Dynamics of signal transduction in the system of organogenesis and regeneration

2005 Fiscal Year Final Research Report Summary

• Project/Area Number: 13044003
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Institute for Basic Biology (2004-2005); Okazaki National Research Institutes (2001-2003)
• Principal Investigator: UENO Naoto National Institute for Basic Biology, Laboratory of Morphogenesis, Professor, 形態形成研究部門, 教授 (40221105)
• Co-Investigator(Kenkyū-buntansha): TAIRA Masanori University of Tokyo, Department of Biological Science, Associate Professor, 大学院理学研究科, 助教授 (60150083) ; NISHIDA Hiroki Osaka University, Department of Biology, Professor, 大学院理学研究科, 教授 (60192689) ; KOBAYASHI Satoru National Institutes of Natural Sciences (Okazaki Research Facilities), Okazaki Institute for Integrative Bioscience, Professor, 岡崎統合バイオサイエンスセンター, 教授 (90225508) ; TASHIRO Kousuke Kyushu University, Faculty of Agriculture, Associate Professor, 大学院生物資源環境科学研究科, 助教授 (00192170)
• Project Period (FY): 2001 – 2005
• Keywords: early development / embryonic induction / cell-to-cell interation / microarray / Xenopus laevis / Drosophila / germ cell / cell migration

Research Abstract

We performed a series of investigations involving systematic and comprehensive studies using model animals, to establish a platform for clarifying the machinery that controls early development consisting of complex cell-to- cell interactions "Early developmental systems" which we call and the relationship among their molecular components. We also carried out functional analyses of components (genes and proteins) identified by the analyses to ask their in vivo role in early embryogenesis. By the coordination of Naoto Ueno, Masanori Taira, and Kosuke Tashiro for using Xenopus laevis as a model system, construction of cDNA libraries, determination of nucleotide sequence of the cDNAs, fabrication of high-density microarray, comprehensive analyses of gene expression by the microarray during early development, spatial and temporal gene expression analysis, and construction of databases containing those information were achieved. Particularly, Ueno and Tashiro optimized the combined methodology of the high-density microarray and overexpression of polypeptide growth factors in embryos. Through the analyses which we established, Ueno and Taira focused on the regulation of gastrulation and head development, respectively, and investigate the function of the identified several genes essential for those developmental events. Satoru Kobayashi established a method of labeling germ cells specifically by expressing GFP under the regulation of a germ cell-specific promoter and germ cells were selected by cell- sorting. The microarray analysis of germ cell specific genes identified a number of genes implicated in germ cell differentiation, maintenance, and migration. It is noteworthy that a large group of genes that are predicted to be involved in one particular function was identified. Taken together these achievements prove that systematic and comprehensive analyses of genes are very effective to clarify the molecular network of early developmental processes.

Research Products

• [Journal Article] Roles of cascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell-derived vascular progenitor cells into endothelial cells. (2005)
  • Author(s): Suzuki, H., Watabe, T., Miyazawa, K., Kato M., Miyazono, K.
  • Journal Title: Blood 105 Pages: 2372-2379
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] FGF signal regulates gastrulation cell movements and morphology through its target NRH. (2005)
  • Author(s): Chung, H.A., Hyodo-Miura, J., Nagamune, T., Ueno, N.
  • Journal Title: Dev.Biol. 282 Pages: 95-110
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] POPK-1/Sad-1 kinasen is required for the proper translocation of maternal mRNAs and putative germ plasm at the posterior pole of the ascidian embryo. (2005)
  • Author(s): Nakamura, Y., Makabe, K.W., Nishida, H.
  • Journal Title: Development 132 Pages: 4731-4742
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of mitochondrial ribosome-dependent translation in germline formation in Drosophila embryos. (2005)
  • Author(s): Amikura, R., Sato, K., Kobayashi, S.
  • Journal Title: Mech.Dev. 122 Pages: 1087-1093
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos. (2005)
  • Author(s): Koshida, S., Kishimoto, Y., Ustumi, H., Shimizu, T., Furutani-Seiki, M., Kondoh, H., Takada, S.
  • Journal Title: Dev.Cell 8 Pages: 587-598
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Drosophila caspase transduces Shaggy/GSK-3b kinase activity in neural precuorsor development. (2005)
  • Author(s): Kanuka, H., Kuranaga, E., Takemoto, K., Hiratou, T., Okano, H., Miura, M.
