2003 Fiscal Year Final Research Report Summary
Epidemiological research on the etiology of Multiple Risk Factor Syndrome
| Project/Area Number |
12670352
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Nagoya University |
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Principal Investigator |
TAMAKOSHI Koji Nagoya University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 講師 (30262900)
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| Co-Investigator(Kenkyū-buntansha) |
TOYOSHIMA Hideaki Nagoya University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (10023657)
KONDO Takaaki Nagoya University, School of Medicine, Associate Professor, 医学部, 助教授 (00195900)
YATSUYA Hiroshi Nagoya University, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (30324437)
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| Project Period (FY) |
2000 – 2003
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| Keywords | Multiple Risk Factor Syndrome / Metabolic syndrome / insulin resistance / obesity / inflammation / atherosclerosis |
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| Research Abstract |
We conducted the cohort study of about 7,000 male workers in 1997. In this study, we examined the role of obesity most likely lying in the upstream of insulin resistance in the genesis of Multiple risk factor syndrome recently called as Metabolic syndrome (MS). We obtained the new knowledge that obesity probably caused insulin resistance syndrome and that weight variability from adolescence probably caused insulin resistance and MS. Furthermore, we found that t each component of MS (obesity, hypertension, hypertrigriceridemia, hyper-LDL cholesterolemia, hypo-HDL cholesterolemia, hyperinsulinemia, hyperuricemia) was associated with the systemic low-grade inflammation defined as elevated C-reactive protein and that CRP increased as the number of coexisting MS components increased. From these results, we speculated the cascade of events arriving at cardiovascular disease as follows : obesity→insulin resistance→components of MS other than obesity→Atherosclerosis→systemic low-grade inflammation→progression atherosclerosis→cardiovascular event.
In the view of our results, obesity plays an important role in the etiology of MS. In recent years, leptin attracts attention as hormone related to obesity. Our future research is to elucidate the role of hyperleptinemia, leptin resistance in the etiology of MS.
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Research Products
(10 results)
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[Publications] Tamakoshi K, Yatsuya H, Kondo T, Hori Y, Ishikawa M, Zhang H, Murata C, Otsuka R, Zhu S, Toyoshima H.: "The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state."Int J Obes Relat Metab Disord.. 27(4). 443-449 (2003)
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「研究成果報告書概要(欧文)」より
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[Publications] Tamakoshi K, Yatsuya H, Kondo T, Ishikawa M, Zhang H, Murata C, Otsuka R, Mabuchi T, Hori Y, Zhu S, Yoshida T, Toyoshima H.: "Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men."Int J Obes Relat Metab Disord.. 27(9). 1059-1065 (2003)
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「研究成果報告書概要(欧文)」より
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[Publications] Yatsuya H, Tamakoshi K, Hattorni H, Otsuka R, Wada K, Zhang H, Mabuchi T, Ishikawa M, Murata C, Yoshida T, Kondo T, Toyoshima H.: "Serum phospholipid transfer protein mass as a possible protective factor for coronary heart diseases."Circ J.. 68(1). 11-16 (2004)
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「研究成果報告書概要(欧文)」より
