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2002 Fiscal Year Final Research Report Summary

Drug Delivery based on Multiplicity of Various Membrane Transporters

Research Project

Project/Area Number 12307057
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 応用薬理学・医療系薬学
Research InstitutionKanazawa University

Principal Investigator

TSUJI Akira  Kanazawa University, Pharmaceutical Sciences, Professor, 薬学部, 教授 (10019664)

Co-Investigator(Kenkyū-buntansha) SAI Yoshimichi  Kanazawa University, Graduate School, Assistant Professor, 大学院・自然科学研究科, 助手 (40262589)
TAMAI Ikumi  Tokyo University of Science, Pharmaceutical Sciences, Professor, 薬学部, 教授 (20155237)
Project Period (FY) 2000 – 2002
Keywordstransporter / absorption / drug disposition / systemic carintine deficiency / quantitative PCR / adenovirus vector / drug delivery / single nucleotide polymorphism
Research Abstract

The author' s research on transporter-mediated pharmacokinetics focuses on the molecular functional characteristics of drug transporters including oligopeptide transporter, monocarboxylic acid transporter, anion transporter, organic cation transporters, organic cation/carnitine transporters (OCTNs) and the ATP-binding cassette transporters P-glycoprotein and MRP2. We have successfully demonstrated that the transporters play important roles in the influxes and/or effluxes of drugs in intestinal and renal epithelial cells, hepatocytes and brain capillary endothelial cells that form the blood-brain barrier. In the systemic carnitine deficiency (SCD) phenotype mouse model, juvenile visceral seatosis (jvs) mouse, a mutation in the OCTN2 gene was found. Furthermore, several types of mutation in human SCD patients were found, demonstrating that OCTN2 is a physiologically important carnitine transporter. OCTNs transport not only carnitine but also various organic cationic drugs in a sodium-independent manner. It is suggested that OCTNs are multifunctional transporters for the uptake of carnitine into tissue cells and at the same time for the elimination of intracellular organic cationic drugs. In this research term, novel cDNA of organic anion transporters i.e., OATP-B, OATP-D and OATP-E have been isolated and functionally characterized. Furthermore, single nucleotide polymorphism of OATP-B, OATP-C and OCTN2 in the Japanese population was analyzed. Although more data should be collected, such information will enable us to establish ultimate drug delivery system.

  • Research Products

    (87 results)

All Other

All Publications (87 results)