  • Journal Title: EMBO J. 24 Pages: 3793-3806
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential roles for SOX15 and SOX2 in transcriptional control in mouse embryonic stem cells. (2005)
  • Author(s): Maruyama, M., Ichisaka, T., Nakagawa, M., Yamanaka, S.
  • Journal Title: J.Biol.Chem. 280 Pages: 24371-9
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell-derived vascular progenitor cells into endothelial cells. (2005)
  • Author(s): Suzuki, H., Watabe, T., Miyazawa, K., Kato, M., *Miyazono, K.
  • Journal Title: Blood 105 Pages: 2372-2379
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] FGF signal regulates gastrulation cell movements and morphology through its target NRH. (2005)
  • Author(s): Chung, H.A., Hyodo-Miura, J., Nagamune, T., *Ueno, N.
  • Journal Title: Dev. Biol. 282 Pages: 95-110
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of Crescent in convergent extension movements by modulating Wnt signaling in early Xenopus embryogenesis. (2005)
  • Author(s): Shibata, M., Itoh, M., Hikasa, H., Taira, S., *Taira, M.
  • Journal Title: Mech. Dev. 122 Pages: 1322-1339
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] POPK-1/Sad-1 kinase is required for the proper translocation of maternal mRNAs and putative germ plasm at the posterior pole of the ascidian embryo. (2005)
  • Author(s): Nakamura, Y., Makabe, K.W., *Nishida, H.
  • Journal Title: Development 132 Pages: 4731-4742
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of mitochondrial ribosome-dependent translation in germline formation in Drosophila embryos. (2005)
  • Author(s): Amikura, R., Sato, K., *Kobayashi, S.
  • Journal Title: Mech. Dev. 122 Pages: 1087-1093
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos. (2005)
  • Author(s): Koshida, S., Kishimoto, Y., Ustumi, H., Shimizu, T., Furutani-Seiki, M., Kondoh, H., *Takada, S.
  • Journal Title: Dev. Cell 8 Pages: 587-598
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Drosophila caspase transduces Shaggy/GSK-3b kinase activity in neural precuorsor development. (2005)
  • Author(s): Kanuka, H., Kuranaga, E., Takemoto, K., Hiratou, T., Okano, H., *Miura, M.
  • Journal Title: EMBO J. 24 Pages: 3793-3806
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential roles for SOX15 and SOX2 in transcriptional control in mouse embryonic stem cells. (2005)
  • Author(s): Maruyama, M., Ichisaka, T., Nakagawa, M., *Yamanaka, S.
  • Journal Title: J. Biol. Chem. 280 Pages: 24371-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Screening of FGF target genes in Xenopus by microarray : temporal dissection of the signalling pathway using a chemical inhibitor. (2004)
  • Author(s): Chung, H.A., Hyodo-Miura, J., Kitayama, A., Terasaka, C., Nagamune, T., Ueno, N.
  • Journal Title: Genes Cells 9 Pages: 749-761
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Tracing cell fate in brain formation during embryogenesis of the ascidian Halocynthia roretzi. (2004)
  • Author(s): Tanigushi, K., Nishida, H.
  • Journal Title: Dev.Growth Differ. 46 Pages: 163-180
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nanos suppresses somatic cell fate in Drosophila germline. (2004)
  • Author(s): Hayashi, Y., Hayashi, M., Kobayashi, S.
  • Journal Title: Proc.Natl.Acad.Sci.USA 101 Pages: 10338-19342
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish. (2004)
  • Author(s): Kawakami, K., Takeda, H., Kawakami, N., Kobayashi, M., Matsuda, N., Mishina, M.
  • Journal Title: Developmental Cell 7 Pages: 133-144
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The POU domain protein Spg (Pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein Casanova. (2004)
  • Author(s): Reim, G., Mizoguchi, T., Stainier, D.Y.R., Kikuchi, Y., Brand, M.
  • Journal Title: Developmental Cell 6 Pages: 91-101
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Spatio-temporal activation caspase revealed by indicator that is insensitive to environmental effects. (2004)
  • Author(s): Takemoto, K., Nagai, T., Miyawaki, A., Miura, M.
  • Journal Title: J.Cell Biol. 160 Pages: 235-243
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo. (2004)
  • Author(s): Yamamoto, M., Saijoh, Y., Perea-Gomez, A., Shawlot, W., Behringer RR., Ang SL., Hamada, H., Meno, C.
  • Journal Title: Nature 428 Pages: 387-392
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Screening of FGF target genes in Xenopus by microarray : temporal dissection of the signalling pathway using a chemical inhibitor. (2004)
  • Author(s): Chung, H.A., Hyodo-Miura, J., Kitayama, A., Terasaka, C., Nagamune, T., *Ueno, N.
