Molecular Bases underlying Microbial Infections and the Host Responses

2006 Fiscal Year Final Research Report Summary

• Project/Area Number: 13225001
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The Institute of Physical and Chemical Research (2006); Toyama Institute of Health (2003-2005); Nagoya University (2001-2002)
• Principal Investigator: NAGAI Yoshiyuki The Institute of Physical and Chemical Research, Research Center for Allergy and Immunology, Senior Scientist, 免役・アレルギー科学総合センター, 上級研究員 (20022874)
• Co-Investigator(Kenkyū-buntansha): AKIRA Shizuo Osaka University, Research Institute for Microbial Diseases, Professor, 微生物病研究所, 教授 (50192919) ; SUGAMURA Kazuo Tohoku University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (20117360) ; YANAGI Yusuke Kyushu University, Graduate School of Medicine, Professor, 大学院医学系研究院, 教授 (40182365) ; YOSHIKAI Yasunobu Kyushu University, Medical Institute of Bioregulation, Professor, 大学院医学系研究院, 教授 (90158402) ; HORII Toshihiro Osaka University, Research Institute for Microbial Diseases, Professor, 微生物病研究所, 教授 (80142305)
• Project Period (FY): 2001 – 2006
• Keywords: Infection / Host r Response / evaluation / advice / planning / support / coordination

Research Abstract

Our priority area aimed to conduct the highest quality research on the molecular bases of infections and the host responses and to advance technologies for infection control. To achieve these goals, we organized the leaders/advisors committee that was tasked to provide the theoretical and practical guidelines to the participating scientists and to evaluate their research outcomes. The committee not only emphasized the quality of research but also encouraged joint efforts by the members with different scientific disciplines and backgrounds (e.g. microbiology and immunology). The committee annually hosted the general assembly of the members, in which their research outcomes of the year were presented and evaluated. It further strove to financially support generation of genetically engineered mice and the studies using of nonhuman primates and to hold the Okinawa Forum and other small meetings for young researchers in view of human resource development. In the fiscal years 2004-2005, 45 planned research themes and 100 themes selected by public recruiting were supported by this priority area. Overall, a total of 3,993 papers were published or are in press in peer reviewed international journals during its five-year implementation. Of these, not a few were in high ranked journals (e.g. 27 are in Nature, 17 in Science, 35 in EMBO J., 101 in JEM and 87 in PNAS), and included excellent joint jobs of microbiologists and immunologists. The research outcomes were also disseminated to scientific community through Awaji International Forum on Infection and Immunity (annually 2002-2003) and International Symposium : Molecular Bases Underlying Microbial Infections and the Host Responses (2005). Conducted as a way to return the research profits to public health were the preclinical trials of N89 anti-malarial drug and DNA/Sendai vector based AIDS vaccine, and phase I clinical trials of SE36 malaria vaccine and anti-AIDS drug, AK602.

Research Products

• [Journal Article] Mycobacterial mammalian cell entry protein 1A (Mce1A contributes to induction of chemokine and proinflammtory cytokine expressions in A549 alveolar epithelial cells. (2007)
  • Author(s): Kohwiwattanagun J 他3名
  • Journal Title: Microbiol. Immunol. 51 Pages: 253-261
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mycobacterium tuberculosis H37Rv is capable of inhibiting necrosis of the infected macrophages via activation of caspase-9. (2007)
  • Author(s): Uchiyama R 他10名
  • Journal Title: Infect. Immun. 75 (In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Critical involvement of domain 4 of listeriolysin O and allied bacterial cytolysins in temperature- and pH-dependent loss of cytolytic activity. (2007)
  • Author(s): Nomura T 他7名
  • Journal Title: Microbiology 153 (In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cytolysin-dependent endosomal escape is required but not sufficient for the induction of Th1 immune response against Listeria infection : A distinct role for listerilysin O as determined by cytolysin gene replacement. (2007)
  • Author(s): Hara H 他4名
  • Journal Title: Infect. Immun. (In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] RD1 region in mycobacterial genome is involved in induction of necrosis in the infected RAW264 cells via mitochondrial membrane damege and ATP depletion. (2007)
  • Author(s): Kaku T 他4名
  • Journal Title: FEMS Microbiol. Lett. (In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Enforced expression of Bcl-2 restores numbers but not functions of TCRγσ intestinal intraepithelial T lymphocytes in IL-15-deficient mice (2007)
  • Author(s): Nakazato K et al.
  • Journal Title: J. Immunol 178 Pages: 757-64
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Peptide-pulsed dendritic cells for MHC class Ib-restricted CD8+T cells confer protection against Mycobacterium tuberculosis (2007)
  • Author(s): Doi T, et al.
  • Journal Title: J. Immunol 178 Pages: 3806-13
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Resident VσT cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production (2007)
  • Author(s): Shibata K., et al.
  • Journal Title: J. Immunol 178 Pages: 4466-4472
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Tyk2 signaling is important for Contraction of Antigen-Specific CD8^+T Cells Following a Microbial Infection (2007)
  • Author(s): Li W et al.
  • Journal Title: J. Immunol 178 Pages: 4482-4488
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Shigella chromosomal IpaH proteins are secreted via the type III secretion system and act as effectors. (2007)
  • Author(s): Ashida, H. et al.
  • Journal Title: Mol. Microbiol. 63 Pages: 680-693
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasin. (2007)
  • Author(s): Suzuki, T. et al.
  • Journal Title: J. Immunol 177 Pages: 4709-4717
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Shigella and Autophagy. (2007)
  • Author(s): Ogawa, M. et al.
  • Journal Title: Autophagy 2 Pages: 171-174
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] New animal model of shigellosis in the Guinea pig : its usefulness for protective efficacy studies. (2007)
  • Author(s): Shim, D.H.et al.
  • Journal Title: J. Immunol. 178 Pages: 2476-2482
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Enforced expression of Bcl-2 restores numbers but not functions of TCRgd intestinal intraepithelial T lymphocytes in IL-15-deficient mice (2007)
  • Author(s): Nakazato K., Yamada H., Yajima T., Kagimoto Y., Kuwano H., Yoshikai Y
  • Journal Title: J. Immunol. 178 Pages: 757-64
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Peptide-pulsed dendritic ells for MHC class Ib-restricted CD8+T cells confer protection against Mycobacterium tuberculosis (2007)
  • Author(s): Doi T, Yamada H., Yajima T., Wajjwalku W., Hara H., Yoshikai Y.
  • Journal Title: J. Immunol 178 Pages: 3806-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Resident Vβ1+ yβ T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production (2007)
  • Author(s): Shibata K., Yamada H., Hara H., Kishihara K., Yoshikai Y.
  • Journal Title: J. Immunol 178 Pages: 4466-4472
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Tyk2 signaling is important for contraction of antigen-specific CD8+1' Cells following a microbial infection (2007)
  • Author(s): Li W., Yamada H., Yajima T., Nakagawa R., Shimoda K., Nakayama K., Yoshikai Y
  • Journal Title: J. Immunol. 178 Pages: 4482-4488
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mycobacterial mammalian cell entry protein 1A (Mce1A) contributes to induction of chemokine and proinflammtory cytokine expressions in A549 alveolar epithelial cells. (2007)
  • Author(s): Kohwiwattanagun J, Kawamura I, Fujimura T, Mitsuyama M
  • Journal Title: Microbiol. Immunol. 51 Pages: 253-261
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mycobacterium tuberculosis H37Rv is capable of inhibiting necrosis of the infected macrophages via activation of caspase-9. (2007)
  • Author(s): Uchiyama R, Kawamura I, Kawanishi M, Tsuchiya K, Tominaga T, Kaku T, Fukasawa Y, Sakai S, Fujimura T, Nomura T, Mitsuyama M
  • Journal Title: Infect. Immun. 75:(in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Critical involvement of domain 4 of listeriolysin 0 and allied bacterial cytolysins in temperature-and pH-dependentloss of cytolytic activity. (2007)
  • Author(s): Nomura T, Kawamura I, Kohda C, Baba H, Ito Y, Kimoto T, Watanabe I, Mitsuyama M
  • Journal Title: Microbiology 153:(in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cytolysin-dependent endosomal escape is required but not sufficient for the induction of Th1 immune response against Listeria infection : A distinct role for listeriolysin 0 as determined by cytolysin gene replacement. (2007)
  • Author(s): Hara H, Kawamura I, Nomura T, Tominaga T, Mitsuyama M
  • Journal Title: Infect. Immun. accepted
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] RD1 region in mycobacterial genome is involved in induction of necrosis in the infected RAW264 cells via mitochondrial membrane damage and ATP depletion. (2007)
  • Author(s): Kaku T, Kawamura I, Uchiyama R, Kurenuma T, Mitsuyama M
  • Journal Title: FEMS Microbiol. Lett. accepted
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasin. (2007)
  • Author(s): Suzuki, T. et al.
  • Journal Title: J. Immunol. 177 Pages: 4709-4717
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] New animal model of shigellosis in the Guinea pig : its usefulness for protective efficacy studies (2007)
  • Author(s): Shim, D.H.et al.
  • Journal Title: J. Immunol. 178 Pages: 2476-2482
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dependence of the lethal effect of pore-forming cytolysins on the cytolytic activity. (2006)
  • Author(s): Watanabe I 他6名
  • Journal Title: J. Med. Microbiol. 55 Pages: 505-510
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Limited contribution of Toll-like receptor (TLR) 2 and TLR4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans. (2006)
  • Author(s): Nakamura K 他16名
  • Journal Title: FEMS Immunol. Med. Microbiol. 47 Pages: 148-154
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Modification of allergic inflammation in murine model of rhinitis by different bacterial ligands : Involvement of masct cells and dendritic cells. (2006)
  • Author(s): Yamamoto K 他3名
  • Journal Title: Clin. Exp. Allergy 36 Pages: 760-769
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Listeriolysin O derived from Listeria monocytogenes inhibits the effector phase of an experimental allergic rhinitis induced by ovalbumin in mice. (2006)
  • Author(s): Yamamoto K 他5名
  • Journal Title: Clin. Exp. Immunol. 144 Pages: 475-484
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Sustained-release vancomycin sheet may help to prevent prosthetic graft methicilin-resistant Staphylococcus aureus infection. (2006)
  • Author(s): Hirose K 他10名
  • Journal Title: J. Vasc. Surg. 44 Pages: 377-382
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Pathogen recognition and innate immunity. (2006)
  • Author(s): Akira S. et al.
