2001 Fiscal Year Final Research Report Summary
Physiological Study on Conduction Block and anti GM1 Antibody in Multifocal Motor Neuropathy
| Project/Area Number |
12672356
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KAJI Ryuji Tokushima Univ. Hospital, Professor, 医学部・附属病院, 教授 (00214304)
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| Project Period (FY) |
2000 – 2001
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| Keywords | Multifocal Motor neuropathy / Conduction Block / Threshold Electrotonus / Anti-GM1 Antibody / Depolarization / Hyperpolarization / Fasciculation |
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| Research Abstract |
Conduction block is an important functional consequence of demyelination whereby nervous transmission is abolished. Its mechanism has been discussed with respect to the loss of insulation due to disruption ofmyelin. Recent development of threshold tracking techniques, enabling non-invasive assessment of axonal membrane potentials and ion channels, has provided evidence that axonal excitability changes significantly contribute to conduction failure. This study based upon axo-glial interaction clarifies the pathomechanism of muscle fatigue and fasciculation associated with peripheral demyelination, and possibly explains selective motor involvement in multifocal motor neuropathy.
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