  • [Publications] Uchino, H.: "p-Aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1"Biochem. Biophys. Res. Commun.. 270・1. 254-259 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchino, H.: "Faropenem transport across the renal epithelial luminal membrane via inorganic phosphate transporter Npt1"Antimicrob. Agents Chemother.. 44・3. 574-577 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamai, I.: "Molecular and functional characterization of organic cation/carnitine transporter family in mice"J. Biol. Chem.. 275・51. 40064-40072 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mayatepek, E.: "Two novel missense mutations of the OCTN2 gene (W283R and V446F) in a patient with primary systemic carnitine deficiency"Hum. Mutat.. 15・1. 118 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamai, I.: "Anion antiport mechanism is involved in transport of lactic acid across intestinal epithelial brush-border membrane"Biochim. Biophys. Acta. 1468・1-2. 285-292 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ogihara, T.: "In situ in vitro evidence for stereoselective and carrier-mediated transport of monocarboxylic acids across intestinal epithelial tissue"Biol. Pharm. Bull.. 23・7. 855-859 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ogihara, T.: "Structural requirement of substrates for stereoselective monocarboxylate tranaport in Caco-2 cells"Pharm. Pharmacol. Commun.. 6. 161-165 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamai, I.: "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family"Biochem. Biophys. Res. Commun.. 273・1. 251-260 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kido, Y.: "Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies"Pharm. Res.. 17・1. 55-62 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamai, I.: "Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier"J. Pharmacol. Exp. Ther.. 295・1. 146-152 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamai, I.: "Transporter-mediated permeation of drugs across the blood-brain barrier"J. Pharm. Sci.. 89. 1371-1388 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakanishi, T.: "Cancer cell-targeted drug delivery utilizing oligopeptide transport activity"Int. J. Cancer. 88・2. 274-280 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirohashi, T.: "Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2)"J. Pharmacol. Exp. Ther.. 292・1. 265-270 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamai, I.: "Transporter-mediated permeation of drugs across the blood-brain barrier"J. Pharm. Sci.. 89. 1371-1388 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 辻 彰: "薬物の生体膜輸送機構解析を基盤とした体内動態制御に関する研究"薬物動態. 15. 112-135 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 辻 彰: "消化管吸収過程における薬物間相互作用"月刊薬事. 42. 287-293 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 辻 彰: "トランスポーターを介した血液脳関門薬物透過に関する研究"Pharm. D.. 1-5 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 辻 彰: "薬物の血液脳関門透過性の改善"臨床薬理の進歩. 12-20 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玉井郁巳: "小腸上皮トランスポーター群の分子機構論的解析と薬物の経口デリバリーへの応用"薬学研究の進歩. 16. 77-88 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玉井郁巳: "トランスポーターが関与する薬物動態と病態"薬事新報. 2141. 9-15 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玉井郁巳: "OCTNトランスポーターファミリーの組織分布・輸送の多様性"薬物動態. 15. 182-188 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamai, I: "Functional characterization of human organic anion transporting polypeptide OATP-B in comparison with liver-specific OATP-C"Pharm. Res.. 18・9. 1262-1269 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Naruhashi, K: "Secretory-transport of p-aminohippuric acid across intestinal epithelial cells in Caco-2 cells and isolated intestinal tissue"J. Pharm. Pharmcol.. 53・1. 73-81 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kido Y: "Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier"J. Neurochem.. 79・5. 959-969 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamai, I.: "Na+-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney"Biochim. Biophys. Acta. 1512・2. 273-284 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Higashi, Y: "Effect of gamma-butyrobetaine of fatty liver in juvenile visceral steatosisin mice"J. Pharm. Pharmcol.. 53・4. 527-533 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohashi, R: "Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2"Mol. Pharmacol.. 59・2. 358-366 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamai, I.: "Blood-brain barrier transport of H1-antagonist ebastine and its metabolite carebastine"J. Drug Targeting. 