  • Journal Title: Cell 124 Pages: 783-801
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Generation of measles virus with a segmented RNA genome (2006)
  • Author(s): Takeda M et al.
  • Journal Title: J. Virol. 80 Pages: 4242-4248
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Recombinant wild-type measles virus containing a single N481Y substitution in its haemagglutinin cannot use receptor CD46 as efficiently as that having the haemagglutinin of the Edmonston laboratory strain (2006)
  • Author(s): Seki et al.
  • Journal Title: J. Gen. Virol. 87 Pages: 1643-1648
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] OX40-OX40L interaction through T cell-T cell contact contributes to CD4 T cell longevity (2006)
  • Author(s): Pejman Soroosh
  • Journal Title: J. Immunol 176 Pages: 5975-5987
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Important role of endogenous Erythropoietin system to recruit endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice. (2006)
  • Author(s): 佐藤 公雄
  • Journal Title: Circulation 113 Pages: 1442-1450
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regulatory T cell-like activity of Foxp3^+ adult T-cell leukemia cells. (2006)
  • Author(s): 陳書明 (Shumign Chen)
  • Journal Title: Int. Immunol 18 Pages: 269-277
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] IL-15 regulates CD8^+ T cell contraction during primary infection (2006)
  • Author(s): Yajima T. et al.
  • Journal Title: J. Immunol. 176 Pages: 507-515
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The role of IL-15 in colitis induced by dextran sulphate sodium in mice. (2006)
  • Author(s): Yoshihira K., et al.
  • Journal Title: Gut 55 Pages: 334-341
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Toll-like receptors 2 and 4 are differentially involved in Fas-dependent apoptosis in Peyer's patch and liver at an early stage after bile duct ligation in mice. (2006)
  • Author(s): Ogawa A., et al.
  • Journal Title: Gut 55 Pages: 105-113
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Impaired protection against Mycobacterium bovis Bacillus Calmette-Guerin infection in IL-15 deficient mice (2006)
  • Author(s): Saito K., et al.
  • Journal Title: J. Immunol. 176 Pages: 2496-2504
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Interleukin-15 prevents allergic rhinitis though activation of antigen-specfic CD8^+ T cells. (2006)
  • Author(s): Aoi N., et al.
  • Journal Title: J. Allergy Clin. Immunol. 117 Pages: 1359-66.
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] MyD88-dependent signaling for IL-15 production is important for the development of CD8αα and TCRγσ intestinal intraepithelia T lymphocytes (2006)
  • Author(s): Yu Q., et al.
  • Journal Title: J. Immunol 177
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] An important role of Tyk2 in APC function of dendritic cells for priming CD8^+ T cells production IFN-γ (2006)
  • Author(s): Aizu K., et al.
  • Journal Title: Eur. J. Immunol. 36: Pages: 3060-3070
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regulatory roles of NKT cells in the induction and maintenance of cyclophosphamide-induced tolerance (2006)
  • Author(s): Iwai, T et al.
  • Journal Title: J. Immunol 176: Pages: 400-9
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Immunological protection against Mycobacterium tuberculosis infection (2006)
  • Author(s): Yoshikai Y.
  • Journal Title: Crit. Rev. Immunol. 26 Pages: 515-26.
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Crystallization and preliminary crystallographic analysis of orotidine 5'-monophosphate decarboxylase from human malaria parasite Plasmodium falciparum. (2006)
  • Author(s): Krungkrai S.R., Tokuoka K., Kusakari Y., Inoue T., Adachi H., Matsumura H., Takano K., Murakami S., Mori Y., Kai Y., Krungkrai J., Horii T.
  • Journal Title: Acta Crystallographica Secion F 62(Pt6) Pages: 542-545
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] High titers of IgG antibodies against Plasmodium falciparum Serine repeat antigen 5 (SERA5) are associated with protection against severe malaria in Ugandan children. (2006)
  • Author(s): Okech B, Mujuzi G, Ogwal A, Shirai H., Horii T, Egwang TG
  • Journal Title: Am. J. Trop. Med. Hyg. 74・2 Pages: 191-197
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] DNA vaccination of macaques by a full-genome SHIV plasmid that has an IL-2 gene and produces non-infectious virus particles (2006)
  • Author(s): Horiuchi, R., Akahata W., Kuwata T., Enose Y., Ido E., Suzuki, H., Miyake, A., Saito, N., Ibuki, K., Goto, T., Miura, T., Hayami, M.
  • Journal Title: Vaccine 24,17 Pages: 3677-3685
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Antimalarial Effect of Bis-pyridinum Salts, N, N'-Hexamethylenebis (4-carbamoyl-1-alkylpyridinium bromide). (2006)
  • Author(s): Fujimoto, K., Morisaki, D., Yoshida, M., Namba, T., Kim, H.-S., Wataya, Y., Kourai, H., Kakuta, H., Sasaki, K.
  • Journal Title: Bioorg. Med. Chem. Lett. In press
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Intracellular survival of Shigella. (2006)
  • Author(s): Ogawa, M., Sasakawa, C.
  • Journal Title: Cell. Microbiol 8 Pages: 177-184
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Bacterial evasion of the autophagic defense system. (2006)
  • Author(s): Ogawa, M., Sasakawa, C.
  • Journal Title: Curr. Opin. Microbiol. 9 Pages: 62-68
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] EspF of Enteropathogenic Escherichia coli Binds Sorting Nexin. (2006)
  • Author(s): Marches, O. et al.
  • Journal Title: J. Bacteriol. 9 Pages: 3110-3115
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Microtubule-Severing Activity of Shigella Is Privotal for Intercellular Spreading. (2006)
  • Author(s): Yoshida, S. et al.
  • Journal Title: Science 314 Pages: 985-989
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Shigella IpgB1 promotes bacterial entry through the FLMO-Dock180 machinery. (2006)
  • Author(s): Handa, Y. et al.
  • Journal Title: Nat. cell Biol 9 Pages: 121-128
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Receptor-independent infection of murine coronavirus : analysis by spinoculation. (2006)
  • Author(s): Watanabe R, Matsuyama S, Taguchi F
  • Journal Title: J. Virol. 80 Pages: 4901-4908
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] [Establishment and progress of Sendai virus engineering (2006)
  • Author(s): Nagai Y, Kato A, Inoue M.
  • Journal Title: tanpakushitsu Kakusan Koso 51(1) Pages: 27-37
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Pathogen recognition and innate immunity. Takeda M, Ohno S, Seki F, Hashimoto K, Miyajima N, Takeuchi (2006)
  • Author(s): Akira S. et al.
  • Journal Title: Cell 123 Pages: 783-801
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Generation of measles virus with a segmented RNA genome (2006)
  • Author(s): Takeda M, Nakatsu Y, Ohno S, Seki F, Tahara M, Hashiguchi T, Yanagi Y.
  • Journal Title: J Virol 80 Pages: 4242-4248
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Recombinant wild-type measles virus containing a single N481Y substitution in its haemagglutinin cannot use receptor CD46 as efficiently as that having the haemagglutinin of the Edmonston laboratory strain (2006)
  • Author(s): Seki F, Takeda M, Minagawa H, Yanagi Y.
  • Journal Title: J Gen Virol 87 Pages: 1643-1648
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] OX40-0X4OL interaction through T cell-T cell contact contributes to CD4 T cell longevity (2006)
  • Author(s): Soroosh P et al.
  • Journal Title: J. Immunol. 176 Pages: 5975-87
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Important role of endogenous Erythropoietin system to recruit endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice. (2006)
  • Author(s): Satoh K et al.
  • Journal Title: Circulation 113 Pages: 1442-50
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulatory T cell-like activity of Foxp3+ adult T-cell leukemia cells. (2006)
  • Author(s): Chen S, et al.
  • Journal Title: Int. Immunol. 18 Pages: 269-277
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] IL-15 regulates CD8+ T cell contraction during primary infection (2006)
  • Author(s): Yajima T., Yoshihara K., Nakazato K., Kumabe S., Koyasu S., Sad, S., Shen H., Kuwano H., Yoshikai
  • Journal Title: J. Immunol. 176 Pages: 507-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The role of IL-15 in colitis induced by dextran sulphate sodium in mice. (2006)
  • Author(s): Yoshihara K., Yajima T., Kubo C., Yoshikai Y.
  • Journal Title: Gut 55 Pages: 334-341
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Toll-like receptors 2 and 4 are differentially involved in Fas-dependent apoptosis in Peyer's patch and liver at an early stage after bile duct ligation in mice. (2006)
  • Author(s): Ogawa A., Tagawa T., Nishimura H., Yajima T., Abe T., Arai T., Taniguchi M., Takeda K., Akira S., Nimura Y., Yoshikai Y.
  • Journal Title: Gut 55 Pages: 105-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Impaired protection against Mycobacterium bovis Bacillus Calmette-Guerin Infection in IL-15 deficient mice (2006)
  • Author(s): Saito K., Yajima T., Kumabe S., Doi T., Sad S., Shen H., Yoshikai Y.
  • Journal Title: J. Immunol. 176 Pages: 2496-2501
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Interleukin-15 prevents allergic rhinitis though activation of antigen-specific CD8+ T cells. (2006)
  • Author(s): Aoi N., Masuda T., Murakami D., Yajima, T., Mizubuchi H., Kawauchi H., Yoshikai Y.
  • Journal Title: J. Allergy Clin. Immunol. 117 Pages: 1359-66
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] MyD88-dependent signaling for IL-15 production plays an important role in CD8aa TCRap and TCRyβ intestinal intraepithelial lymphocytes (2006)
  • Author(s): Yu Q., Tang C., Xun S., Yajima T., Takeda K., Yoshikai Y.
  • Journal Title: J. Immunol. 176 Pages: 6180-6185
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] An important role of Tyk2 in APC function of dendritic cells for priming CD8+ T cells producing IFN-y (2006)
  • Author(s): Aizu K., Li W., Yajima T., Arai T., Shimoda K., Nimura Y., Yoshikai Y.
  • Journal Title: Eur. J.Immunol. 36 Pages: 3060-3070
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulatory roles of NKT cells in the induction and maintenance of cyclophosphamide-induced tolerance (2006)
  • Author(s): Iwai, T., Tomita Y., Shimizu I., Yasunami Y., Kajiwara T., Okano S., Yoshikai Y., Taniguchi M., Nomoto K., Yasui H.
