2001 Fiscal Year Final Research Report Summary
Investigation of Basal Ganglia Function and Intrinsic Dopamine Release by Positron Emission Tomography
| Project/Area Number |
12670635
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Tokyo Metropolitan Institute of Gerontology |
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Principal Investigator |
ISHII Kenji Tokyo Metropolitan Institute of Gerontology, Positron Medical Center, Research associate, ポジトロン医学研究部門, 研究助手 (10231135)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Yuichi Tokyo Metropolitan Institute of Gerontology, Positron Medical Center, Senior Researcher, ポジトロン医学研究部門, 主任研究員 (60205002)
ISHIWATA Kiichi Tokyo Metropolitan Institute of Gerontology, Positron Medical Center, Senior Researcher, ポジトロン医学研究部門, 主任研究員 (50143037)
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| Project Period (FY) |
2000 – 2001
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| Keywords | PET / dopamine / raclopride / basal ganglia / voluntary movement / learning / human / brain |
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| Research Abstract |
To investigate the role of nigrostriatal dopamine system in performing a skilled complex motor task without leaning such as writing, we measured endogenous dopamine release in human brain with ^<13>C-raclopride (RAC) and PET.
We studied six right-handed healthy volunteers (ages 22.0±1.7 years). After an intravenous injection of RAC, a 60 minites dynamic scan was performed. Each subject participated in RAC-PET twice on the same day (scan interval 145.0±35.2 minutes) under two different conditions ; during hand writing and at rest in balanced order. In the writing condition, the subjects was asked to dictate sentences as quick as possible on a computer-controlled writing pad with pen tool using their right hand. In resting condition, the subject was asked to watch the display without any movement. Endgeneous dopamine release was estimated indirectly based on the occupancy model, from the difference of the binding potential (BP) of PAC in two different conditions. The same subjects also participated in H_<2>^<15>O-PET with the same paradigm to evaluate the regional cerebral activation with the task in terms of regional cerebral blood flow change.
The left striatum was activated significantly with H_<2>^<15>5O-PET study with writing task. In the same region, the binding potentials of RAC was significantly reduced by dictation task, thus, the intrinsic dopamine release was considered to be accelerated by the task. The activated region located in the ventro-caudal portion of the putamen which we previosly reported to be corresponding to hand area in the sometotopic organization in the basal ganglia. This result demonstrated the ability of indirect measurement method of intrinsic dopamine release by RAC-PET in physiological condition. Our results are the first report of activation of dopaminergic neurons by a skilled voluntary monements.
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Research Products
(13 results)
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[Publications] Mishina, M., Senda, M., Kimura, Y., Toyama, H., Ishiwata, K., Ohyama, M., Nariai, T., Ishii, K., Oda, K., Sasaki, T., Kitamura, S. and Katayama, Y.: "Intrasubject correlation between static scan and distribution volume images for [11C]flumazenil PET."Ann Nucl Med,. 14(3). 193-198 (2000)
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「研究成果報告書概要(欧文)」より
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[Publications] Maillard, L., Ishii, K., Bushara, K., Waldvogel, D., Schulman, A. E. and Hallett, M.: "Mapping the basal ganglia -fMRI evidence for somatotopic representation of face, hand, and foot-"Neurology. 55. 377-383 (2000)
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[Publications] Xu, B., Grafman, J., Gaillard, W. D., Ishii, K., Vega-Bermudez, F., Pietrini, P., Reeves-Tyer, P., Dicamillo, P. and Theodore, W.: "Conjoint and extended neural networks for the computation of speech codes : The neurl basic of impairment in reading words and pseudowords."Cerebral Cortex.. (3). 267-277 (2001)
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「研究成果報告書概要(欧文)」より
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[Publications] Ishiwata, K., Ogi, N., Shimada, J., Wang, W.-F., Ishii, K., Tanaka, A., Suzuki, F. and Senda, M.: "Search for PET probes for imaging the globus pallidus studied with rat brain ex vivo autoradiography,"Ann Nucl Med,. 14(6). 461-466 (2000)
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[Publications] Nariai, T., Ohno, K., Ohta, Y., Hirakawa, K., Ishii, K. and Senda, M.: "Discordance between cerebral oxygen and glucose metabolism, and hemodynamics in a mitochondrial encephalomyopathy, lactic acidosis, and strokelike episode.patient"J Neuroimag,. 11(3). 325-329 (2001)
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