2004 Fiscal Year Final Research Report Summary
Mechanism of transcriptional regulation by nuclear receptors
| Project/Area Number |
12219206
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATO Shigeaki The University of Tokyo, Institute of Molecular and Cellular Biosciences, Professor, 分子細胞生物学研究所, 教授 (60204468)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEYAMA Ken-ichi The University of Tokyo, Institute of Molecular and Cellular Biosciences, Assistant Professor, 分子細胞生物学研究所, 助手 (30323570)
TAKADA Ichiro The University of Tokyo, Institute of Molecular and Cellular Biosciences, Assistant Professor, 分子細胞生物学研究所, 助手 (50361655)
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| Project Period (FY) |
2000 – 2004
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| Keywords | transcription / co-regulator / sex hormone / nuclear receptor / RNA splicing |
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| Research Abstract |
The most of prostate and breast cancers are dependent on the actions of sex steroid hormones in tumorigenesis. The actions of sex steroid hormones are believed to be mediated through transcriptional regulations by their nuclear receptors. For hormone-dependent regulations by nuclear receptors, a number of different nuclear complexes have been identified, that include chromatin remodeling and histone modifying complexes. To understand the hormone-induced development of such reproductive organ cancers, we have tried to identify several complexes supporting the sex steroid hormone receptors. One of the receptor-interacting complexes has turned out a spliceosome complex, and this complex physically and functionally associate with the human estrogen receptor a. As this interaction was depending on the phospholiation of the ER by MAP kinase, we propose that cross-talk of estrogen and growth factor signalings in breast cancer development mediates RNA splicing control.
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Research Products
(12 results)
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[Journal Article] Splicing potentiation by growth factor signals via estrogen receptor phosphorylation.2005
Author(s)
Masuhiro, Y., Mezaki, Y., Sakari, M., Takeyama, K., Yoshida, T., Inoue, K., Yanagisawa, J., Hanazawa, S., O'Malley, B.W., Kato, S.
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Journal Title
Proc. Natl. Acad. Sci. USA (in press)
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Brain masculinisation requires androgen receptor function.2004
Author(s)
Sato, T., Matsumoto, T., Kawano, H., Watanabe, T., Uematsu, Y., Sekine, K., Fukuda, T., Aihara, K., Krust, A., Yamada, T., Nakamichi, Y., Yamamoto, Y., Nakamura, T., Yoshimura, K., Yoshizawa, T., Metzger, D., Chambon, P., Kato, S.
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Journal Title
Proc. Natl. Acad. Sci. USA 101
Pages: 1673-1678
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Wnt/β-catenin and estrogen signaling converge in vivo.2004
Author(s)
Kouzmenko, A.P., Takeyama, K., Ito, S., Furutani, T., Sawatsubashi, S., Maki, A., Suzuki, E., Kawasaki, Y., Akiyama, T., Tabata, T., Kato, S.
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Journal Title
J. Biol. Chem. 279
Pages: 40255-40258
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Juvenile hormones antagonize ecdysone actions through co-repressor recruitment to EcR/USP heterodimers.2004
Author(s)
Maki, A., Sawatsubashi, S., Ito, S., Shirode, Y., Suzuki, E., Zhao, Y., Yamagata, K., Kouzmenko, A., Takeyama, K.Kato, S.
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Journal Title
Biochem. Biophys. Res. Commun. 320
Pages: 262-267
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP2202004
Author(s)
Wada, 0., Oishi, H., Takada, I., Yanagisawa, J., Yano, T., Kato, S.
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Journal Title
Oncogene 23
Pages: 6000-6005
Description
「研究成果報告書概要(欧文)」より