  • Journal Title: J. Immunol. 177 Pages: 8400-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Crystallization and preliminary crystallographic analysis of orotidine 5'-monophosphate decarboxylase from human malaria parasite Plasmodium falciparum. (2006)
  • Author(s): Krungkrai S.R., Tokuoka K., Kusakari Y., Inoue T., Adachi H., Matsumura H., Takano K., Murakami S., Mori Y., Kai Y., Krungkrai J., Horii T.
  • Journal Title: Acta Crystallographica Section F 62(Pt 6) Pages: 542-545
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] G High titers of IgG antibodies against Plasmodium falciparum serine repeat antigen 5 (SERA5) are associated with protection against severe malaria in Ugandan children. (2006)
  • Author(s): Okech, B., Mujuzi U, Ogawal A., Shirai, H., Horii T., Egwang, T.
  • Journal Title: Am. J. Trop. Med. Hyg. 74(2) Pages: 191-197
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 「研究成果報告書概要(欧文)」より (2006)
  • Author(s): Horiuchi, R., Akahata, W., Kuwata, T., Enose, Y., Ido, E., Suzuki, H., Miyake, A., Saito, N., Ibuki, K., Goto, T., Miura, T., Hayami, M.
  • Journal Title: Vaccine 24(17) Pages: 3677・3685
• [Journal Article] Antimalarial Effect of Bis-pyridinium Salts, N,N'-Hexamethylenebis (4-carbamoyl-1-alkylpyridinium bromide). (2006)
  • Author(s): Fujimoto, K., Morisaki, D., Yoshida, M., Namba, T., Kim, H.-S., Wataya, Y., Kourai, H., Kakuta, H., Sasaki, K.
  • Journal Title: Bioorg. Med. Chem. Left. 16 Pages: 2758-2760
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dependence of the lethal effect of pore-forming cytolysins on the cytolytic activity. (2006)
  • Author(s): Watanabe I, Nomura T, Tominaga T, Yamamoto K, Kohda C, Kawamura I, Mitsuyama M
  • Journal Title: J. Med. Microbiol. 55 Pages: 505-510
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Limited contribution of Toll-like receptor (TLR) 2 and TLR4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans. (2006)
  • Author(s): Nakamura K, Miyagi K, Koguchi Y, Kinjo Y, Uezu K, Kinjo T, Akamine M, Fujita J, Kawamura I, Mitsuyama M, Adachi Y, Ohno N, Takeda K, Akira S, Miyazato A, Kaku M, Kawakami K.
  • Journal Title: FEMS Immunol. Med. Microbiol. 47 Pages: 148-154
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Modification of allergic inflammation in murine model of rhinitis by different bacterial ligands Involvement of masct cells and dendritic cells. (2006)
  • Author(s): Yamamoto K, Kawamura I, Ito J, Mitsuyama M
  • Journal Title: Clin. Exp. Allergy 36 Pages: 760-769
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Listeriolysin 0 derived from Listeria monocytogenes inhibits the effector phase of an experimentalallergic rhinitis induced by ovalbumin in mice. (2006)
  • Author(s): Yamamoto K, Kawamura I, Tominaga T, Nomura T, Ito J, Mitsuyama M
  • Journal Title: Clin. Exp. Immunol. 144 Pages: 475-484
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sustained-release vancomycin sheet may help to prevent prosthetic graft methicillin-resistant Staphylococcus aureus infection. (2006)
  • Author(s): Hirose K, Marui A, Arai Y, Nomura T, Inoue S, Kaneda K, Kamitani T, Fujita M, Mitsuyarta M, Tabata Y, Komeda M
  • Journal Title: J.-Vasc. Surg. 44 Pages: 377-382
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Shigella Spa33 is an essential C-ring component of type III secretion machinery. (2006)
  • Author(s): Morita-Ishihara, T. et al.
  • Journal Title: J. Biol. Chem. 281 Pages: 599-607
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Intracellular survival of Shigella. (2006)
  • Author(s): Ogawa, M., Sasakawa, C.
  • Journal Title: Cell. Microbiol. 8 Pages: 177-184
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] EspF of Enteropathogenic Escherichia coli Binds Sorting Nexin. (2006)
  • Author(s): Marches, 0. et al.
  • Journal Title: J. Bacteriol. 188 Pages: 3110-3115
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Microtubule-Severing Activity of Shigella Is Pivotal for Intercellular Spreading. (2006)
  • Author(s): Yoshida, S. et al.
  • Journal Title: Science 314 Pages: 985-989
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Shigella IpgBl promotes bacterial entry through the ELMO-Dock180 machinery. (2006)
  • Author(s): Handa, Y. et al.
  • Journal Title: Nat. Cell Biol 9 Pages: 121-128
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Receptor independent infection of mouse hepatitis virus : analysis by spinoculation (2006)
  • Author(s): Watanabe R, Suzuki K, Taguchi F.
  • Journal Title: Advances of Experimental Medicine and Biology 581 Pages: 331-334
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Receptor-independent spread of a neurotropic murine coronavirus MHV-JHMV in mixed neural culture. (2006)
  • Author(s): Nakagaki K, Nakagaki K, Taguchi F.
  • Journal Title: Advances of Experimental Medicine and Biology 581 Pages: 327-330
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of ferret ACE2 and its recertor function for SARS-coronavirus vaccine (2006)
  • Author(s): Zamoto A, Taguchi F, Fukushi S, Morikawa S, Yamada YK.
  • Journal Title: Advances of Experimental Medicine and Biology 581 Pages: 519-522
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Highly attenuated vaccinia virus DIs as a potential SARS. (2006)
  • Author(s): Ishii K, Yokota Y, Takemori T, Hasegawa H, Mizutani T, Morikawa S, Taguchi F, Miyamura T.
  • Journal Title: Advances of Experimental Medicine and Biology 581 Pages: 593-596
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Matsuyama S and Taguchi F Receptor-independent infection of murine coronavirus : analysis by spinoculation. (2006)
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  • Journal Title: Journal of Virology. 80 Pages: 4901-4908
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Establishment and progress of Sendai virus engineering (2006)
  • Author(s): Nagai Y, Kato A, Inoue M.
  • Journal Title: Tanpakushitsu Kakusan Koso 51(1) Pages: 27-37
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhanced resistance to Gram-positive bacterium and increased susceptibility to bacterial endotoxin in mice sensitized with Propionibacterium. acnes : Involvement of Toll-like receptor. (2005)
  • Author(s): Mochizuki H 他3名
  • Journal Title: FEMS Immunol. Med. Microbiol. 43 Pages: 287-293
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Listeriolysin O-induced membrane permeation mediates persistent IL-6 production in Caco-2 cells during Listeria monocytogenes infection in vitro. (2005)
  • Author(s): Tsuchiya K 他5名
  • Journal Title: Infect. Immun. 73 Pages: 3869-3877
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Involvement of reactive oxygen intermediate in the enhanced expression of virulence-associated genes of Listeria monocytogenes inside activated macrophages. (2005)
  • Author(s): Makino M 他5名
  • Journal Title: Microbiol. Immunol. 49 Pages: 805-811
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Involvement of the virulence gene products of Yarsinia enterocolitica in the immune response of infected mice. (2005)
  • Author(s): Takeuchi O 他5名
  • Journal Title: FEMS Immunol. Med. Microbiol. 45 Pages: 321-329
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Streptomycin-dependent exhibition of cytokine -inducing activity in streptomycin-dependent Mycobacterium tuberculosis strain 18b. (2005)
  • Author(s): Fukasawa Y 他9名
  • Journal Title: Infect. Immun. 73 Pages: 7051-7055
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Listeriolysin O, a cytolysin derived fronm Listeria monocytogenes, inhibits generation of ovalbumin-specific Th2 immune response by skewing maturation of antigen-specific T cells int Th1 cells. (2005)
  • Author(s): Yamamoto K 他6名
  • Journal Title: Clin. Exp. Immunol. 142 Pages: 268-274
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Seeligeliolysin O, A protein toxin of Listeria seeligeri, stimulates macrophage cytokine production via toll-like receptors in a profile different from that induced by other bacterial ligands. (2005)
  • Author(s): Ito Y 他5名
  • Journal Title: Int. Immunol. 17 Pages: 1597-1606
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Aberrant activation of the interleukin-w autocrine loop through the nuclear factor of activated T cells by nonleukemogenic human T-cell leukemia virus type 2 but not by leukemogenic type 1 virus. (2005)
  • Author(s): Nimura, A
  • Journal Title: J. Virol. 79 Pages: 11925-34
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8^+ memory T cells and their capacity for secondary expansion. (2005)
  • Author(s): Hendriks, J
  • Journal Title: J. Immunol 175 Pages: 1665-1676
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Positional identification of TNFSF4, encoding OX40 ligandm, as a gene that influences atherosclerosis susceptibility. (2005)
  • Author(s): Wang X
  • Journal Title: Nature Genet 37 Pages: 365-372
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. (2005)
  • Author(s): Shiratori I.
  • Journal Title: J Immunol. 175 Pages: 4441-4449
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] In vivo IL-10 gene delivery suppresses airway eosinophilia and hyperreactivity by down-regulating APC functions and migration without impairing the antigen-specifisystemic immune response in a mouse model of allergic airway inflammmation. (2005)
  • Author(s): Nakagome K.
  • Journal Title: J Immunol. 174 Pages: 6955-6966
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Angiotensin receptor blockers suppress antigen-specific T cell responses and ameliorate collagen-induced arthritis in mice. (2005)
  • Author(s): Segawa K.
  • Journal Title: Arthritis Rheum. 52 Pages: 1920-1928
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Downregulation of IL-12 and a novel negative feedback system mediated by CD25+ CD4+ T cells. (2005)
  • Author(s): Sato K.
  • Journal Title: Biochem Biophys Res Commun. 330 Pages: 226-232
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Plasmodium falciparum serine-repeat antigen (SERA) forms a homodimer through disulfide bond. (2005)
  • Author(s): Sato D., Li J., Mitamura T., Horii T
  • Journal Title: Parasitol. Int. 54・4 Pages: 261-265
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A Novel Enzyme complex of orotate Phasphoribosyltransferase and orotidine 5'-monophosphate decarboxylase in human malaria parasite Plasmodium falciparum : physical association, kinetics and inhibition characterization. (2005)
  • Author(s): Krungkrai S, DelFraino BJ, Smiley JA, Prapunwattana P, Mitamura T, Horii T
  • Journal Title: Biochemistry 44・5 Pages: 1643-1652
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Priming-boosting vaccination with recombinant Mycobacterium bovis bacillus Calmette-Guerin and a nonreplication vaccinia virus recombinant leads to long-lasting and effective immunity. (2005)
  • Author(s): Ami, Y.
