Molecular and Cellular biglogical study on the maxillotacial bone formation by orthognathic torce.

2001 Fiscal Year Final Research Report Summary

• Project/Area Number: 12671987
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 矯正・小児・社会系歯学
• Research Institution: The University of Tokyo
• Principal Investigator: SUSAMI Takafumi Facuulty of Medicin, The University of Tokyo, Associate professor, 医学部・附属病院, 助教授 (80179184)
• Co-Investigator(Kenkyū-buntansha): HIKIJI Hisako Facuulty of Health Center, The University of Tokyo, Associate professor, 保健センター, 講師 (50292876) ; KAWAGUCHI Hiroshi Facuulty of Medicin, The University of Tokyo, Assistant professor, 医学部・附属病院, 講師 (40282660) ; TAKATO Tsuyoshi Facuulty of Medicin, The University of Tokyo, professor, 医学部・附属病院, 教授 (90171454)
• Project Period (FY): 2000 – 2001
• Keywords: Pistraction osteogenesis / rat / radiodense / molecular and cellular biology

Research Abstract

Distraction osteogenesis is a powerful technique capable of generating viable osseous tissue by the gradual separation of osteotomized bone edges. Although the histologic and radiologic changes associated with this process have extensively delineated, the molecular events governing these changes remain essentially unknown. We have devised a rat model of mandibular distraction osteogenesis that facilitates molecular analysis of this process. Such information has significant clinical implications because it may enable targeted therapeutic manipulations designed to accelerate osseous regeneration. We have evaluated the macroscopic observations and radiographic changes in this study, and the bone in the distraction areas of the 4-week subgroups was radiodense, equivalent to the original bone. We examine the molecular and cellular biological study now.