8・6. 383-393 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishikawa, F.: "Improved nasal bioavailability of elcatonin by insoluble power formulation"Int. J. Pharm.. 224・1-2. 105-114 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 木戸康人: "血液脳関門の排出系"生体の科学. 52・6. 571-576 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 崔 吉道: "トランスポーターを介した薬物相互作用"医学の歩み. 197・2. 23-31 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玉井 郁巳: "血液脳関門と神経疾患治療薬"CLINICAL NEUROSCIENCE. 19・2. 21-23 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玉井 郁巳: "トランスポーター遺伝子多型"月刊薬事. 42・3. 53-58 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 辻 彰: "生体膜輸送の分子機構に関する生物薬剤学的研究"薬学雑誌. 122(12). 1037-1058 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsuji, A.: "Transporter-mediated drug interactions"Drug Metabol. Pharmacokin.. 17(4). 253-274 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toyobuku, H.: "Enhanced Delivery of Drugs to the Liver by Adenovirus-Mediated Heterologous Expression of the Human Oligopeptide Transporter PEPT1"J. Pharmacol. Exp. Ther.. 301(3). 812-819 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yui, N.: "Inhibitory Effect of Supramolecular Polyrotaxane-Dipeptide Conjugates on Digested Peptide Uptake via Intestinal Human Peptide Transporter"Bioconjug Chem.. 13(3). 582-587 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohashi, R.: "Studies on Functional Sites of Organic Cation/Carnitine Transporter OCTN2 (SLC22A5) Using a Ser467Cys Mutant Protein"J. Pharmacol. Exp. Ther.. 302(3). 1286-1294 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nozawa, T.: "Genetic polymorphisms of human organic transporters OATP-C (SLC21A6) and OATP-B (SLC21A9) : Allele frequencies in the Japanese population and functional analysis"Drug Metabol. Pharmacokin.. 17(3). 237-244 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Naruhashi, K.: "PepT1 mRNA expression is induced by starvation and its level correlates with absorptive transport of cefadroxil longitudinally in the rat intestine"Pharm. Res.. 19(10). 1415-1421 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kido, Y.: "Evalution of blood-brain barrier transporters by co-culture of brain capillary endothelial cells with astrocytes"Drug Metabol. Pharmacokin.. 17(1). 34-41 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玉井郁巳: "新・ドラックデリバリーシステム"トランスポーターとドラッグデリバリーシステム""シーエムシー. 13 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchino, H., Tamai, I., Yamashita, K., Minemoto, Y., Sai, Y., Yabuuchi, H., Miyamoto, K., Takeda, E. and Tsuji, A.: "p-Aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1."Biochem. Biophys. Res. Common.. 270(1). 254-259 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uchino, H., Tamai, I., Yabuuchi, H., China, K., Miyamoto, K., Takeda, E., and Tsuji, A.: "Faropenem transport across the renal epithelial luminal membrane via inorganic phosphate transporter Npt1."Antimicrob. Agents Chemother.. 44(3). 574-577 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamai, I., Ohashi, R., Nezu, J., Sai, Y., Kobayashi, D., Oku, A., Shimane, M. and Tsuji, A.: "Molecular and functional characterization of organic cation/carnitine transporter family in mice."J. Biol. Chem.. 275(51). 40064-40072 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mayatepek, E., Nezu, J., Tanai, I., Oku, A., Katsura, M., Shimane, M. and Tsuji, A.: "Tow novel missence mutations of the OCTN2 gene (W283R and V446F) in a patient with primary systemic carnitine deficiency."Human Mutation (Online). 15(1). 118 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamai, I., Ogiwara, T, Takanaga, H., Maeda, H. and Tsuji, A.: "Anion antiport mechanism is involved in transport of lactic acid across intestinal epithelial brush-border membrane."Biochim. Biophys. Acta.. 1468(1-2). 285-292 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogihara, T, Tamai, I. and Tsuji, A.: "In situ and in vitro evidence for streoselective and carrier-mediated transport of monocarboxylic across intestinal epithelial tissue."Biol. Pharm. Bull.. 23(7). 855-859 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogihara, T., Tamai, I. and Tsuji, A.: "Structural requirements of substrates for stereoselective monocarboxylate transsport in Caco-2 cells."Pharm. Phrmacol. Commun.. 6(4). 161-165 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamai, I., Nezu, J., Uchino, H., Sai, Y., Oku, A., Shimane, M. and Tsuji, A.: "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family."Biochem. Biophys. Res. Commun.. 