  • Journal Title: J Virol 79巻 Pages: 12871-12879
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mycobacterial codon optimization enhances antigen expression and virus-specific immune responses in recombinant Mycobacterium bovis bacille Calmette-Guerin expressing human immunodeficiency virus type 1 Gag. (2005)
  • Author(s): Kanekiyo, M.
  • Journal Title: J Virol 79巻 Pages: 8716-8723
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of the specific amino acid sequence of the membrane-spanning domain of human immunodeficiency virus type 1 in membrane fusion. (2005)
  • Author(s): Miyauchi, K.
  • Journal Title: J Virol 79巻 Pages: 4720-4729
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Influence of Glycosylation on the Efficacy of an Env-Based Vaccine against Simian Immunodeficiency Firus SIV mac239 in a Macaque AIDS Model. (2005)
  • Author(s): Mori, K.
  • Journal Title: J Virol 79巻 Pages: 10386-10396
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD20-transformed rat fibroblasts. (2005)
  • Author(s): Nonaka, M.
  • Journal Title: Oncogene 24巻24号 Pages: 3976-3986
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A20 is a negative regulator of IFN regulatory factor 3 signaling. (2005)
  • Author(s): Saitoh, T.
  • Journal Title: J Immunol 174巻 Pages: 1507-1512
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Vaccination of Rhesus Macaques with Recombinant Mycobacterium bovis Bacillus Calmette-Guerin Env V3 Elicits Neutralizing Antibody-Mediated Protection against Simian-Human Immunodeficiency Virus with a Homologous but Not a Heterologous V3 Motif. (2005)
  • Author(s): Someya, K.
  • Journal Title: J Virol 79巻 Pages: 1452-1462
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification of novel low molecular weight CXCR4 antagonisis by structural tuning of cyclic tetrapeptide scaffolds. (2005)
  • Author(s): Tamamura, H.
  • Journal Title: J Med Chem 48巻 Pages: 3280-3289
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. (2005)
  • Author(s): Tamamura, H.
  • Journal Title: J Med Chem 48巻 Pages: 380-391
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synthesis and evaluation of β-carbolinium cations as new antimalarial agents based on pi-delocalized lipophilic cation (DLC) hypothesis. (2005)
  • Author(s): Takasu, K., Shimogama, T., Saiin, C, Kim, H.-S, Wataya, Y, Brun, R, Ihara, M.
  • Journal Title: Chem. Pharm. Bull. 53(6) Pages: 653-661
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Co-catalyzed autoxidation of alkene in the presence of silane. The effect of the structure of silanes on the efficiency of the reaction and on the product distribution. (2005)
  • Author(s): Wu, J.-M., Kunikawa, S., Tokuyasu, T., Masuyama, A., Nojima, M., Kim, H.-S., Wataya, Y.
  • Journal Title: Tetrahedron, 61 Pages: 9961-9968
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synthesis and biological activity of fatty acid conjugate of quinine. (2005)
  • Author(s): Kumura, N., Izumi, M., Nakajima, S., Shimizu, S., Kim, H.-S., Wataya, Y., Baba, N.
  • Journal Title: Biosci. Biotech. Biochem. 69(11) Pages: 2250-2253
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synthesis of novel siRNAs having thymidine dimers consisting of a carbamate or an urea linkage at their 3' overhang regions and their ability to suppress human RNase L protein expression. (2005)
  • Author(s): Ueno, Y., Naito, T., Kawada, K., Shibata, A., Kim, H.-S., Wataya, Y., Kitade, Y.
  • Journal Title: Biol. Biophy. Res. Comm., 20, 330(4) Pages: 1168-1175
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synthesis of 5'-methylenearisteromycin and its 2-fluoro congener with potent antimalarial activity due to the parasite S-adensosyl homocysteine hydrolase Inhibition. (2005)
  • Author(s): Takagi, T., Sukeda, M., Kim, H.-S., Wataya, Y., Kitade, Y., Matsuda, A., Shuto, S.
  • Journal Title: Org. Biomol. Chem., 3 Pages: 1245-1251
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 1,2,4,5-Tetraoxan cycloalkanes : Synthesis and Antimalarial Activity. (2005)
  • Author(s): Masuyama, A., Wu, J-M., Nojima, M., Kim, H.-S., Wataya, Y.
  • Journal Title: Mini-Reviews Med. chem. 5 Pages: 1035-1043
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Sequence analysis of the 5'-flanking regions of human dihydoropyrimidine dehydrogenase gene : Identification of a new polymorphism related with effects of 5-fluorouracil. (2005)
  • Author(s): Hasegawa, T., Kim, H.-S., Fukushima, M., Wataya, Y.
  • Journal Title: Nucleosides Nucleotides Nucleic Acids, 24(4) Pages: 233-242
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Inhibitory Mechanisms of 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)uracil (EUrd) on RNA Synthesis. (2005)
  • Author(s): Yokogawa, T., Kanda, H., Takatori, S., Takenaka, K., Naito, T., Sasaki, T., Matsuda, A., Fukushima, M., Kim, H.-S., Wataya, Y.I
  • Journal Title: Nucleosides Nucleotides Nucleic Acids, 24(3) Pages: 227-232
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Protease-mediated enhancement of SARS coronavirus infection. (2005)
  • Author(s): Matsuyama S, Ujike M, Morikawa S, Tashiro M, Taguchi F.
  • Journal Title: Proc. Natl. Acad. Sci., U.S.A. 102 Pages: 12543-12547
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Vesicular stomatitis virus pseudotyped with sevire acute respiratory syndrome coronavirus spike protein. (2005)
  • Author(s): Fukushi S, Mizutani T, Saijo M, Matsuyama S, Miyajima N, Taguchi F, et al.
  • Journal Title: J Gen Virol 86 Pages: 2269-2274
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Receptor-independent spread of a highly neurotropic murine coronavirus JHMV from initially infected microglial cells in mixed neural culture. (2005)
  • Author(s): Nakagaki K, Nakagaki K, Taguchi F
  • Journal Title: J. Viol. 79 Pages: 6102-6110
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Receptor-independent spread of a highly neurotropic murine coronavirus JHMV from initially infected microglia cells in mixed neural culture. (2005)
  • Author(s): Nakagaki K, Nakagaki K, Taguchi F
  • Journal Title: J. Virol 79 Pages: 6102-6110
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Escape of intracellular Shigella from autophagy. (2005)
  • Author(s): Ogawa M, Yoshimori T, Suzuki T, Sagara H, Mizushima N, Sasakawa C
  • Journal Title: Science 307(5710) Pages: 727-731
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Involvement of the roll-like receptor 9 signaling pathway in the induction of innate immunity by baculovirus. (2005)
  • Author(s): Abe T, Hemmi H, Moriishi K, Tamura S, Takaku H, Akira S, Matsuura Y
  • Journal Title: J. Virol. 79(5) Pages: 2847-1858
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Listeriolysin O-induced membrane permeation mediates persistent IL-6 production in Caco-2 cells during Listeria monocytogenes infection in vitro. (2005)
  • Author(s): Tsuchiya K, Kawamura I, Takahashi A, Nomura T, Kohda C, Mitsuyama M
  • Journal Title: Infect Immun. 73(7) Pages: 3869-3877
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nonredundant roles of Sema4A in the immune system : defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice. (2005)
  • Author(s): Kumanogoh A, Shikina T, Suzuki K, Uematsu S, Yukawa K, Kashiwamura S, Tsutsui H, Yamamoto M, Takamatsu H, Ko-Mitamura EP, Takegahara N, Marukawa S, Ishida I, Morishita H, Prasad DV, Tamura M, Mizui M, Toyofuku T, Akira S, Takeda K, Okabe M, Kikutani
  • Journal Title: Immunity 22(3) Pages: 305-16
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. (2005)
  • Author(s): Kochi Y, Yamada R, Suzuki A, Harley JB, Shirasawa S, Sawada T, Bae SC, Tokuhiro S, Cjang X, Sekine A, Takahashi A, Tsunoda T, Ohnishi Y, Kanfman KM, Kang CP, Kang C, Otsubo S, Yumura W, Mimori A, Koike T, Nakamura Y, Sasazuki T, Yamamoto K
  • Journal Title: Nat Genet. 37(5) Erratum:37(6) Pages: 478-485, Erantum:652
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The development of vaccines against SARS corona virus in mice and SCID-PBL/humice. (2005)
  • Author(s): Okada M, Takemoto Y, Okuno Y, Hashimoto S, Yoshida S, Fukunaga Y, Tanaka T, Kita Y, Kuwayama S, Muraki Y, Kanamaru N, Takai H, Okada C, Sakaguchi Y, Furukawa I, Yamada K, Matsumoto M, Kase T, deMello DE穂h氏PeirisJSM, Chen P.J, Yamamoto N, Yashimaka Y, Nomura T, Ishida I, Morikawa S, Tashiro M, Sakatani M
  • Journal Title: Vaccine 23(17-18): Pages: 2269-2272
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor gamma-chain knocked-out AIDS mouse model. (2005)
  • Author(s): Nakata H, Maeda K, Miyakawa T, Shibayama S, Matsuo M, Takaoka Y, Ito M, Kayanagi Y, Mitsuya H
  • Journal Title: J. Virol. 79(4) Pages: 2087-2096
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Influence of glycosylation on the efficacy of an Env-based vaccine against simian immunodeficiency virus SIVmac239 in a macaque AIDS model. (2005)
  • Author(s): Mori K, Sugimoto C, Ohgimoto S, Nakayama EE, Shioda T, Kusagawa S, Takebe Y, Kano M, Matano T, Yuasa T, Kitaguchi D, Miyazawa M, Takahashi Y, Yasunami M, Kimura A, Yamamoto N, Suzuki Y, Nagai Y
  • Journal Title: J. Virol. 79(16) Pages: 10386-10396
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] AIPI/Alix is a binding partner of Sendai virus C protein and facilitates virus budding. (2005)
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• [Journal Article] A novel autoregulatory mechanism for transcriptional adtivation of IL-15 gene by non-secretable Isoform of IL-15 generated by alternative splicing. (2005)
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• [Journal Article] Critical role of IL-15 in early activation of memory CD8+ CTL after re-infection. (2005)
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• [Journal Article] IPS-1, an adaptor triggering RIG-I-and Mda5-mediated type I interferon induction (2005)
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• [Journal Article] Long untranslated regions of the measles virus M and F genes control virus replication and cytopathogenicity (2005)
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• [Journal Article] Contributions of matrix and large protein genes of the measles virus edmonston strain to growth in cultured cells as revealed by recombinant viruses (2005)
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• [Journal Article] In vivo IL-10 gene delivery suppresses airway eosinophilia and hyperreactivity by down-regulating APC functions and migration without impairing the antigen-specific systemic immune response in a mouse model of allergic airway inflammationl. (2005)
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• [Journal Article] A Novel Enzyme complex of orotate Phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase in human malaria parasite Plasmodium falciparum : physical association, kinetics and inhibition characterization. (2005)
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• [Journal Article] Priming-boosting vaccination with recombinant Mycobacterium bovis bacillus Calmette-Guerin and a nonreplicating vaccinia virus recombinant leads to long-lasting and effective immunity. (2005)
