2002 Fiscal Year Final Research Report Summary
Possibility of energy restriction as a means of preventing sudden death among the elder
| Project/Area Number |
12670314
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Hyogo College of Medicine (2001-2002)
Akita University (2000) |
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Principal Investigator |
WADA Yasuhiko Hyogo College of Medicine, Dept.of Medicine, Associate Professor, 医学部, 助教授 (10261653)
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| Co-Investigator(Kenkyū-buntansha) |
KOIZUMI Akio Kyoto University Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (50124574)
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| Project Period (FY) |
2000 – 2002
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| Keywords | Energy restriction / Heart / Gene expression / cDNA array / Hypothermia / Daily torpor / 24-hour EGG / Arrhythmia |
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| Research Abstract |
Energy restriction (ER) without malnutrition has been known to retard aging processes and extend the life span in various species of mammals. We investigated the effects of ER on morphological and physiological properties of the heart of C57B1/6 male mice using AKITA diet. We analyzed the expression of heart mRNA from ER (200 kJ/week) or control (400 kJ/week) B6 11-month-old male mice using cDNA array membranes including 588 genes. mRNAs increased by ER were fetal myosin alkali light chain genes and transcriptional factor 1 for heat shock gene (HSF1). Electron microscopy revealed that ER cardiac muscle had very few lipid droplets, which were often found in control one. Heart of ER mice was not hypertrophic compared to control. Ambulatory long-term recording of body temperature and electrocardiogram of aged mice revealed that the heart rate of ER mice changed before body temperature did, and the rate was dramatically decreased to one fifth when body temperature was decreased. When body temperature changed up and down dangerous arrhythmia, such as ventricular premature beat, was not found in ER mice. These findings mean that the heart of ER mice has good adaptation to hypothermia. Moreover, it is suggested that the ER heart has an important role in changing body temperature.
In conclusion, ER may alter structure and functional properties of the heart and make it adaptable to wide range of body temperature and energy availability. This also suggests possibility of ER as a means of preventing lethal arrhythmia, and also sudden deaths, among the elder.
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Research Products
(8 results)
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[Publications] Iso H, Date C, Yamamoto A, Toyoshima H, Tanabe N, Kikuchi S, Kondo T, Watanabe Y, Wada Y, Ishibashi T, Suzuki H, Koizumi A, Inaba Y, Tamakoshi A, Ohno Y.: "Perceived mental stress and mortality from cardiovascular disease among Japanese men and women : the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study)"Circulation. 106. 1229-1236 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Fujita, H., Haseyama, T., Kayo, T., Nozaki, J., Wad,. Y., Ito, S., koizumi,. A.: "Increased expression of glutathione S-transferase in renal proximal tubules in the early stages of diabetes : a study of type-2 diabetes in the Akita mouse model"Exp.Nephrol.. 9. 380-386 (2001)
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「研究成果報告書概要(欧文)」より
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[Publications] Iso H, Date C, Yamamoto A, Toyoshima H, Tanabe N, Kikuchi S, Kondo T, Watanabe Y, Wada Y, Ishibashi T, Suzuki H, Koizumi A, Inaba Y, Tamakoshi A, Ohno Y: "Perceived mental stress and mortality from cardiovascular disease among Japanese men and women : the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study)"Circulation. 106. 1229-1236 (2002)
Description
「研究成果報告書概要(欧文)」より
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