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2003 Fiscal Year Final Research Report Summary

Study on the usefulness of Hyperbaric Oxygen Therapy for healing promotion in the soft Eissue injuries

Research Project

Project/Area Number 12480003
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 体育学
Research InstitutionUniversity of Tsukuba

Principal Investigator

MIYANAGA Yutaka  University of Tsukuba, Institute of Health & Sports Science, Professor, 体育科学系, 教授 (90010371)

Co-Investigator(Kenkyū-buntansha) MUKAI Naoki  University of Tsukuba, Institute of Health & spouts Science, Lecturer, 体育科学系, 講師 (70292539)
SHIRAKI Hitoshi  University of Tsukuba, Institute of Health & spouts Science, Associate professor, 体育科学系, 助教授 (90206285)
Project Period (FY) 2000 – 2003
Keywordshyperbaric Oxygen / soft tissue injury / healing promotion / wound healing / collagen metabolism / conditioning / lactate acid / free radicals
Research Abstract

Usefulness of Hyperbaric Oxygen (HBO)Therapy has been studied to promote the healing process of the soft tissue injuries commonly seen among athletes. Following results were obtained
1.Repair of experimentally induced muscle rupture : HBO proved to promote the recovery of complete arrangement of muscle fibers and activate the metabolism of hydraxyproline. These findings suggest that collagen metabolism may be activated by HBO
2.Repair of experimentally induced ligament rupture : HBO accelerated wound healing and increased significantly number of the fibroblasts histologically. On the molecular base, pro-α1(I)mRNA increased significantly at 7 to 14 days after rupture. These results may be considered to work well for collagen metabolism
3.Repair of experimentally induced ligament rupture by difference of setting conditions : As for the wound healing and increase of the fibroblasts, HBO worked better and then higher ATA, longer duration of incubation was much effective
4.Clinical usefulness f … More or injuries and reconditioning in athletes : Twenty-two athletes with soft tissue injuries were exposed to HBO at 1.3〜2 ATA, for 30〜90 min., 3.6 times on the average. Seventeen cases showed satisfactory recovery and good response to HBO was shown in the cases of early period after injuries. Five cases had minor earache without the effect on performance after application. Olympic athletes among Nagano Winter Olympic game were exposed to HBO at 1.3 ATA, for 30〜40 min. for reconditioning and removal of muscle soreness. All seven athletes Here satisfied quite with HBO and resulted in good performance without complications
5.Removal of lactate acid : Su male students after maximal exercise using bicycle were studied under 1.3 ATA or 2 ATA and removal rate of lactic acid was higher than under normal atmosphere, much effective at 1.3 ATA
6.Evaluation of safety : Positive feeling as "feel comfortable", "fall into sleep" was obtained from most of the thirty,students under HBO. As for side effects, earache and headache were noticed in several cases, but these could be controlled by changing the pace up of pressure. Free radicals remained normal both before and after incubation by free radicals analysis system
7.Others : HBO will be able to have effect over training and this is under study
In conclusion, HBO Therapy (under 2 ATA) has proved to be effective for the wound healing of the soft tissue injuries Less