  • Journal Title: Genes Cells 9 Pages: 749-761
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Tracing cell fate in brain formation during embryogenesis of the ascidian Halocynthia roretzi. (2004)
  • Author(s): Taniguchi, K., *Nishida, H.
  • Journal Title: Dev. Growth Differ. 46 Pages: 163-180
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nanos suppresses somatic cell fate in Drosophila germline. (2004)
  • Author(s): Hayashi, Y., Hayashi, M., *Kobayashi, S.
  • Journal Title: Proc. Natl. Acad. Sci. USA 101 Pages: 10338-10342
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects. (2004)
  • Author(s): Takemoto, K., Nagai, T., Miyawaki, A., *Miura, M.
  • Journal Title: J. Cell Biol. 160 Pages: 135-243
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo. (2004)
  • Author(s): Yamamoto, M., Saijoh, Y., Perea-Gomez, A., Shawlot, W., Behringer RR., Ang SL., *Hamada, H., Meno, C.
  • Journal Title: Nature 428 Pages: 387-392
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Zic2 patterns binocular vision by specifying the uncrossed retinal projection. (2003)
  • Author(s): Herrera, E., Brown L., Aruga, J., Rachel, R.A., Dolen, G., Mikoshiba, K., Brown, S., Mason, C.A.
  • Journal Title: Cell 114 Pages: 545-557
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Interplay between the tumor suppressor p53 and TGF-b signaling shapes embryonic body axes in Xenopus. (2003)
  • Author(s): Takebayashi-Suzuki, K., Funami, J., Tokumori, D., Saito, A., Watabe, T., Miyazono, K., Kanda, A., Suzuki, A.
  • Journal Title: Development 130 Pages: 3929-3939
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. (2003)
  • Author(s): Bessho, Y., Hirata, H., Masamizu, Y., Kageyama, R.
  • Journal Title: Genes Dev. 17 Pages: 1451-1456
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects. (2003)
  • Author(s): Takemoto, K., Nagai, T., Miyawaki, A., Miura, M.
  • Journal Title: J.Cell Biol. 160 Pages: 235-243
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. (2003)
  • Author(s): Yamamoto, M., Mine, N., Mochida, K., Sakai, Y., Saijoh, Y., Meno, C., Hamada, H.
  • Journal Title: Development 130 Pages: 1795-1804
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The homeoprotin Nanog is required for maintenance of pluriopotency in mouse epiblast and ES cells. (2003)
  • Author(s): Mitsui, K., Tokuzawa, Y., Itoh, H., Segawa, K., Murakami, M., Takahashi, K., Murayama, M., Maeda, M., Yamanaka, S.
  • Journal Title: Cell 113 Pages: 631-642
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. (2003)
  • Author(s): Ohkawara, B., Yamamoto, T., Tada, M., Ueno, N.
  • Journal Title: Development 130 Pages: 2129-2138
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions. (2003)
  • Author(s): Hiratani, I., Yamamoto, N., Mochizuki, T., Ohmoro, S., Taira, M.
  • Journal Title: Development 130 Pages: 4161-4175
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Maternal macho-1 is an intrinsic factor that maker cell response to the same FGF signal differ between mesenchyme and notochord induction in ascidian embryos. (2003)
  • Author(s): Kobayashi, K., Sawada, K., Yamamoto, H., Wada, S., Saiga, H., Nishida H.
  • Journal Title: Science 130 Pages: 5179-5190
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Conserved role of nanos proteins in germ cell development. (2003)
  • Author(s): Tsuda, M., Sasaoka, Y., Kiso, M., Abe, K., Haraguchi, S., Kobayashi, S., Saga, Y.
  • Journal Title: Science 301 Pages: 1239-1241
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Bayesian network and nonparametric heteroscedastic regeression for nonlinear modeling of genetic network. (2003)
  • Author(s): Imoto, S., Kim, S., Goto, T., Aburatani, S., Tashiro, K., Kuhara, S., Miyano, S.
  • Journal Title: J.Bioinformatics＆Computational Bio. 1 Pages: 231-252
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Zic2 patterns binocular vision by specifying the uncrossed retinal projection. (2003)
  • Author(s): Herrera, E., Brown L., Aruga, J., Rachel, R.A., Dolen, G., Mikoshiba, K., Brown, S., *Mason, C.A.
  • Journal Title: Cell 114 Pages: 545-557
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects. (2003)
  • Author(s): Takemoto, K., Nagai, T., Miyawaki, A., *Miura, M.