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• [Journal Article] Mycobacterial codon optimization enhances antigen expression and virus-specific immune responses in recombinant Mycobacterium bovis bacille Calmette-Guerin expressing human immunodeficiency virus type 1 Gag. (2005)
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• [Journal Article] Influence of Glycosylation on the Efficacy of an Env-Based Vaccine against Simian Immunodeficiency Virus SIVmac239 in a Macaque AIDS Model. (2005)
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• [Journal Article] Vaccination of Rhesus Macaques with Recombinant Mycobacterium bovis Bacillus Calmette-Guerin Env V3 Elicits Neutralizing Antibody-Mediated Protection against Simian-Human Immunodeficiency Virus with a Homologous but Not a Heterologous V3 Motif. (2005)
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• [Journal Article] Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the. CXCR4 antagonist FC131. (2005)
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• [Journal Article] Co-catalyzed autoxidation of alkene in the presence of silane. The effect of the structure of silanes on the efficiency of the reaction and on the product distribution. (2005)
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• [Journal Article] Enhanced Resistance to Gram-positive bacterium and increased susceptibility4 to bacterial endotoxin in mice sensitized with Propionibacterium. acnes : Involvement of Toll-like receptor. (2005)
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• [Journal Article] Listeriolysin 0-induced membrane permeation mediates persistent IL-6 production in Caco-2 cells during Listeria monocytogenes infection in vitro. (2005)
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• [Journal Article] Involvement of reactive oxygen intermediate in the enhanced expression of virulence-associated genes of Listeria monocytogenes inside activated macrophages. (2005)
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• [Journal Article] Involvement of the virulence gene products of Yersinia enterocolitica in the immune response of infected mice. (2005)
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• [Journal Article] Listeriolysin 0, a cytolysin derived from Listeria monocytogenes, inhibits generation of ovalbumin-specific Th2 immune response by skewing maturation of antigen-specific T cells into Th1 cells (2005)
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• [Journal Article] Seeligeliolysin 0, a protein toxin of Listeria seeligeri, stimulates macrophage cytokine production via toll-like receptors in a profile different from that induced by other bacterial ligands. (2005)
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• [Journal Article] Listeriolysin 0-induced membrane permeation mediates persistent IL-6 production in Caco-2 cells during Listeria monocytogenes infection in vitro. (2005)
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• [Journal Article] A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. (2005)
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• [Journal Article] The development of vaccines against SARS corona virus in mice and SCID-PBL/hu mice. (2005)
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• [Journal Article] Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/0N04128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor gamma-chain knocked-out AIDS mouse model. (2005)
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• [Journal Article] Influence of glycosylation on the efficacy of an Env-based vaccine against simian immunodeficiency virus SIVmac239 in a macaque AIDS model (2005)
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• [Journal Article] AIP1/Alix is a binding partner of Sendai virus C protein and facilitates virus budding. (2005)
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• [Journal Article] Listeriolysin 0-induced membrane permeation mediates persistent IL-6 production in Caco-2 cells during Listeria monocytogenes infection in vitro. (2005)
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• [Journal Article] A novel autoregulatory mechanism for transcriptional activation of IL-15 gene by non-secretable Isoform of IL-15 generated by alternative splicing. (2005)
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• [Journal Article] Critical role of IL-15 in early activation of memory CD8+ CTL after re-infection. (2005)
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• [Journal Article] The RNA helicase, RIG-I, plays an essential role for double-stranded RNA-induced innate antiviral responses. (2004)
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• [Journal Article] The roles of rwo IkB kinase-related kinases in lipopolyusaccharide and double stranded RNA signaling and viral infection. (2004)
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  • Journal Title: Nat. Immunol. 5(10) Pages: 1061-1068
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Human Malaria Parasite Orotate Phosphoribosyltransferase : Functional Expression, Characterizartion of Peaction Kinetic Mechanism and Inhibition Profile. (2004)
  • Author(s): Krungkrai, S., Aoki, S., Palacpac, N.M.Q., Sato, D., Mitamura, T., Krungrai, J., Horii, T.
  • Journal Title: Mol Biochem. Parasitol 134(2) Pages: 234-255
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Resistant influenza A viruses in children treated with oseltamivir : descriptive study. (2004)
  • Author(s): Kiso M., Mitamura K., Sakai-Tagawa Y, Shiraishi K, Kawakami C, Kimura K, Hayden FG, Sugaya N, Kawaoka Y
  • Journal Title: Lancet 364(9636) Pages: 759-765
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Enchanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus. (2004)
  • Author(s): Kobasa D, Takada A, Shinya K, Hatta M, Halfmann P, Theriault S, Suzuki H, Nishimura H, Mitamura K, Sugaya N, Usui T, Murata T, Maeda Y, Watanabe S, Suresh M, Suzuki T, Suzuki Y, Feldmann H, Kawaoka Y
  • Journal Title: Nature 431(7009) Pages: 703-707
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• [Journal Article] Human parvovirus B19 nonstructural protein transactivates the p21/WAF1 through Sp1. (2004)
  • Author(s): Nakajima, A., Morita, E., Saito, S., Sugamura, K.
  • Journal Title: Virology 329(2) Pages: 493-504
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• [Journal Article] Essential role of OX40L on B cells in persistent alloantibody production following repeated alloimmunnization. (2004)
  • Author(s): Kato, H., Kojima, H., Ishii, N., Hase, H., Imai, Y., Fujibayashi, T., Sugamura, K., Kobata, T.
  • Journal Title: J. Clin. Immunol. 24(3) Pages: 237-248
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• [Journal Article] Inhibiting the arp2/3 complex limits infection of both intracellular mature vaccinia virus and primate lentiviruses. (2004)
  • Author(s): Komano J, Miyauchi K, Matsuda Z, Yamamoto N.
  • Journal Title: Mol Biol Cell. 15(12) Pages: 5197-207
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• [Journal Article] Apoptosis induced by the histone deacetylase inhibitor FR901228 in human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells. (2004)
  • Author(s): N.Mori, T.Matsuda, M.Tadano, T.Kinjo, Y.Yamada, K.Tsukasaki, S.Ikeda, Y.Yamasaki, Y.Tanaka, T.Ohta, T.Iwamasa, M.Tomonaga, N.Yamamoto
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• [Journal Article] Expression of IL-6 and TNF-α in human alveolar epithelial cells is induced by invading, but not by adhering, Legionella pneumopjhila. (2004)
  • Author(s): Bin Chang, J.Amemura-Maekawa, F.Kura, I.Kawamura, M.Mirsuyama, H.Watanabe
  • Journal Title: Microbial Pathogenesis 37(6) Pages: 295-302
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• [Journal Article] Dissection of measles virus V protein in relation to its ability to block alpha/beta interferon signal transduction. (2004)
  • Author(s): Ohno S, Ono N, Takeda M, Takeuchi K, Yanagi Y.
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• [Journal Article] Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase Fyn T in TH2 cytokine regulation. (2004)
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• [Journal Article] Nucleosome-specific regulatory T cells engineered by triple gene transfer suppress a systemic autoimmune disease. (2004)
  • Author(s): Fujio K, Okamoto A, Tahara H, Abe M, Jiang Y, Kirtamura T, Hierose S, Yamamoto K.
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• [Journal Article] Transendothelial migration of human basophjils. (2004)
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• [Journal Article] Protective effects of nef-deleted SHIV or that having IFN-γ against disease induced with a pathogenic virus early after vaccination. (2004)
  • Author(s): Enose, Y., Kita, M., Yamamoto, T., Takahashi, E., Sakai, K., Shinohara, K., Hayami, M.
  • Journal Title: Arch. Virol. 149(9) Pages: 1705-1720
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• [Journal Article] Accessory genes of the paramyxoviridae, a large family of nonsegmented negative-strand RNA viruses, as focus of active investigation by reverse genetics. (2004)
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  • Journal Title: Curr Top Microbial Immunol 283 Pages: 197-248
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• [Journal Article] Cytotoxic T Lymphocyte-based Control of Simian Immunodeficiency Virus Replication in a Preclinical AIDS Vaccine Trial. (2004)
  • Author(s): Matano T, Kobayashi M, Igarashi H, Takeda A, Nakamura H, Kano M, Sugimoto C, Mori K, Iida A, Hirata T, Hasegawa M, Yuasa T, Miyazawa M, Takahashi Y, Yasunami M, Kimura A, O'Connor DH, Watkins DI, Nagai Y.
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• [Journal Article] Accessory genes of the Paramyxoviridae, a large family of nonsegmented negative-strand RNA viruses, as a focus of active investigation by reverse genetics. (2004)
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  • Journal Title: Curr. Top. Microbiol. Immunol. 283 Pages: 198-248
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• [Journal Article] Human Malaria Parasite Orotate Phosphoribosyltransferase : Functional Expression, Characterization of Reaction Kinetic Mechanism and Inhibition Profile. (2004)
  • Author(s): Krungkrai, S., Aoki, S., Palacpac, N.M.Q., Sato, D., Mitsumura, T., Krungkrai, J., Horii, T.
  • Journal Title: Mol. Biochem. Parasitol. 134(2) Pages: 245-255
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• [Journal Article] The RNA helicase, RIG-I,plays an essential role for double-stranded RNA-induced innate antiviral responses. (2004)
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  • Journal Title: Nat. Immunol. 5(7) Pages: 730-737
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• [Journal Article] The roles of two IkB kinase-related kinases in lipopolyusaccharide and double stranded RNA signaling and viral infection. (2004)
  • Author(s): Hemmi, H., Takeuchi, 0., Sato, S., Yamamoto, M., Kaisho, T., Sanjo, H., Kawai, T., Hoshino, K., Takeda, K., Akira S.