273(1). 251-260 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kido, Y., Tamai, I., Okamoto, M., Suzuki, F. and Tsuji, A.: "Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier of rats using in vitro cultured cells and in vivo BUI studies."Pharm. Res.. 17. 55-62 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamai, I., Yamashita, J., Kido, Y., Ohnari, A., Sai, Y., Shima, Y., Naruhashi, K., Koizumi, S. and Tsuji, A.: "Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier."J. Pharmacol. Exp. Ther.. 295(1). 146-152 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamai, I. And Tsuji, A.: "Transporter-mediated Permeation of Drug Across the Blood-Brain barrier."J. Pharm. Sci.. 89,11. 1371-1388 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakanishi, T., Tamai, I., Takaki, A., and Tsuji, A.: "Cancer cell-targeted drug delivery utilizing peptide transporter."Int. J. Cancer. 88(2). 274-280 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirohashi, T., Suzuki, H., Chu, X. Y., Tamai, L, Tsuji, A. and Sugiyama, Y.: "The function and expression of multidrug resistance-associated protein (MRP) family in human colon adenocarcinoma cells (Caco-2)."J. Pharmacol. Exp. Ther.. 292(1). 265-270 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamai, I., Kido, Y., Yamashita, J., Sai, Y. and Tsuji, A.: "Blood-brain barrier transport of H_1-antagonist ebastine and its metabolite carebastine."J. Drug Targeting. 8(6). 383-393 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuji, A.: "Study on regulation of pharmacokinetics of drugs based on the membrane transport mechanisms. (in Japanese)"Xenobio. Metabol. Dispos.. 15. 112-135 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuji, A.: "Drug interaction on intestinal absorption. (in Japanese)"The Pharmaceutical Monthly.. 42(4). 287-293 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuji, A.: "Improvement of blood-brain barrier permeability. (in Japanese)"Pharm. D.. 2. 1-5 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuji, A., Tamai, I., Sai, Y.: "Transporter-mediated blood-brain barrier permeation of drugs. (in Japanese)"Rinsyo-yakuri-no-sinpo. 12-20 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamai, I.: "Drug disposition and diseases related to transporters. (in Japanese)"Yakuji-shinpou.. 2141. 9-15 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamai, I., Ohashi, R., Nezu, J., Oku, A., Shimane, M., Sai, Y., Tsuji, A.: "Molecular and functional characterization of carnitine/organic cation transporter OCTN family in human and mouse. (in Japanese)"Xenobio. Metabol. Dispos.. 15. 182-188 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sai, Y., Tamai, I., Tsuji, A.: "Organic cation/carnitine transporter, A major factor on systemic carnitine deficiency syndrome. (in Japanese)"Kagaku-to-Seibutsu.. 38(7). 432-438 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamai, I., Nozawa, T., Koshida, M., Nezu, J., Sai, Y. and Tsuji, A.: "Functional characterization of human organic anion transporting polypeptide OATP-B in comparison with liver-specific OATP-C."Pharm. Res.. 18(9). 1262-1269 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Naruhashi, K., Tamai, I., Sai, Y,, Suzuki, N. and Tsuji, A.: "Secretory-transport of p-aminohippuric acid across intestinal epithelial cells in Caco-2 cells and isolated intestinal tissue."J. Pharm. Pharmcol.. 53(1). 73-81 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kido, Y.,Tamai, I., Ohnari, A., Sai, Y., Kagami, T., Nezu, J., Nikaido, H., Hashimoto, N., Asano, M. and Tsuji, A.: "Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier."J. Neurochem.. 79(5). 959-969 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamai, I., China, K., Sai, Y., Kobayashi, D., Nezu, J., Kawahara, E. and Tsuji, A.: "Na^+-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney."Biochim. Biophys. Acta.. 1512(2). 273-284 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Higashi, Y., Yokogawa, K., Takeuchi, N., Tamai, I., Nomura, M., Hashimoto, N., Hayakawa, J., Miyamoto, K. and Tsuji, A.: "Effect of gamma-butyrobetaine on fatty liver in juvenile visceral steatosisin mice."J. Pharm. Pharmcol.. 53(4). 527-533 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohashi, R., Tamai, I., Nezu, J., Nikaido, H., Hashimoto, N., Oku, A., Sai, Y., Shimane, M. and Tsuji, A.: "Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2."Mol. Pharmacol.. 59(2). 