  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] 石井良昌 他: "高気圧酸素寮法の最大運動後の乳酸濃度に及ぼす影響"日本高気圧環境医学会雑誌. 30(2). 109-114 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石井良昌 他: "スポーツ選手の軟部組織傷害に対する高気圧酸素療法の治療経験たついて"日本整形外科スポーツ医学会雑誌. 17(1). 7-14 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishii Yosimasa, et al.: "Metabolic Effects of Hyperbaric Oxygen on Muscle Tear in the Hind Limb of Rats"Advances in Exercise and Sports Physiology. 4(1). 11-16 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮永 豊 他: "血液に送り込んだ酸素が筋・腱のダメージと疲労を回復させる"Coaching Clinic. 8. 6-10 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石井良昌 他: "スポーツ競技早期復帰に対する高気圧酸素の有用性"骨・関節・靱帯. 12(6). 785-789 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] YOSHIMASA ISHII, et al.: "Effects of Hyperbaric oxygen on procollagen Messenger RNA Levels and Collagen Synthesis in the Healing of Rat Tendon Laceration"Tissue engineering. 5(3). 279-286 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshimasa Ishii, et al.: "Dynamic viscoelasticity of the healing ligament treated by in vivo intermittent oxygen exposure in rats"Materials Science and Engineering C. 17. 71-73 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshimasa Isii, et al.: "Effects of different exposures of hyperbaric oxygen on ligament healing in rats"Journal of Orthopeadic Research. 20. 353-356 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] TAISUKE KINUGASA, et al.: "Statistical evaluation of Conditioning for an Elite Collegiate Tennis Player Using a Single-Case Design"Journal of Strength and Conditioning Research. 16(3). 466-471 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石井良昌 他: "スポーツ選手に対する高気圧酸素療法の応用-1 意義と理論的背景"Training Journal. 275. 63-65 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石井良昌 他: "スポーツ選手に対する高気圧酸素療法の応用-2 基礎研究"Training Journal. 276. 60-63 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石井良昌 他: "スポーツ選手に対する高気圧酸素療法の応用-3 臨床応用"Training Journal. 277. 80-82 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮永豊: "時代のニーズに応えるスポーツ医学を目指して"日本臨床スポーツ医学会誌. 10(1). 1-4 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshimasa Ishii, et al.: "Effects of transcutaneous topical injection of oxygen on vascular endothelial growth factor gene into the healing ligament in rats"Journal of Orthopaedic Research. 21. 1113-1117 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石井良昌 他: "アスリートに対する高気圧酸素の使用と安全管理"Coaching Clinic. 4. 59-61 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮永豊: "高気圧酸素のスポーツ医学への応用"茨城県スポーツ医科学報告書. 9. 27-28 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishii, Y, Miyanaga, Y.et al.: "The effect of hyperbaric oxygen therapy on the lactate concentration after maximal exercise"Journal of Japanese Society for Hyperbaric Medicine (in Japanese). 30. 109-114 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Isllii, Y, Miyanaga, Y.et al.: "The Experience of Hyperbaric Oxygen Therapy fir Soft Tissue Injuries of Sports Athletes"Japanese Journal of Orthopaedic Sports Medicine (in Japanese). 17. 7-14 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishii, Y, Miyanaga, Y.et al.: "Metabolic Effects of Hyperbolic Oxygen on Muscle Tear in the Hind Limb of Rats"Advances in Exercise and Sports Physiology. 4. 11-16 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyanaga, Y, Ishii, Y.: "The oxygen seal into blood recorders musculotendinous damage and fatigue"Coaching Clinic (in Japanese). 12(8). 6-10 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishii, Y, Miyanaga, Y.et al.: "The role of hyperbaric oxygen for the early retina to sports activities"Bone・Joint・Ligament (in Japanese). 12. 785-789 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishii, Y, Miyanaga, Y.et al.: "Effects of Hyperbaric Oxygen on Procollagen Messenger RNA Levels and Collagen Synthesis in the Healing of Rat Tendon Laceration"Tissue Engineering. 5. 279-286 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishii, Y, Ushicia, T.et al.: "Dynamic viscoelasticity of the healing ligamant treated by in viva intermittent oxygen exposure in rats"Materials science and Engineering C. 17. 71-73 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishii, Y, Ushida, T.et al.: "Effects of different exposure of hyperbaric oxygen on ligament healing in cats"Journal of Orthopaedic Research. 20. 353-356 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kinugasa, T, Miyanaga, Y.et al.: "Statistical Evaluation of Conditioning for an Elite Collegiate Tennis Player Using a single-Case Design"Journal of Strength and Conditioning Research. 16. 466-471 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishii, Y, Shiraki, H.et al.: "The Application of Hyperbaric Oxygen Therapy for athletes. Part-1"Training Journal (in Japanese). 275. 63-65 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishii, Y, Shiraki, H.et al.: "The Application of Hyperbaric Oxygen Therapy for athletes. Part-2"Training Journal (in Japanese). 276. 60-63 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishii, Y, Shiraki, H.et al.: "The Application of Hyperbaric Oxygen Therapy for athletes. Part-3"Training Journal (in Japanese). 277. 80-82 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyanaga, Y: "Sports medicine meet the needs of the times"Japanese Journal of Clinical Sports Medicine (in Japanese). 10. 1-4 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishii, Y, Ushida, T.et al.: "Effects of transcutaneous topical injection of oxygen on vasular endotherial growth factor gene into the healing ligament in its"Journal of Orthopaedic Research. 21. 1113-1117 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishii, Y, Miyanaga, Y.et al.: "The use and safety management of the hyperbaric oxygen for athletes"Coaching Clinic (in Japanese). 18(4). 59-61 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyanaga, Y: "Application to the sport medicine of the hyperbaric oxygen"Ibaraki Sport medical Science Report (in Japanese). 9. 27-28 (2004)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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