2001 Fiscal Year Annual Research Report

感染の成立と宿主応答の分子基盤

Research Project

Project/Area Number	13225001
Research Category	Grant-in-Aid for Scientific Research on Priority Areas (C)
Research Institution	Nagoya University
Principal Investigator	永井美之名古屋大学, 名誉教授 (20022874)
Co-Investigator(Kenkyū-buntansha)	柳雄介九州大学, 大学院・医学研究院, 教授 (40182365) 菅村和夫東北大学, 大学院・医学系研究科, 教授 (20117360) 審良静男大阪大学, 微生物病研究所, 教授 (50192919) 吉開泰信名古屋大学, 大学院・医学研究科, 教授 (90158402) 堀井俊宏大阪大学, 微生物病研究所, 教授 (80142305)
Keywords	感染 / 宿主応答 / 評価・助言 / 企画実施 / 研究支援 / 研究推進
Research Abstract	総括班は本特定領域研究の目的を厳正かつ遅滞なく達成するために組織された。本年度は研究の実施にあたって各研究項目間、班員間の共同研究、国際情報ネットワークの構築、若手研究者の支援、また、コホートの形成や感染動物実験施設運営の支援、などの重要事項を総括した。総括班会議、合同班会議、企画実施委員会を開催して、班および班員間の交流、共同研究の推進、国の内外における広汎な情報交換を行い、感染症・宿主応答研究の推進に適切な提言と研究基盤の形成に必要な措置を取った。本特定領域を円滑に推進するために、総括班においては上部委員会として評価委員会及び企画実施委員会を設けるとともに、各種委員会を設置した。 ○評価・助言委員会:領域代表者と外部の有識者を加えた評価委員会を設け、研究領域全般の評価と助言を行った。 ○企画実施委員会:領域代表者と各研究項目の班長および、総括班に設置される各委員会の委員長よりなる企画実施委員会を頻繁に開催し、研究領域全体の企画調整、推進方策の検討を行った。また、全体班会議で各研究課題の五段階評価を行い、現状の正確な把握と次年度企画や組織方針策定の参考とした。 ○対外委員会:<広報委員会>、<国際社会との接点委員会>、<産学連携・協力委員会>を設け、電子媒体による研究成果の公表と研究ネットワーク作りをおこない、情報公開・発信の効率化を目指した。 ○研究支援委員会(リソース委員会):<実験施設等の整備支援委員会>、<コホート研究支援委員会>、<若手支援・育成委員会>を設けた。 ○研究推進委員会:<ゲノム/プロテオーム委員会>、<ウイルス感染・免疫研究推進委員会>、<細菌感染・免疫研究推進委員会>、<寄生虫感染・免疫研究推進委員会>を設け、研究推進を図った。

Research Products

(20 results)

All Other

All Publications (20 results)

[Publications] Masaki, I.: "Recombinant Sendai virus-mediated gene transfer to vasculature : a new class of efficient gene transfer vector to the vascular system"FASEB J.. 15. 1294-1296 (2001)
[Publications] Shinoda, T.: "A naturally occurring deletional mutation in the C-terminal cytoplasmic tail of CCR5 affects surface trafficking of CCR5"J.Virol.. 75. 3462-3468 (2001)
[Publications] Kato, A.: "Y2, the smallest of Sendai virus C proteins is fully capable of counteracting the ante-viral action of interferons and inhibiting viral RNA synthesis"J. Virol.. 75. 3802-3810 (2001)
[Publications] Mori, K.: "A quintuple deglycosylation mutant of SIVmac239 rhesus macaques : Robust primary replication severely impaired chronic infection and elicitation of potent immunity against the wild-type strain"J. Virol.. 75. 4023-4028 (2001)
[Publications] Sato, H.: "Augmentation of HIV subtype E (CRF01_AE) multiple-drug resistance by insertion of a foreign 11-amino-acid fragment into the reverce transcriptase"J. Virol.. 75. 5604-5613 (2001)
[Publications] Matano, T.: "Rapid appearance of secondary immune responses and protection from acute CD4 depletion after a highly pathogenic immunodeficiency virus challenge in macaques vaccinated with a DNA prime Sendai virus vector boost regimen]"J. Virol.. 75. 11891-11896 (2001)
[Publications] Kaisho, T.: "Immunology : Bug detectors"Nature. 414. 701-703 (2001)
[Publications] Ishii, N.: "Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice"Mol. Cell. Biol.. 21. 8626-8637 (2001)
[Publications] Ndhlovu, L.C.: "Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis"J. Immunol.. 167. 2991-2999 (2001)
[Publications] Okech, B.A.: "Natural human immunoglobulin G subclass responses to Plasmodium falciparum serine repeat antigen in Uganda"Am. J. Trop. Med. Hyg.. 65. 912-917 (2001)
[Publications] Tatsuo, H.: "Nucleotide, Protein Morbilliviruses use signaling lymphocyte activation molecules (CD150) as cellular receptors"J. Virol.. 75. 5842-5850 (2001)
[Publications] Ono, N.: "Measles viruses on throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not CD46 as a cellular receptor"J. Virol.. 75. 4399-4401 (2001)
[Publications] Ono, N.: "V domain of human SLAM (CDw150) is essential for its function as a measles virus receptor"N. Virol.. 75. 1594-1600 (2001)
[Publications] Nakayama, J.: "Gelatinase biosynthesis-activating pheromone : a peptide lactone that mediates a quorum sensing in Enterococcus faecailis"Mol. Microbiol.. 41. 145-154 (2001)
[Publications] Masuda, A.: "Interleukin-15 prevents mouse mast cells from apoptosis through STAT6-mediated Bcl-xL Expression"J. Biol. Chem.. 276. 26107-26113 (2001)
[Publications] Matsuguchi, T.: "A novel MAP kinase phosphatase is an important negative regulator of LPS-mediated JNK activation in mouse macrophage cell lines"Mol. Cell. Biol.. 21. 6999-7009 (2001)
[Publications] Yamashita, A.: "Fibroblast growth factor-2 determines severity of joint disease in adjuvant-induced arthritis in rats"J. Immunol.. 168. 450-457 (2002)
[Publications] Sakaguchi, T.: "Alteration of Sendai virus morphogenesis and nucleocapsid incoration due to mutation of cycteine residues of the matrix protein"J. Virol.. 76. 1682-1690 (2002)
[Publications] Yajima, T.: "Overexpression of IL-15 in vivo increases antigen-driven memory CD8+T cells following a microbe exposure"J. Immunol.. 168. 1198-1203 (2002)
[Publications] Hemmi, H.: "Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway"Nat Immunol.. 196-200. (2002)