  • Journal Title: J. Exp. Med. 199 (12) Pages: 1641-1650
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• [Journal Article] Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkBzeta. (2004)
  • Author(s): Yamamoto, M., Yamazaki, S., Uematsu, S., Sato, S., Henimi, H., Hoshino, K., Kaisho, T., Kuwata, H., Takeuchi, 0., Takeshige, K., Saitoh, T., Yamaoka, S., Yamamoto N., Yamamoto, S., Muta, T., Takeda, K., Akira S.
  • Journal Title: Nature 430 (6996) Pages: 218-222
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Interferon-a induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 (2004)
  • Author(s): Kawai, T., Sato, S., Ishii, K.J., Coban, C., Hemmi, H., Yamamoto, M., Terai, K., Matsuda, M., Inoue, J., Uematsu, S., Takeuchi, 0., Akira S.
  • Journal Title: Nat. Immunol. 5 (10) Pages: 1061-1068
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Resistant influenza A viruses in children treated with oseltamivir : descriptivestudy. (2004)
  • Author(s): Kiso M, Mitamura K, Sakai-Tagawa Y, Shiraishi K, Kawakami C, Kimura K, Hayden FG, Sugaya N, Kawaoka Y.
  • Journal Title: Lancet 364 (9436) Pages: 759-765
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus. (2004)
  • Author(s): Kobasa D, Takada A, Shinya K, Hatta M, Halfmann P, Theriault S, Suzuki H, Nishimura H, Mitamura K, Sugaya N, Usui T, Murata T, Maeda Y, Watanabe S, Suresh M, Suzuki T, Suzuki Y, Feldmann H, Kawaoka Y.
  • Journal Title: Nature 431 (7009) Pages: 703-707
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human parvovirus B19 nonstructural protein transactivates the p21/WAF1 through Spl. (2004)
  • Author(s): Nakajima, A., Morita, E., Saito, S., Sugamura K.
  • Journal Title: Virology 329 (2) Pages: 493-504
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• [Journal Article] Essential role of OX4OL on B cells in persistent alloantibody production following repeated alloimmunnization. (2004)
  • Author(s): Kato, H., Kojima, H., Ishii, N., Hase, H., Imai, Y., Fujibayashi, T., Sugamura K., Kobata, T.
  • Journal Title: 1. Clin. Immunol. 24 (3) Pages: 237-248
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibiting the arp2/3 complex limits infection of both intracellulai mature vaccinia virus and primate lentiviruses. (2004)
  • Author(s): Komano J, Miyauchi K, Matsuda Z, Yamamoto N.
  • Journal Title: Vol Biol Cell. 15 (12) Pages: 5197-207
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• [Journal Article] Apoptosis induced by the histone deacetylase inhibitor FR901228 in human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells. (2004)
  • Author(s): N.Mori, T.Matsuda, M.Tadano, T.Kinjo, Y.Yamada, K.Tsukasaki, S.Ikeda, Y.Yamasaki, Y.Tanaka, T.Ohta, T.Iwamasa, M.Tomonaga, N.Yamamoto
  • Journal Title: 1 Virol. 78 (9) Pages: 4582-4590
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• [Journal Article] Expression of IL-6 and TNF-a in human alveolar epithelial cells is induced by invading, but not by adhering, Legionella pneumophila. (2004)
  • Author(s): Bin Chang, J.Amemura-Maekawa, F.Kura, I.Kawamura, M.Mitsuyama, H.Watanabe
  • Journal Title: Microbial Pathogenesis 37 (6) Pages: 295-302
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dissection of measles virus V protein in relation to its ability to block alpha/beta interferon signal transduction. (2004)
  • Author(s): Ohno S, Ono N, Takeda M, Takeuchi K, Yanagi Y.
  • Journal Title: Journal of General Virology 85 (10) Pages: 2991-2999
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in TH2 cytokine regulation. (2004)
  • Author(s): Davidson D, Shi X, Zhang S, Wang H, Nemer M, Ono N, Ohno S, Yanagi Y, Veillette A.
  • Journal Title: Immunity 21 (5) Pages: 707-717
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nucleosome-specific regulatory T cells engineered by triple gene transfer suppress a systemic autoimmune disease. (2004)
  • Author(s): Fujio K, Okamoto A, Tahara H, Abe M, Jiang Y, Kitamura T, Hirose S, Yamamoto K.
  • Journal Title: J Immunol 173 (3) Pages: 2118-2125
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transendothelial migration of human basophils. (2004)
  • Author(s): Iikura M, Ebisawa M, Yamaguchi M, Tachimoto H, Ohta K, Yamamoto K, Hirai K.
  • Journal Title: J Immunol 173 (8) Pages: 5189-5195
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protective effects of nef-deleted SHIV or that having IFN-7 against disease induced with a pathogenic virus early after vaccination. (2004)
  • Author(s): Enose, Y., Kita, M., Yamamoto, T., Takahashi, E.Sakai, K., Shinohara, K., Miura, T., Hayami,M.
  • Journal Title: Arch.ViroL 149 (9) Pages: 1705-1720
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• [Journal Article] Cytotoxic T Lymphocyte-based Control of Simian Immunodeficiency Virus Replication in a Preclinical AIDS Vaccine Trial. (2004)
  • Author(s): Matano T, Kobayashi M, Igarashi H, Takeda A, Nakamura H, Kano M, Sugimoto C, Mori K, Iida A, Hirata T, Hasegawa M, Yuasa T, Miyazawa M, Takahashi Y, Yasunami M, Kimura A, O'Connor DH, Watkins DI, Nagai Y.
  • Journal Title: J Exp Med 199 (12) Pages: 1709-1718
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• [Journal Article] Accessory genes of the Paramyxoviridae, a large family of nonsegmented negative-strand RNA viruses, as a focus of active investigation by reverese genetics. (2004)
  • Author(s): Nagai Y., Kato A.
  • Journal Title: Curr. Top. MicrobioL Immunol. 283 Pages: 198-248
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• [Journal Article] Human Malaria Parasite Orotate Phosphoribosyltransferase:Functional Expression, Characterization of Reaction Kinetic Mechanism and Inhibition Profile. (2004)
  • Author(s): Krungkrai, S., Aoki, S., Palacpac, N.M.Q., Sato, D., Mitamura, T., Krungkrai, J., Horii T.
  • Journal Title: Mol Biochem. Parasitol. 134(2) Pages: 245-255
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• [Journal Article] Peotective efficacy of an AIDS vaccine, a single DNA priming followed by a single booster with a recombinant replication-defective Sendai virus vector, in a macaque AIDS model. (2003)
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  • Journal Title: J Virol. 77(17) Pages: 9710-9715
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• [Journal Article] Role of adaptor TRIF in the MyD88-independent roll-like receptor signaling pathway. (2003)
  • Author(s): Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S
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• [Journal Article] TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. (2003)
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• [Journal Article] Toll-like receptors. (2003)
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• [Journal Article] Efficient isolation of wild strains of canine distemper virus in Vero cells expressing canine SLAM (CD150) and their adaptability to marmoset B95a cells. (2003)
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• [Journal Article] Histidine at position 61 and its adjacent amino acid residues are critical for the ability of SLAM (CD150) to act as a cellular receptor for measles virus. (2003)
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• [Journal Article] Comparative histopathological studies in the early stages of acute pathogenic and nanpathogenic SHIV-infected lymphoid organs. (2003)
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• [Journal Article] Construction and in vivo infection of a new simian/human immunodeficiency virus chimera containing the reverse transcriptase gene and the 3' half of the genomic region of human immunodeficiency virus type 1. (2003)
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• [Journal Article] Differences in gamma interferon production induced by listeriolysin O and ivanolysin O result in different levels of protective immunity in mice infected with Listeria monocytogenes and Listeria ivanovii. (2003)
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• [Journal Article] Seeligeriolysin O, a cholesterol-dependent cytolysin of Listeria seeligeri, induces gamma interferon from spleen cells of mice. (2003)
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• [Journal Article] Seeligeriolysin O, a cholesterol-dependent cytolysin of Listeria seeligeri, induces gamma interferon from spleen cells of mice. (2003)
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• [Journal Article] Impaired neutrophil maturation in truncated murine G-CSF receptor-transgenic mice. (2003)
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• [Journal Article] Differences in gamma interferon production induced by listeriolysin O and ivanolysin O result in different levels of protective immunity in mice infected with Listeria monocytogenes and Listeria ivanovii. (2003)
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• [Journal Article] OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses. (2003)
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• [Journal Article] Overexpression of interleukin-15 protects against Escherichia coli-induced shock accompanied by inhibition of tumor necrosis factor-alpha-induced apoptosis. (2003)
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• [Journal Article] JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation. (2003)
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• [Journal Article] Interleukin-154 as an immune adjuvant to increase the efficacy of Mycobacterium bovis bacillus Calmette-Guerin vassination. (2003)
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• [Journal Article] A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity. (2003)
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• [Journal Article] Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/gammac(null) mice : suppression by an inhibitor against NF-kappaB. (2003)
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• [Journal Article] Protective efficacy of an AIDS vaccine, a single DNA primingfollowed by a single booster with a recombinant replication-defective Sendai virus vector, in a macaque AIDS model. (2003)
  • Author(s): Takeda A, Igarashi H, Nakamura H, Kano M, Iida A, Hirata T, Hasegawa M, Nagai Y, Matano T.
  • Journal Title: J Virol. 77(17) Pages: 9710-9715
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• [Journal Article] Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. (2003)
  • Author(s): Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi 0, Sugiyama M, Okabe M, Takeda K, Akira S.
  • Journal Title: Science 301(5633) Pages: 640-643
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. (2003)
  • Author(s): Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi 0, Takeda K, AkiraS.
  • Journal Title: Nat Immunol. 4(11) Pages: 1144-50
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Toll-like receptors. (2003)
  • Author(s): Takeda K, Kaisho T, AkiraS.
