lin, J.X., Tomimoto, H., Akiguchi, I., Matsuo, A., Wakita, H., Shibasaki, H., Budka, H.
  • Journal Title: Stroke 31 (8) Pages: 1838-42
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nonconvulsive focal inhibitory seizure : subdural recording from motor cortex (2000)
  • Author(s): Matsumoto, R., Ikeda., A., Ohara, S., Kunieda, T., Kimura, K., Takahashi, J.B., Miyamoto, S., Taki, W., Hashimoto, N., Shibasaki, H.
  • Journal Title: Neurology 55 (3) Pages: 429-31
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nicotine-sensitive writer's cramp (2000)
  • Author(s): Murase, N., Kaji, R., Sakamoto, T., Shimazu, H., Matumoto, S., Kohar, N., Shibasaki, H., Kimura, J.
  • Journal Title: Mov Disord 15 (6) Pages: 1276-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Abnormal premovement gating of somatosensory input in writer's cramp (2000)
  • Author(s): Murase, N., Kaji, R., Shimazu, H., Katayama-Hirota, M., Ikeda, A., Kohara, N., Kimura, J., Shibasaki, H., Rothwell, J.C.
  • Journal Title: Brain 123 ( Pt 9) Pages: 1813-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Attentional modulation of parieto-occipital cortical responses : implications for hemispatial neglect (2000)
  • Author(s): Nakamura, K., Honda, M., Okada, T., Hankawa, T., Fukuyama, H., Konishi, J., Shibasaki, H.
  • Journal Title: J Neurol Sci 1.76 (2) Pages: 136-43
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Implication of sensorimotor integration in the generation of periodic dystonic myoclonus in subacute sclerosing panencephalitis (SSPE) (2000)
  • Author(s): Oga, T., Ikeda, A., Nagamine, T., Sumi, E., Matsumoto, R., Akiguchi, l., Kimura, J., Shibasaki, H.
  • Journal Title: Mov Disord 15 (6) Pages: 1173-83
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Electrocorticogram-electromyogram coherence during isometric contraction of hand muscle in human (2000)
  • Author(s): Ohara, S., Nagamine.T., Ikeda, A., Kunieda, T..Matsumoto, R., Taki, W., Hashimoto.N., Baba, K., Mihara., T., Salenius, S., Shibasaki, H.
  • Journal Title: Clin Neurophysiol 111 (11) Pages: 2014-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Movement-related change of electrocorticographic activity in human supplementary motor area proper (2000)
  • Author(s): Ohara, S., Ikeda, A., Kunieda, T., Yazawa, S., Baba, K., Nagamine, T., Taki, W., Hashimoto, N., Mihara, T., Shibasaki, H.
  • Journal Title: Brain 123 ( Pt 6) Pages: 1203-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expectation of pain enhances responses to nonpainful somatosensory stimulation in the anterior cingulate cortex and parietal operculum/posterior insula : an event-related functional magnetic resonance imaging study (2000)
  • Author(s): Sawamoto, N., Honda, M., Okada, T., Hanakawa, T., Kanda, M., Fukuyama, H., Konishi, J., Shibasaki, H.
  • Journal Title: J Neurosci 20(19) Pages: 7438-45
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Electrophysiological studies of myoclonus (2000)
  • Author(s): Shibasaki, H.
  • Journal Title: Muscle Nerve 23 (3) Pages: 321-35
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Desynchronization. and synchronization of central 20-Hz rhythms associated with voluntary muscle relaxation: a magnetoencephalographic study (2000)
  • Author(s): Toma, K., Nagamine, T., -Yazawa, S., Terada., K., Ikeda, A., Honda, M., Oga, T., Shibasaki, H.
  • Journal Title: Exp Brain Res 134(4) Pages: 417-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human presupplementary motor area. Is active before voluntary movement : subdural recording of Bereitschaftspotential from medial frontal cortex (2000)
  • Author(s): Yazawa, S., Ikeda, A., Kunieda, T., Ohara, S., Mima, T., Nagamine, T., Taki, W., Kimura, J., Hori, T., Shibasaki, H.
  • Journal Title: Exp Brain Res 131(2) Pages: 165-77
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cortical potentials associated with voluntary mandibular movements (2000)
  • Author(s): Yoshida, K., Kali, R., Hamano, T., Kohara, N., Kimura., J., Shibasaki, H., Ilzuka, T.
  • Journal Title: J Dent Res 79(7) Pages: 1514-8
  • Description: 「研究成果報告書概要(欧文)」より