| Co-Investigator(Kenkyū-buntansha) |
FUJIOKA Tomoaki Urology, Iwate University School of Medicine, Professor, 医学部, 教授 (80173409)
TSUKAMOTO Taiji Urology, Sapporo Medical University, Professor, 医学部, 教授 (50112454)
MIKI Tuneharu Urology, Kyoto prefectural University of Medicine, Professor, 医学部, 教授 (10243239)
UOSAKA Masahiko Yokohama City University School of Medicine, Professor, 医学部, 教授 (30106330)
AKAZA Hideyuki Urology, University of Tsukuba School of Medicine, Professor, 医学専門群, 教授 (70010486)
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| Research Abstract |
there are a many common disease in the genitourinary tract organ. For example, urinary tract calculi (uric acid or, oxalic acid calcium calculi), BHP, the anormalies in infant urinary tract and in male sex organs, the genitourinary tract cancer, and male sterility are such kinds of disease. It is difficult to explain such kinds of diseases as single gene diseases such as recessive or dominant hereditary diseases. These are regarded as multifactor diseases. The causative genes in these diseases are not known yet. It is important for us to accumulate DNA from the organs or blood DNA in such patients. It is also essential to analyze single nucleotide polymorphism (SNP) of candidate gene from accumulated DNA. In the present study we selected some among such kinds of common disease and accumulated DNAs from such patients. We tried to collect the 300 DNAs from the diseases such as BPH, urine tract calculi, genitourinary tract cancer (prostatic cancer, urothelial cancer, kidney cancer, germ cell tumor), We also performed DNA microarray analyses with some study designs for such diseases in order to select candidate gene groups. If causative genes are detected and new idea for the treatment is elucidated in urinary tract calculi, BPH, urinary tract anormalv in infancy and male sex organs, the genitourinary tract cancer, future foundations for the urology are established and further advances for clinical diagnosis and treatment become possible.
Blood DNAs are collected in patients with 150 of kidney cancers, 46 of germ cell tumnrs 273 of prostatic cancers, 276 of tumors in the urinary bladder, 141 of PBH, 129 of urine tract calculi, 28 of hypospadia, 9 of VUR, other 56 diseases, and 37 of normality person. Total number reachs to 1145 in this project. We were able to search some candidate genes in DNA microarray analyses in some study designs. Each members also performed a study with their own study project and got some result.
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