358-366 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kido, Y., Tamai, I., Uchino, H., Sai, Y., Suzuki, F. and Tsuji, A.: "Molecular and functional identification of large neutral amino acid transporter LAT1 and LAT2 and their pharmacological relevance at the blood-brain barrier."J. Pharm. Pharmcol.. 53(4). 497-503 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishikawa, F., Katsura, M., Tamai, I. and Tsuji, A.: "Improved nasal bioavailability of elcatonin by insoluble power formulation."Int. J. Pharm.. 224(1-2). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Naruhashi, K., Tamai, I., Inoue, N., Muraoka, H., Sai, Y., Suzuki, N. and Tsuji, A.: "Active intestinal secretion of new quinolone antimicrobials and the partial contribution of P-glycoprotein."J. Pharm. Pharmcol.. 53(5). 699-709 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Naruhashi, K., Tamai, I., Inoue, N., Muraoka, H., Sai, Y., Suzuki, N. and Tsuji, A.: "Involvement of multidrug resistance-associated protein 2 in intestinal secretion of grepafloxacin in rats."Antimicrob. Agents Chemother.. 46(2). 344-349 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kido, Y., Sai, Y., Tamai, I., Tsuji, A.: "Efflux transport system at the blood-brain barrier. (in Japanese)"Seitai-no-kagaku.. 52. 571-576 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sai, Y., Tsuji, A.: "Membrane transporter as a site of drug interaction. (in Japanese)"Igaku-no-ayumi.. 197(2). 23-31 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamai, I., Tsuji, A.: "Blood-brain barrier and neuropharmaceuticals. (in Japanese)"CLINICAL NEUROSCIENCE. 19(2). 21-23 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamai, I., Tsuji, A.: "Genetic polymorphisms in transporter. (in Japanese)"The Pharmaceuticals Monthly.. 42(3). 53-58 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuji, A.: "Biopharmaceutical studies on molecular mechanisms of membrane transport. (in Japanese)"YAKUGAKU ZASSHI.. 122(12). 1037-1058 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuji, A.: "Transporter-mediated drug interactions."Drug. Metabol. Pharmacokin.. 17(4). 253-274 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kido, Y., Tamai, I., Nakanishi, T., Kagami, T., Hirosawa, I., Sai, Y. and Tsuji, A.: "Evalution of blood-brain barrier transportsers by co-culture of brain capillary endothelial cells with astrocytes."Drug Metabol. Pharmacokin.. 17(1). 34-41 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toyobuku, H., Sai, Y., Tamai, I. and Tsuji, A.: "Enhanced Delivery of Drugs to the Liver by Adenovirus-Mediated Heterologous Expression of the Human Oligopeptide Transporter PEPT1."J. Pharmacol. Exp. Ther.. 301(3). 812-819 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yui, N., Ooya, T., Kawashima, T., Saito, Y., Tamai, I., Sai, Y. and Tsuji, A.: "Inhibitory Effect of Supramoiecular Polyrotaxane-Dipeptide Conjugates on Digested Peptide Uptake via Intestinal Human Peptide Transporter."Bioconjug Chem.. 13(3). 582-587 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nozawa, T., Nakajima, M., Tamai, I., Noda, K., Nezu, J., Sai, Y., Tsuji, A., and Yokoi, T.: "Genetic Polymorphisms of Human Organic Anion Transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): Allele Frequencies in the Japanese Population and Functional Analysis."J. Pharmacol. Exp. Ther.. 302(2). 804-813 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshikawa, M., Yabuuchi, H., Kuroiwa, A., Ikegami, Y., Sai, Y., Tamai, I., Tsuji, A., Matsuda, Y., Yoshida, H., Ishikawa, T.: "Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4."Gene. 293(1-2). 67-75 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohashi, R., Tamai, I., Inano, A., Katsura, M., Sai, Y., Nezu, J. and Tsuji, A.: "Studies on Functional Sites of Organic Cation/Carnitine Transporter OCTN2 (SLC22A5) Using a Ser467Cys Mutant Protein."J. Pharmacol. Exp. Ther.. 302(3). 1286-1294 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sai, Y., Tsuji, A.: "Analysis of the mechanisms of the drug-drug interaction from a view of pharmacogenomics. (in Japanese)"Nippon Rinsho.. 60(1). 74-80 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toyobuku H., Sai Y., Kagami T., Tamai I., Tsuji A.: "Delivery of Peptide Drugs to the Brain by Adenovirus-mediated heterologous expression of human oligopeptide transporter at the blood-brain barrier."J. Pharmacol. Exp. Ther.. 305(1). 40-47 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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