2001 Fiscal Year Final Research Report Summary
The effect of the hepatic blood flow on the amount of asialoglycoprotein receptors and the liver function.
| Project/Area Number |
12670893
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
FUJIMORI Kenji Sapporo Medical University, School of Medicine, Assistant Professor, 医学部, 講師 (80264539)
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| Project Period (FY) |
2000 – 2001
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| Keywords | Liver function / Asialoglycoprotein / Tc-99m-GSA |
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| Research Abstract |
^<99m>Tc-galactosyl human serum albumin (GSA) bounds an asialoglycoprotein receptor on the cell surface of hepatocyte and there seem to be two major factors which influence the liver uptake of ^<99m>Tc-GSA : the amount of receptors and the blood flow. ^<99m>Tc-GSA distributes homogeneously in the non-tumorous liver tissue, however, there are some cases to show focal decreased uptake in these tissues. Theoretical analysis was performed with the non-linear compartment model including blood flow and receptor amount to reveal the factors influencing liver uptake.
To evaluate the model feasibility, an animal model (rat) for a partial hepatic artery or portal vein ligation procedure has been tried to establish. Due to technical difficulties to monitor regional ^<99m>Tc-GSA concentration in the liver, no concrete result has been yet achieved in this term.
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Research Products
(12 results)
