2001 Fiscal Year Final Research Report Summary
Suppression of tumor growth and metastasis via apoptosis induced specifically in endothelial cells by caspin/PEDF/EPC-1
| Project/Area Number |
12671975
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Aichi-Gakuin University |
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Principal Investigator |
KAWAI Toshihiko Aichi Gakuin University, School of Dentistry, Lecturer, 歯学部, 講師 (90201441)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Isamu Aichi Gakuin University, School of Dentistry, Research Associate, 歯学部, 助手 (50340154)
SAGA Shinsuke Aichi Medical University, School of Medicine, Professor, 医学部, 教授 (40144141)
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| Project Period (FY) |
2000 – 2001
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| Keywords | caspin / PEDF / EPC-1 / apoptosis / endothelial cell / angiogenesis / tumor growth / tumor metastasis |
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| Research Abstract |
We investigated the physiological and pathophysiological roles of caspin/PEDF/EPC-1 in tumor growth and metastasis as an inhibitor of angiogenesis. Supplement of recombinant caspin in the cultures evidently inhibited ex vivo outgrowth of microvessels from excised rat aorta and in vitro growth of cultured endothelial cells in a dose-dependent manner. Furthermore, we found that caspin can induce apoptosis specifically in endothelial cells, but not in any other type of cultured cells. These findings suggest that caspin/PEDF/EPC-1 regulates angiogenesis by inducing apoptosis of endothelial cells. Thus, this protein might play a crucial role in important biological events, in which tissue reconstruction with prominent angiogenesis is essentially required, such as embryogenesis, wound healing, and the formation of granulation tissue as well as tumor growth and metastasis.
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Research Products
(8 results)
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[Publications] Nakayashiki, N., Yoshikawa, K., Nakamura, K., Hanai, N., Okamoto, K., Okamoto, S., Mizuno, M., Wakabayashi, T., Saga, S., Yoshida, J. and Takahashi, T.: "Production of a single-chain variable fragment antibody recognizing type III mutant epidermal growth factor receptor"Jpn J Cancer Res.. 91. 1035-1043 (2000)
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[Publications] Azuma, M., Kojimab, T., Yokoyama, I., Tajiri, H., Yoshikawa, K., Saga, S. and Del, Carpio, CA.: "A synthetic peptide of human apoprotein E with antibacterial activity"Peptides. 21. 327-330 (2000)
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[Publications] Tsujimura, K., Obata, Y., Matsudaira, Y., Ozeki, S., Yoshikawa, K., Saga, S., Takahashi, T.: "The binding of thymus leukemia (TL) antigen tetramers to normal intestinal intraepithelial lymphocytes and thymocytes"J Immunol.. 167. 759-764 (2001)
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「研究成果報告書概要(欧文)」より
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