2001 Fiscal Year Annual Research Report

感染の成立と宿主応答の分子基盤

Principal Investigator

永井 美之 名古屋大学, 名誉教授 (20022874)

Research Products

[Publications] Masaki, I.: "Recombinant Sendai virus-mediated gene transfer to vasculature : a new class of efficient gene transfer vector to the vascular system"FASEB J.. 15. 1294-1296 (2001)

[Publications] Shinoda, T.: "A naturally occurring deletional mutation in the C-terminal cytoplasmic tail of CCR5 affects surface trafficking of CCR5"J.Virol.. 75. 3462-3468 (2001)

[Publications] Kato, A.: "Y2, the smallest of Sendai virus C proteins is fully capable of counteracting the ante-viral action of interferons and inhibiting viral RNA synthesis"J. Virol.. 75. 3802-3810 (2001)

[Publications] Mori, K.: "A quintuple deglycosylation mutant of SIVmac239 rhesus macaques : Robust primary replication severely impaired chronic infection and elicitation of potent immunity against the wild-type strain"J. Virol.. 75. 4023-4028 (2001)

[Publications] Sato, H.: "Augmentation of HIV subtype E (CRF01_AE) multiple-drug resistance by insertion of a foreign 11-amino-acid fragment into the reverce transcriptase"J. Virol.. 75. 5604-5613 (2001)

[Publications] Matano, T.: "Rapid appearance of secondary immune responses and protection from acute CD4 depletion after a highly pathogenic immunodeficiency virus challenge in macaques vaccinated with a DNA prime Sendai virus vector boost regimen]"J. Virol.. 75. 11891-11896 (2001)

[Publications] Kaisho, T.: "Immunology : Bug detectors"Nature. 414. 701-703 (2001)

[Publications] Ishii, N.: "Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice"Mol. Cell. Biol.. 21. 8626-8637 (2001)

[Publications] Ndhlovu, L.C.: "Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis"J. Immunol.. 167. 2991-2999 (2001)

[Publications] Okech, B.A.: "Natural human immunoglobulin G subclass responses to Plasmodium falciparum serine repeat antigen in Uganda"Am. J. Trop. Med. Hyg.. 65. 912-917 (2001)

[Publications] Tatsuo, H.: "Nucleotide, Protein Morbilliviruses use signaling lymphocyte activation molecules (CD150) as cellular receptors"J. Virol.. 75. 5842-5850 (2001)

[Publications] Ono, N.: "Measles viruses on throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not CD46 as a cellular receptor"J. Virol.. 75. 4399-4401 (2001)

[Publications] Ono, N.: "V domain of human SLAM (CDw150) is essential for its function as a measles virus receptor"N. Virol.. 75. 1594-1600 (2001)

[Publications] Nakayama, J.: "Gelatinase biosynthesis-activating pheromone : a peptide lactone that mediates a quorum sensing in Enterococcus faecailis"Mol. Microbiol.. 41. 145-154 (2001)

[Publications] Masuda, A.: "Interleukin-15 prevents mouse mast cells from apoptosis through STAT6-mediated Bcl-xL Expression"J. Biol. Chem.. 276. 26107-26113 (2001)

[Publications] Matsuguchi, T.: "A novel MAP kinase phosphatase is an important negative regulator of LPS-mediated JNK activation in mouse macrophage cell lines"Mol. Cell. Biol.. 21. 6999-7009 (2001)

[Publications] Yamashita, A.: "Fibroblast growth factor-2 determines severity of joint disease in adjuvant-induced arthritis in rats"J. Immunol.. 168. 450-457 (2002)

[Publications] Sakaguchi, T.: "Alteration of Sendai virus morphogenesis and nucleocapsid incoration due to mutation of cycteine residues of the matrix protein"J. Virol.. 76. 1682-1690 (2002)

[Publications] Yajima, T.: "Overexpression of IL-15 in vivo increases antigen-driven memory CD8+T cells following a microbe exposure"J. Immunol.. 168. 1198-1203 (2002)

[Publications] Hemmi, H.: "Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway"Nat Immunol.. 196-200. (2002)

永井美之名古屋大学, 名誉教授 (20022874)