  • Journal Title: Anna Rev Immunol. 21 Pages: 335-376
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Efficient isolation of wild strains of canine distemper virus in Vero cells expressing canine SLAM (CD150) and their adaptability to marmoset B95a cells. (2003)
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• [Journal Article] Histidine at position 61 and its adjacent amino acid residues are critical for the ability of SLAM (CD150) to act as a cellular receptor for measles virus. (2003)
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• [Journal Article] Comparative histopathological studies in the early stages of acute pathogenic and nonpathogenic SHIV-infected lymphoid organs. (2003)
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  • Journal Title: Virology 306(2) Pages: 334-346
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• [Journal Article] Construction and in vivo infection of a new simian/human immunodeficiency virus chimera containing the reverse transcriptase gene and the 3' half of the genomic region of human immunodeficiency virus type 1. (2003)
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• [Journal Article] Differences in gamma interferon production induced by listeriolysin 0 and ivanolysin 0 result in different levels of protective immunity in mice infected with Listeria monocytogenes and Listeria ivanovii. (2003)
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• [Journal Article] Seeligeriolysin 0, a cholesterol-dependent cytolysin of Listeria seeligeri, induces gamma interferon from spleen cells of mice. (2003)
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• [Journal Article] Overexpression of interleukin-15 protects against Escherichia co/i-induced shock accompanied by inhibition of tumor necrosis factor-alpha-induced apoptosis. (2003)
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• [Journal Article] JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation (2003)
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• [Journal Article] Interleukin-15 as an immune adjuvant to increase the efficacy of Mycobacterium bovis bacillus Calmette-Guerin vaccination. (2003)
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• [Journal Article] A duodenally absorbable CXC chemokine receptor 4 antagonist,KRH-1636, exhibits a potent and selective anti-HIV-1 activity. (2003)
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• [Journal Article] Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/gammac(null) mice: suppression by an inhibitor against NF-kappaB. (2003)
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• [Journal Article] Induction of gamma interferon and nitric oxide by truncated pneumolysin that lacks pore-forming activity. (2002)
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• [Journal Article] Essential role of interleukin 12 (IL-12) and II-18 for gamma interferon production induced by listeriolysin O in the spleen cells of mice. (2002)
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• [Journal Article] Dissociated linkage of cytokine-inducing activity and cytotoxicity to different domains of listeriolysin O from Listeria monocytogenes. (2002)
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• [Journal Article] Small anti-viral compounds activate immune cells via the TLR7-MyD88-dependent signaling pathway. (2002)
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• [Journal Article] Role of TLR1 in mediating immune response to microbial lipoproteins. (2002)
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• [Journal Article] Essential role for TIRAP in activation of the signaling cascade shared by TLR2 and TLR4. (2002)
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• [Journal Article] SLAM (CD150) independent measles virus entry as revealed by recombinant virus expressing green fluorescent protein. (2002)
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• [Journal Article] SERA (SERA5) is predominantly expressed among the SERA multigene family of Plasmodium falciparum and the acquired antibody titers correlate with serum inhibition of the parasite growth. (2002)
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• [Journal Article] Plasmodium falciparum serine repeat protein, a new target of monocyte-dependent antibody-mediated parasite killing. (2002)
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• [Journal Article] Characterization of proteases involved in the processing of Plasmodium falciparums erine repeat antigen (SERA). (2002)
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• [Journal Article] Consitiutive OX40/OX40 ligand interaction induces autoimmune-like diseases. (2002)
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• [Journal Article] Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases. (2002)
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• [Journal Article] Overexpression of IL-15 in vivo Increases antigen driven memory CD8^+T cells following a microbe exposure. (2002)
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• [Journal Article] Toll-like receptor 2 contributes to liver injury induced by Salmonella infection through Fas ligand expression on NKT cells in mice. (2002)
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  • Journal Title: Gastroenterology 123 Pages: 1265-1277
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• [Journal Article] Fibroblast growth factor-2 determines severity of joint disease in adjuvant-induced arthritis in rats. (2002)
  • Author(s): Yamashita A, Yonemitsu Y, Okano S, Nakagawa K, Nakashima Y, Irisa T, Iwamoto Y, Nagai Y, Hasegawa M, Sueishi K.
  • Journal Title: J Immunol. 168(1) Pages: 450-457
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• [Journal Article] Alteration of Sendai virus morphogenesis and nucleocapsid incorporation due to mutation of cysteine residues of the matrix protein. (2002)
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  • Journal Title: J Virol. 2002 Feb;76(4) : 1682-90.
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• [Journal Article] Overexpression of IL-15 in vivo increases antigen-driven memory CD8+ T cells following a microbe exposure. (2002)
  • Author(s): Yajima T, Nishimura H, Ishimitsu R, Watase T, Busch DH, Pamer EG, Kuwano H, Yoshikai Y.
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• [Journal Article] Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. (2002)
  • Author(s): Hemmi H歩h氏Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S.
  • Journal Title: Nat Immunol. 3(2) Pages: 196-200
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• [Journal Article] Small anti-viral compounds activate immune cells via the TLR7-M yD88-dependent signaling pathway. (2002)
  • Author(s): Hemmi, H. et al.
  • Journal Title: Nature Immunol 3 Pages: 196-200
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of TLR1 in mediating immune response to microbial lipoproteins. (2002)
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  • Journal Title: J.Immunol. 169 Pages: 10-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Essential role for TIRAP in activation of the signaling cascade shar ed by TLR2 and TLR4. (2002)
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  • Journal Title: Nature. 420 Pages: 344-349
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• [Journal Article] SLAM (CD150)independent measles virus entry as revealed by rec ombinant virus expressing green fluorescent protein (2002)
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  • Journal Title: J.Virol. 76 Pages: 6743-6749
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] SERA (SERA5) is predominantly expressed among the SERA mul tigene family of Plasmodium falciparum and the acquired antibody titers correlate with serum inhibition of the parasite growth. (2002)
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• [Journal Article] Plasmodium falciparum serine repeat protein, a new target of mon ocyte-dependent antibody-mediated parasite killing. (2002)
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• [Journal Article] Characterization of proteases involved in the processing of Plasmo dium falciparumserine repeat antigen (SERA). (2002)
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• [Journal Article] Constitutive OX40/0X40 ligand interaction induces autoimmune-1 ike diseases. (2002)
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• [Journal Article] Constitutive OX40/0X40 ligand interaction induces autoimmune-1 ike diseases. (2002)
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  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Overexpression of IL-15 in vivo Increases antigen driven memory CD8+T cells following a microbe exposure. (2002)
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  • Journal Title: J.Immunol. 168 Pages: 1198-1203
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• [Journal Article] Alteration of Sendai virus morphogenesis and nucleocapsid incorporation due to mutation of cysteine residues of the matrix protein. (2002)
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  • Journal Title: J Virol. 76(4) Pages: 1682-1690
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• [Journal Article] Overexpression of IL-15 in vivo increases antigen-driven memory CD8+ T cells following a microbe exposure. (2002)
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• [Journal Article] Essential role of domain 4 of pneumolysin from Streptococcus pneumoniae in cytolytic activity as determined by truncated proteins. (2001)
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  • Journal Title: Biochem. Biophys. Res. Comm. 281 Pages: 37-41
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• [Journal Article] Difference in cholesterol-binding and cytolytic activities between listeriolysin O and seeligeriolysin O : a possible role of Ala residue of Trp-rich undercapeptide. (2001)
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  • Journal Title: FEMS Microbiol. Lett. 203 Pages: 185-190
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• [Journal Article] Sporothrix schenkii thermo-tolerant mutants losing fatal visceral infectivity but retaining high cutaneous infectivity. (2001)
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  • Journal Title: Med. Mycol. 39 Pages: 295-298
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• [Journal Article] Role of macrophage scanvenger receptors in response to Listeria monocytogenes infection in mice. (2001)
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  • Journal Title: Amer. J. Pathol. 158 Pages: 179-188
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• [Journal Article] Recembinant Sendai virus-mediated gene transfer to vasculature : a new class of efficient gene transfer vector to the vascular system. (2001)
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  • Journal Title: FASEB J. 15(7) Pages: 1294-1296
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• [Journal Article] Naturally occurring deletional mutation in the C-terminal cytoplasmic tail of CCR5 affects surface trafficking of CCR5. (2001)
  • Author(s): Shioda T, Nakayama EE, Tanaka Y, Xin X, Liu H, Kawana-Tachikawa A, Kato A, Sakai Y, Nagai Y, Iwamoto A
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• [Journal Article] Y2, the smallest of the Sendai virus C proteins, is fully capable of both cunteracting the antiviral action of interferons and inhibiting viral RNA synthesis. (2001)
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• [Journal Article] Quintuple deglycosylation mutant of simian immunodeficiency virus SIVmac239 in thesus macaques : robust primary replication, tightly contained chronic infection, and elicitation of potent immunity against the parental wild-rype strain. (2001)
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• [Journal Article] Augmentation of human immunodeficiency virus type 1 subtype E (CRF01_AE) multiple-drug resistance by insertion of a foreign 11-amino-acid fragment into the reverse transcriptase. (2001)
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• [Journal Article] Rapid appearance of secondary immune responses and protection from acute CD4 depletion after a highly pathogenic immunodeficiency virus challenge in macaques vaccinated with a DNA prime/Senda virus vector boost regimen. (2001)
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• [Journal Article] Bug detectors. (2001)
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• [Journal Article] Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice. (2001)
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• [Journal Article] Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis. (2001)
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• [Journal Article] Natural human immunoglobulin G subclass responses to Plasmodium falciparum serine repeat antigen in Uganda. (2001)
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  • Journal Title: Am J Trop Med Hyg. 65(6) Pages: 912-917
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• [Journal Article] Morbilliviruses use signaling lymphocyte activation molecules (CD150) as cellular receptors. (2001)
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• [Journal Article] Measles viruses on throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not CD46 as a cellular receptor. (2001)
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• [Journal Article] V domain of human SLAM (CDw150) is essential for its function as a measles virus receptor. (2001)
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• [Journal Article] Gelatinase biosynthesis-activation pheromone : a peptide lactone that mediates a quorum sensing in Enterococcus faecalis. (2001)
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• [Journal Article] A novel mitogen-activated protein kinase phospatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines. (2001)
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• [Journal Article] Recombinant Sendai virus-mediated gene transfer to vasculature: a new class of efficient gene transfer vector to the vascular system. (2001)
  • Author(s): Masaki I, Yonemitsu Y, Komori K, Ueno H, Nakashima Y, Nakagawa K, Fukumura M, Kato A, Hasan MK, Nagai Y, Sugimachi K, Hasegawa M, Sueishi K.
