2002 Fiscal Year Final Research Report Summary
Inflammation-Associated Lipid Mediators in Cholestatic Hepatobiliary Diseases and Effect of PAF-AH
| Project/Area Number |
12670456
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | THE UNIVERSITY OF TSUKUBA |
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Principal Investigator |
SHODA Junichi Institute of Clinical Medicine, University of Tsukuba, Assistant Professor, 臨床医学系, 講師 (90241827)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Hiroshi Graduate School of Pharmaceuticak Sciences, University of Tokyo, 薬学部, 助教授 (80206523)
KAWAMOTO Toru Institute of Clinical Medicine, University of Tsukuba, Assistant Professor, 臨床医学系, 講師 (30282354)
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| Project Period (FY) |
2000 – 2002
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| Keywords | bilirubin / obstractive cholestasis / primary hepatolithiasis / hepatobiliary malignancy / biliary secretory mechanism / canalicular membrane transporter / bile acid / oxidative stress |
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| Research Abstract |
The transport of biliary constituents across the canalicular membrane is the rate-limiting step in bile formation. Since long-standing biliary obstruction and complication of cholangitis associated with biliary infection have a large influence upon the hepatic secretory function through inflammation-related oxidative stress on the liver, interest should be focused on the expression levels of canalicular membrane transporter proteins in the cholestatic liver of patients with hepatobiliary diseases. We determined the molecular and immunohistochemical expression of canalicular transporter proteins, for bilirubin conjugate and bile acid,in the liver of patients with hepatolithiasis and in those of the patients with obstructive cholestasis who had undergone preoperative biliary drainage. Furthermore, their expression levels were correlated with the impairment of biliary secretion.
This study concludes that in the liver of hepatobiliary diseases, the altered expression of the canalicular transporters may be associated with the impairment of bile formation and secretion, propably through inflammation-related oxidative stress on the liver.
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Research Products
(8 results)
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[Publications] Shoda, J., Oda, K., Suzuki, H., Sugiyama, Y., Ito., K, Cohen, D.E., Feng, L., Kamiya, Nimura, Y., Miyazaki, H., Kano, M., Matsuzaki, Y., Tanaka, N.: "Metabolic defects of cholesterol, phospholipid, and bile acid in the liver of patients with intrahepatic calculi, and etiological significance"Hepatology. 33. 1194-1205 (2001)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Shoda, J., Kano,M., Oda, K., Kamiya, J., Nimura, Y., Suzuki H., Sugiyama, Y., Miyazaki, H., Todoroki, T., Stengelin, S., Kramer, W., Matsuzaki, Y., Tanaka, N.: "The expression level of the plasma membrane transporters, multidrug resistance-associated protein (MRP) 2, MRP 3 and bile salt export pump, in the cholestatic liver of patients undergoing biliary drainage."Am J Gastroenterol. 96. 3368-3378 (2001)
Description
「研究成果報告書概要(欧文)」より