  • Journal Title: J. Cell Biol. Pages: 160-235-243
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. (2003)
  • Author(s): Yamamoto, M., Mine, N., Mochida, K., Sakai, Y., Saijoh, Y., Meno, C., *Hamada, H.
  • Journal Title: Development 130 Pages: 1795-1804
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The homeoprotin Nanog is required for maintenance of pluriopotency in mouse epiblast and ES cells. (2003)
  • Author(s): Mitsui, K., Tokuzawa, Y., Itoh, H., Segawa, K., Murakami, M., Takahashi, K., Murayama, M., Maeda, M., *Yamanaka, S.
  • Journal Title: Cell 113 Pages: 631-642
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. (2003)
  • Author(s): Ohkawara, B., Yamamoto, T., Tada, M., *Ueno, N.
  • Journal Title: Development 130 Pages: 2129-2138
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Selective degradation of excess Ldbl by Rnfl2/RLIM confers proper Ldbl expression levels and Xlim-1/Ldbl stoichiometry in Xenopus organizer functions. (2003)
  • Author(s): Hiratani, I., Yamamoto, N., Mochizuki, T., Ohmoro, S., *Taira, M.
  • Journal Title: Development 130 Pages: 4161-4175
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Maternal macho-1 is an intrinsic factor that makes cell response to the same FGF signal differ between mesenchyme and notochord induction in ascidian embryos. (2003)
  • Author(s): Kobayashi, K., Sawada, K., Yamamoto, H., Wada, S., Saiga, H., *Nishida H
  • Journal Title: Development 130 Pages: 5179-5190
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Conserved role of nanos proteins in germ cell development. (2003)
  • Author(s): Tsuda, M., Sasaoka, Y., Kiso, M., Abe, K., Haraguchi, S., Kobayashi, S., *Saga, Y.
  • Journal Title: Science 301 Pages: 1239-1241
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bayesian network and nonparametric heteroscedastic regeression for nonlinear modeling of genetic network. (2003)
  • Author(s): Imoto, S., Kim, S., Goto, T.Aburatani, S., Tashiro, K., Kuhara, S., Miyano, S.
  • Journal Title: J.Bioinformatics＆Computational Bio. 1 Pages: 231-252
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Low density detergent-insoluble membrane of Xenopus eggs : Subcellular microdomain for tyrosine kinase signaling in fertilization. (2002)
  • Author(s): Sato, K., Iwasaki, T., Ogawa, K., Konishi, M., Tokmakov, A.A., Fukami, Y.
  • Journal Title: Development 129 Pages: 885-896
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Action range of BMP is defined by its N-terminal basic amino acid core. (2002)
  • Author(s): Ohkawara, B., Iemura, S.-I., ten Dijke, P., Ueno, N.
  • Journal Title: Curr. Biol. 12 Pages: 1-20
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A C.elegans TGF-b, DBL-1, controls the exoression of LON-1 that regulates polyploidization and body length. (2002)
  • Author(s): Morita, K., Flemming, A., Sugihara, Y., Mochii, M., Suzuki, Y., Yoshida, S., Wood, B., Kohara, Y., Leroi, A.M., UenoN.
  • Journal Title: EMBO J. 21 Pages: 1063-1073
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling. (2002)
  • Author(s): Hikasa, H., Shibata, M., Hiratani, I., Taira, M.
  • Journal Title: Development 129 Pages: 5227-5239
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Notch signaling is involved in neurogenesis in the ascidian embryos. (2002)
  • Author(s): Akanuma, T., Hori, S., Darras, S., Nishida, H.
  • Journal Title: Dev.Genes Evol 212 Pages: 249-472
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification of a transcriptional regulatory region for germline-specific expression of vasa gene in Drosophila melanogaster. (2002)
  • Author(s): Sano, H., Nakamura, A., Kobayashi, S.
  • Journal Title: Mech.Dev. 112 Pages: 129-139
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. (2002)
  • Author(s): Dai, P., Shinagawa, T., Nomura, T., Harada, J., Kaul, S.C., Wadhwa, R.Akimaru, H., Sasaki, H., Colmenaes, C., Ishii, S.
  • Journal Title: Dev. 16 Pages: 2843-2848
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A. Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway. (2002)
  • Author(s): Kobayashi, M., Kishida, S., Fukui, A., Michiue, T., Miyamoto, Y., Okamoto, T., Yoneda, Y., Asashima, M., Kikuchi
  • Journal Title: J.Biol.Chem. 277 Pages: 5816-5822
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differentiation of embryonic stem cells is induced by GATA factors. (2002)
  • Author(s): Fujikura, F., Yamamoto, e., Yonemura, S., Hosoda, K., Masui, S., Nakao, K., Miyazaki, J.-I., Niwa, H.
