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2002 Fiscal Year Final Research Report Summary

Neural mechanism of respiratory signal during general anesthesia

Research Project

Project/Area Number 12671460
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionGifu University

Principal Investigator

OSHIMA Tsutomu  University of Hospital Assistant Professor, 医学部附属病院, 講師 (50223805)

Co-Investigator(Kenkyū-buntansha) DOHI Shuji  School of Medicine Professor, 医学部, 教授 (40155627)
Project Period (FY) 2000 – 2002
KeywordsControl of breathing / Anesthesia / Neurotransmitter
Research Abstract

Several clinical and basic research projects were performed, thereby exhibiting the following findings.
1) Laryngoscopic observation revealed an active process in glottic closure during hiccups in human.
2) The work of breathing spent on the upstream segment of the nasal route increased during midazolam sedation and returned to baseline after flumazenil antagonism.
3) Tandospirone, 10 and 30 mg, safely reduced preoperative anxiety to a similar extent as oral diazepam 10 mg in patients undergoing elective otolaryngologic surgery.
4) Premedication with oral tandospirone is effective against postoperative nausea and vomiting in patients undergoing tympanoplasty under general anesthesia.
5) We proposed a phylogenetic perspective that sheds a new light on the origin and physiological significance of hiccups.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Oshima T, et al.: "Prevention of nausea and vomiting with tandospirone following tympanoplasty"Anesth Analg. 95. 1442-1445 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Straus C, et al.: "A phylogenetic hypothesis for the origin of hiccough"BioEssays. 25. 182-188 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大島 勉他: "GABA_Aレセプターとしゃっくり"臨床麻酔. 26. 1675-1679 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oshima T, et al.: "The anxiolytic effects of 5-Hydroxytryptamine 1A agoinsc thndospirone before otolaryngologic surgery"Anesth Analg. 93. 1214-1216 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oshima T, et al.: "Glottic adduction during hiccups in the presence of a cuffed endotracheal tube"Anesthesiology. 93. 910 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawauchi Y, Oshima T et al.: "Flumazenil abolishes midazolam-induced increase in work of nasal breathing"Can J Anesth. 47. 1216-1219 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oshima T, Nagase K, Dohi S: "Glottic adduction during hiccups in the presence of a cuffed endotracheal tube"Anesthesiology. 93. 910 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawauchi Y, Oshima T, Saitoh Y, Toyooka H: "Flumazenil abolishes midazolam-induced increase in work of nasal breathing"Can J Anesth. 47. 1216-1219 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oshima T, Kasuya Y, Terazawa E, Nagase K, Saitoh Y: "The anxiolytic effects of 5-Hydroxytryptamine-1A agonist tandospirone before otolaryngologic surgery"Anesth Analg. 93. 1214-1216 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oshima T, Kasuya Y, Okumura Y, Terazawa E, Dohi S: "Prevention of nausea and vomiting with tandospirone following tympanoplasty"Anesth Analg. 95. 1442-1445 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Straus C, Vasilakos K, Wilson RJA, Oshima T, Zelter M, Drenne JPh, Similowski T, Whitelaw WA: "A Phylogenetic hypothesis for the origin of hiccough"Bio Essays. 25. 182-188 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tutomu Oshima, Shuji Dohi: "GABAA Receptors and Hiccups (Japan)"Journal pf Clinical Anesthesia. 26. 1675-1679 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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