| Project/Area Number |
13470015
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Kyushu Institute Of Technology (2002-2003)
Kyushu University (2001) |
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Principal Investigator |
AOU Shuji Kyushu Institute Of Technology, Graduate School rife Science and Systems Engineering, Professor, 大学院・生命体工学研究科, 教授 (40150908)
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| Co-Investigator(Kenkyū-buntansha) |
OMURA Minoru Kyushu University, Department of Hygiene, Graduate School of Medical Sciences, Associate Professor, 大学院・農学研究院, 助手 (50243936)
OSHIMA Yuji Kyushu Institute Of Technology, Laboratory of Marine Environmental Science, Institute of Marine Biological Chemistry, Associate Professor, 大学院・農学研究院, 助教授 (70176874)
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| Project Period (FY) |
2001 – 2003
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| Keywords | encironmental endocrine disrupters / green odors / homeostasis / locus coeruleus / stress / emotion / sexual differentiation / environmental chemicals |
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| Research Abstract |
The central nervous system is highly sensitive to endogenous and exogenous chemicals. Catecholamines, neuropeptides and environmental chemicals such as endocrine disrupters and plant-derived odor substances affects many different brain functions including learning and memory, emotion, stress responses and homeostatic control of physiological systems. Changes in chemical environments modulate not only behaviors but also neuronal activities in the central nervous system. During stress conditions, NE levels are locally regulated at terminal levels by proinflammatory cytokines such as interleukin-1β. The NE system has been shown to express estrogen receptors and highly sensitive to endocrine disrupters such as bisphenol A during sexual differentiation. These finding suggest that higher brain functions such as learning and emotional control are under the influence of chemical impacts via catecholamines, cytoldnes and environmental chemicals
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