2001 Fiscal Year Final Research Report Summary
ROLES OF PROSTANOID RECEPTORS COLON CARCINOGESIS
| Project/Area Number |
12670226
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | NATIONAL CANCER CENTER RESEARCH INSTITUTE |
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Principal Investigator |
KAWAMORI Toshihiko NATIONAL CANCER CENTER RESEARCH INSTITURE, CANCER PREVENTION DIVISION, SECTION HEAD, 研究所・がん予防研究部, 室長 (80311413)
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| Co-Investigator(Kenkyū-buntansha) |
WAKABAYASHI Keiji NATIONAL CANCER CENTER RESEARCH INSTITURE, CANCER PREVENTION DIVISION, CHIEF, 研究所・がん予防研究部, 部長 (60158582)
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| Project Period (FY) |
2000 – 2001
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| Keywords | COLON CARCINOGENESIS / PROSTANOIDS / RECEPTOR / KNOCKOUT MICE / ABERRANT CRYPT FOCI / EPI / EP4 |
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| Research Abstract |
There is accumulating evidence that arachidonic acid cascade is closely related with colon cancer development. Prostanoids, arachidonic acid metabolites, exert their biological functions through binding to their membrane receptors. Eight types of prostanoid receptors have been identified (EP1 4 for PGE2, DP for PGD2, FP for PGF2α, IP for PGI2, and TP for TxA2). Roles of prostanoid receptors in colon carcinogenesis were still unknown. Therefore, we investigated if receptor deficient mice reduced aberrant crypt foci (ACF), thought to be preneoplastic lesions, induced by azoxymethane (AOM). Two types of receptor deficient mice (EP1 and EP4) reduced number of ACF as compared with wild type mice (36 ＆ 44% reduction, respectively). Then, we confirmed the results using selective receptor antagonists. We concluded that EP1 and EP4 receptors play pivotal roles in colon carcinogenesis.
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Research Products
(4 results)
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[Publications] Mutoh, M., Watanabe, K., Kitamura, T., Shoji, Y., Takahashi, M., Kawamori, T., Tani, K., Kobayashi, M., Maruyama, T., Kobayashi, K., Ohuchida, S., Sugimoto, Y., Narumiya, S., Sugimura, T., Wakabayashi, K.: "Involvement of prostaglandin E receptor subtype EP4 in colon careinogensis"Cancer Resaerch. 62. 28-32 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Kawamori, T., Uchiya, N., Kitamura, T., Ohuchida, S., Yamamoto, H., Maruyama, T., Sugimura, T, Wakabayashi, K.: "Evalution of a selective prostaglandin E receptor EP1 antagonist for potential properties in colon earcinogenesis"Anticancer Research. 21, (in press)
Description
「研究成果報告書概要(欧文)」より