  • Journal Title: Genes Dev. 16 Pages: 784-789
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oscillatory expression of the bHLH factor Hesl regulated by a negative feedback loop (2002)
  • Author(s): Hirata, H., Yoshiura, S., Ohtsuka, T., Bessho, Y., Harada, T., Yoshikawa, K., Kageyama, R.
  • Journal Title: Science 298 Pages: 840-843
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Reaper-mediated inhibition of DIAP1-induced Drosophila TRAF1 degradation leads to JNK activation. (2002)
  • Author(s): Kuranaga, E., Kanuka, H., Igaki, T., Sawamoto, K., Ichijo, H., Okano, H., Miura, M.
  • Journal Title: Nature Cell Biol. 4 Pages: 705-710
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila. (2002)
  • Author(s): Yanagawa, S., Matsuda, Y., Lee, JS., Matsubayashi, H., Sese, S., Kadowaki, T., Ishimoto, A.
  • Journal Title: EMBO J. 21 Pages: 1733-1742
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Action range of BMP is defined by its N-terminal basic amino acid core. (2002)
  • Author(s): Ohkawara, B., Iemura, S.-L, ten Dijke, P., *Ueno.N.
  • Journal Title: Curr. Biol. 12 Pages: 1-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] elegans TGF- b, DBL-1, controls the expression of LON-1 that regulates polyploidization and body length. (2002)
  • Author(s): Morita, K., Flemming, A., Sugihara, Y., Mochii, M., Suzuki, Y.Yoshida, S., Wood, B., Kohara, Y., Leroi, A.M., *Ueno N.A C.
  • Journal Title: EMBO J. 21 Pages: 1063-1073
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling. (2002)
  • Author(s): Hikasa, H., Shibata, M., Hiratani, I., *Taira, M.
  • Journal Title: Development 129 Pages: 5227-5239
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Notch signaling is involved in neurogenesis in the ascidian embryos. (2002)
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  • Journal Title: Dev. Genes Evol. 212 Pages: 249-472
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• [Journal Article] Identification of a transcriptional regulatory region for germline-specific expression of vasa gene in Drosophila melanogaster. (2002)
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  • Journal Title: Mech. Dev. 112 Pages: 129-139
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• [Journal Article] Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. (2002)
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• [Journal Article] Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway. (2002)
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• [Journal Article] Differentiation of embryonic stem cells is induced by GATA factors. (2002)
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  • Journal Title: Genes Dev. 16 Pages: 784-789
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• [Journal Article] Oscillatory expression of the bHLH factor Hesl regulated by a negative feedback loop. (2002)
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• [Journal Article] Reaper-mediated inhibition of DIAP1-induced Drosophila TRAF1 degradation leads to JNK activation. (2002)
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  • Journal Title: Nature Cell Biol 4 Pages: 705-710
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• [Journal Article] Presence of mitochondria-type ribosomes outside mitochndria in germ olasm of Drosophila embryos. (2001)
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• [Journal Article] Systematic screening and expression analysis of the head organizer genes in Xenopus embryos. (2001)
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  • Journal Title: Dev.Biol. 239 Pages: 241-256
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] In synergy with Noggin and Follistatin, Xenopus Nodal-related gene induces sonic hedgehog on notochord and floor plate. (2001)
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• [Journal Article] macho-l encodes localized mRNA in ascidian eggs that specifies muscle fate during embryogenesis. (2001)
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• [Journal Article] Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex during Drosophilaoogenesis. (2001)
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• [Journal Article] The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. (2001)
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• [Journal Article] Presence of mitochondria-type ribosomes outside mitochondria in germ plasm of Drosophila embryos. (2001)
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• [Journal Article] Systematic screening and expression analysis of the head organizer genes in Xenopus embryos. (2001)
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• [Journal Article] In synergy with Noggin and Follistatin, Xenopus Nodal-related gene induces sonic hedgehog on notochord and floor plate. (2001)
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  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] macho-1 encodes localized mRNA in ascidian eggs that specifies muscle fate during embryogenesis. (2001)
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  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex during Drosophila oogenesis. (2001)
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  • Journal Title: Development 128 Pages: 3233-3242
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. (2001)
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• [Journal Article] Role of Crescent in convergent extension movements by modulating Wnt signaling in early Xenopus embryogenesis.
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