  • Journal Title: FASEB J. 15(7) Pages: 1294-1296
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Naturally occurring deletional mutation in the C-terminal cytoplasmic tail of CCR5 affects surface trafficking of CCR5. (2001)
  • Author(s): Shioda T', Nakayama EE, Tanaka Y, Xin X, Liu H, Kawana-Tachikawa A, Kato A, Sakai Y, Nagai Y, Iwamoto A.
  • Journal Title: J Virol. 75(7) Pages: 3462-3468
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• [Journal Article] Y2, the smallest of the Sendai virus C proteins, is fully capable of both counteracting the antiviral action of interferons and inhibiting viral RNA synthesis. (2001)
  • Author(s): Kato A, Ohnishi Y, Kohase M, Saito S, Tashiro M, Nagai Y.
  • Journal Title: J Virol. 75(8) Pages: 3802-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Quintuple deglycosylation mutant of simian immunodeficiency virus SIVmac239 in rhesus macaques : robust primary replication, tightly contained chronic infection, and elicitation of potent immunity against the parental wild-type strain. (2001)
  • Author(s): Mori K, Yasutomi Y, Ohgimoto S, Nakasone T, Takamura S, Shioda T', Nagai Y.
  • Journal Title: J Virol. 75(9) Pages: 4023-4028
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Augmentation of human immunodeficiency virus type 1 subtype E (CRFO1_AE) multiple-drug resistance by insertion of a foreign 11-amino-acid fragment into the reverse transcriptase. (2001)
  • Author(s): Sato H, Tomita Y, Ebisawa K, Hachiya A, Shibamura K, Shiino T, Yang R, Tatsumi M, Gushi K, Umeyama H, Oka S, Takebe Y, Nagai Y.
  • Journal Title: J Virol. 75(12) Pages: 5604-5613
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rapid appearance of secondary immune responses and protection from acute CD4 depletion after a highly pathogenic immunodeficiency virus challenge in macaques vaccinated with a DNA prime/Sendai virus vector boost regimen. (2001)
  • Author(s): Matano T, Kano M, Nakamura H, Takeda A, Nagai Y.
  • Journal Title: J Virol. 75(23) Pages: 11891-11896
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bug detectors. (2001)
  • Author(s): Kaisho T', Akira S.
  • Journal Title: Nature 414(6865) Pages: 701-703
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Natural human immunoglobulin G subclass responses to Plasmodium falciparum serine repeat antigen in Uganda. (2001)
  • Author(s): Okech BA, Nalunkuma A, Okello D, Pang XL, Suzue K, Li J, Horii T, Egwang TG
  • Journal Title: Am J Trop Med Hyg. 65(6) Pages: 912-917
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gelatinase biosynthesis-activating pheromone : a peptide lactone that mediates a quorum sensing in Enterococcus faecalis. (2001)
  • Author(s): Nakayama J, Cao Y, Horii T, Sakuda S, Akkermans AD, de Vos WM, Nagasawa H.
  • Journal Title: Mol Microbiol. 41(1) Pages: 145-154
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines. (2001)
  • Author(s): Matsuguchi T, Musikacharoen.T, Johnson TR, Kraft AS, Yoshikai Y.
  • Journal Title: Mol Cell Biol. 21(20) Pages: 6999-7009
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. (2001)
  • Author(s): Hemmi H, Kaisho T, Takeuchi 0, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S.
  • Journal Title: Nat Immunol. 3(2) Pages: 196-200
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] terminal domain of murine coronavirus receptor CEACAM1 is responsible for fusogenic activation and conformational changes of the spike protein. (2000)
  • Author(s): Miura S H, Nakagaki K, Taguchi F. N
  • Journal Title: Journal of Virology 78 Pages: 216-223
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 新感染症学(上巻)「感染防御機構における自然記憶リンパ球の役割」 (2007)
  • Author(s): 吉開泰信
  • Total Pages: 109-112
  • Publisher: 日本臨床社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 免疫実験法ハンドブック (2007)
  • Author(s): 吉開泰信
  • Publisher: 名古屋大学出版社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] エッセンシャル免疫学(監訳笹月健彦)「免疫応答による正常組織の破壊」 (2007)
  • Author(s): 山田久方, 吉開泰信
  • Total Pages: 343-375
  • Publisher: メヂカルサイエンスインターナショナル
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 結核改訂第4版(分担執筆) (2006)
  • Author(s): 光山正雄
  • Total Pages: 458
  • Publisher: 医学書院
  • Description: 「研究成果報告書概要(和文)」より
• [Book] メルクマニュアル日本語版第18版(監訳) (2006)
  • Author(s): 光山正雄
  • Total Pages: 3369
  • Publisher: 日経BP社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Autophagy in Immunity and infection (2006)
  • Author(s): Ogawa, M., Sasakawa, C.
  • Total Pages: 250
  • Publisher: WILEY-VCH
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 解明が進むウィルス・細菌 感染と免疫応答 (2006)
  • Author(s): 小川道永, 笹川千尋
  • Total Pages: 226
  • Publisher: 羊土社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 微生物感染学(編著) (2005)
  • Author(s): 光山正雄
  • Total Pages: 312
  • Publisher: 南山堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 実験医学 (2005)
  • Author(s): 綿矢 有佑, 金 恵淑
  • Total Pages: 5
  • Publisher: 5.抗マラリア薬の開発 : 過去-現在-未来
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Experimental models of multiple sclerosis (2005)
  • Author(s): Taguchi F
  • Total Pages: 821-831
  • Publisher: Springer
  • Description: 「研究成果報告書概要(和文)」より
• [Book] In Biology of Negative Strand RNA Viruses, Y. Kawaoka(ed). Springer (2004)
  • Author(s): Nagai Y., Kato, A
  • Total Pages: 197-248
  • Publisher: Accessory genes of the paramyxoviridae, alarge family of nonsegmented negative-strand RNA viruses as a focus of active investigation by reverse genetics.
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 実験医学別冊 : 感染実験 (2004)
  • Author(s): 野村 卓正, 光山正雄
  • Total Pages: 243
  • Publisher: 羊土社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 別冊医学のあゆみ サイトカイン-Satate of Arts- (2004)
  • Author(s): 光山正雄
  • Total Pages: 406
  • Publisher: 医歯薬出版
  • Description: 「研究成果報告書概要(和文)」より
• [Book] ウイルス・細菌と感染症がわかる(吉開泰信編)「感染症の発症機構-病原体と宿主の攻防」、「微生物感染とたたかう生体防御機構」 (2004)
  • Author(s): 吉開泰信
  • Total Pages: 12-18, 68-77
  • Publisher: 羊土社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] シンプル免疫学(中島泉, 高橋利忠, 吉開泰信共著)「感染に対する免疫 免疫の障害 : 免疫不全症」 (2004)
  • Author(s): 吉開泰信
  • Total Pages: 109-150
  • Publisher: 南江堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] サイトカイン/ケモカインのすべて-基礎から最新情報まで「IL-15」(笠原晋平, 松島綱治編) (2004)
  • Author(s): 吉開泰信
  • Total Pages: 221-231
  • Publisher: 日本医学館
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Annual Review 呼吸器2003(分担執筆) (2003)
  • Author(s): 河村 伊久雄, 光山正雄
  • Total Pages: 282
  • Publisher: 中外医学社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] ブラック微生物学(分担翻訳) (2003)
  • Author(s): 光山正雄
  • Total Pages: 866
  • Publisher: 丸善
  • Description: 「研究成果報告書概要(和文)」より
• [Book] カレントメディカル診断と治療第42版(分担監訳) (2003)
  • Author(s): 光山正雄
  • Total Pages: 1923
  • Publisher: 日経BP社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 毒素タンパク質 II植物・微生物由来毒素タンパク質 (2003)
  • Author(s): 光山正雄
  • Total Pages: 201
  • Publisher: 廣川書店
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Annual Review免疫 2004(分担執筆) (2003)
  • Author(s): 光山正雄
  • Total Pages: 315
  • Publisher: 中外医学社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 免疫生物学-免疫系の正常と病理(笹月健彦監訳)「リンパ球の発生と選択」 (2003)
  • Author(s): 吉開泰信
  • Total Pages: 221-293
  • Publisher: 南江堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Bacterial Invasion of Host Cells (2003)
  • Author(s): Sasakawa, Chihiro
  • Publisher: CAMBRIDGE UNIVERSITY PRESS
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 細菌毒素ハンドブック(分担執筆) (2002)
  • Author(s): 光山正雄, 幸田 力
  • Total Pages: 587
  • Publisher: サイエンスフォーラム社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 別冊・医学のあゆみ 免疫疾患(分担執筆) (2002)
  • Author(s): 光山正雄, 河村 伊久雄
  • Total Pages: 570
  • Publisher: 医療薬出版
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 標準微生物学第8版(分担執筆) (2002)
  • Author(s): 光山正雄
  • Total Pages: 559
  • Publisher: 医学書院
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 細菌学(分担執筆) (2002)
  • Author(s): 光山正雄
  • Total Pages: 706
  • Publisher: 朝倉書店
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 感染症の宿主防御機構-理論と実際-(分担執筆) (2002)
  • Author(s): 光山正雄, 河村 伊久雄
  • Total Pages: 279
  • Publisher: 医療ジャーナル社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 戸田新細菌学改訂32版(分担執筆) (2002)
  • Author(s): 光山正雄
  • Total Pages: 1042
  • Publisher: 南山堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 標準免疫学第2版(分担執筆) (2002)
  • Author(s): 光山正雄
  • Total Pages: 522
  • Publisher: 医学書院
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 結核(分担執筆) (2001)
  • Author(s): 光山正雄
  • Total Pages: 414
  • Publisher: 医療ジャーナル社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 臨床微生物学ナンドブック (2001)
  • Author(s): 光山正雄
  • Total Pages: 411
  • Publisher: 医療ジャーナル社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] In virus Vectors, K. L. Hefferon(ed). Transworld Research Network.
  • Author(s): Nagai Y., Inoue, M., Iida, A., Zhu Y-F., Hasegawa M., Kato A., Matsuno T.
  • Publisher: Sendai virus engineering : From reverse genetics to vector development.(in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] ヘムヘの配置能を有する抗マラリア活性化合物 (2006)
  • Inventor(s): 樋口恒彦, 大宮弘久, 梅澤直樹, 金恵淑, 綿矢有佑
  • Industrial Property Rights Holder: 樋口恒彦
  • Industrial Property Number: 特願2006-49678
  • Filing Date: 2006-02-28
  • Description: 「研究成果報告書概要(和文)」より