2001 Fiscal Year Final Research Report Summary
Transgenic Mouse of Hepatitis C Virus Infection
| Project/Area Number |
12670464
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OHNISHI Shin The University of Tokyo, Department of Gastroenterology, Assistant Professor, 医学部・附属病院, 講師 (00183236)
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| Project Period (FY) |
2000 – 2001
|
| Keywords | Hepatitis C Virus / Transgenic Mouse / Virus Receptor / CD81 |
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| Research Abstract |
Hepatitis C virus (HCV) binds to human CD81 through the E2 glycoprotein. We produced transgenic mice (B6) expressing the human CD81 protein. Those mice lack expression of endogenous mouse CD81.
Those mice were resistant to HCV infection. We thought that expression of human CD81 alone is insufficient to confer susceptibility to HCV infection in the mouse or B6 mice were resistant to HCV infection. We try to make another strain transgenic mouse model. The presence of additional factors for HCV infection may be required.
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Research Products
(4 results)
