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2003 Fiscal Year Final Research Report Summary

MECHANISM OF THE HOST RANGE TRANSMISSION OF INFLUENZA VIRUS AND ITS CONTROL

Research Project

Project/Area Number 13470066
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionUniversity of Shizuoka

Principal Investigator

SUZUKI Yasuo  UNIVERSITY OF SHIZUOKA, SCHOOL OF PHARMACEUTICAL SCIENCES, PROFESSOR, 薬学部, 教授 (00046278)

Project Period (FY) 2001 – 2003
KeywordsINFLUENZA VIRUS / HEMAGGLUTININ / NEURAMINIDASE / HOST RANGE / RECEPTOR / HOST RANGE TRANSMISSION / SIALIC ACID / CARBOHYDRATE CHAIN
Research Abstract

1.We found that the amino acid No.226 in the hemagglutinin (HA) of a part of the influenza viruses isolated from quail and chicken in Hong Kong (1999), which is responsible for the recognition of the host cell receptor sialosugar chains, has been changed from bird type to human type. These indicate that the direct transmission, without the intermediate host, pig, of the quail and chicken influenza viruses transmitted from wild duck to human will be possible if the receptor binding specificity of the bird virus is changed to human type the substitution of the amino acid 226 in the HA from bird type to human type by the evolutional selection of the receptor sialo sugar chains.
2.We found a new ganglioside which binds every influenza viruses isolated from the hosy, sucu as human, bird, pig and horset, indicating that this ganglioside may be a common receptor for the influenza viruses of human and other animals.
3.The neuraminidase subtype of the human virus at the Hong Kong Flu (A/1968, H3N2) has a properties of the bird flu (stable in acidic pH). It was found that the N2 subtypes of the H3N2 human influenza viruses isolated after 1971 is not a leneage of the Hong Kong Flu N2.
4.Several new inhibitors for the influenza virus HA such as polymer carrying sialyllactosamine, cyclic peptide conncted with sialyllactose which binds receptor binding pocket in the HA, glyceroglycolipids isoated from bacteria etc. were found and isolated in this study.

  • Research Products

    (57 results)

All Other

All Publications (57 results)

  • [Publications] Mitoma, J.: "Mouse 3-phosphoglycerate dehydrogenase gene: genomic organization, chromosomal localization and promoter analysis."Gene. (印刷中). (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazuya IPJ Hidari: "In vitro and in vivo inhibitory effect of sodium chromoglycate on influenza virus infection."Biol.Pharm.Bull.. (印刷中). (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimizu, M.: "Functional analysis of mouse 3-phosphoglycerate dehydrogenase (phgdh) gene promoter in developing brain"J.Neuroscience. 78. 623-652 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Keiji Sasaki: "Design of N-acetyl-6-sulfo-D-glucosaminide-based inhibitors of influenza virus sialidase."Bioorg. & Medicinal Chem.. 12. 1367-1375 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Suzuki: "Evolutional analysis of influenza A virus N2 neuraminidase genes based on the transition of the low-pH stability of sialidase activity."FEBS LETT.. 557. 228-232 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki, T.: "Inhibition of influenza A virus sialidase activity by sulfatide."FEBS LETT.. 553. 355-359 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tadanobu Takahashi: "A molecukar mechanism for the low-pH stability of sialidase activity of influenza A virus N2 neuraminidase."FEBS LETT.. 543. 71-75 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Ohta: "Glycotentacles : Syntesis of cyclic glycopeptides toward a tailored blocker of influenza virus hemagglutinin."Angew.Chem.Int.Ed.. 42. 5186-5189 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinji Kojima: "Ruthenium complexes carrying a disialo complex-type oligosaccharide : enzymatic synthesis and its application to a luminescent probe to detect influenza viruses."Chem.Comm.. 11. 1250-1251 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazuhide Totani: "Chemoenzymatic synthesis and application of glycopolymers containing multivalent sialyloligosaccharides with a poly(L-glutamic acid) backbone for inhibition of infection by influenza viruses"Glycobiol.. 13. 315-326 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ogawa, D.: "Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction."J.Biol.Chem.. 279. 2085-2090 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yuko Matsushima-Hibiya: "Identification of glycosphingolipid receptors for pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly."J.Biol.Chem.. 278. 9972-9978 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasuyuki Imai: "Restricted Expression of Shiga Toxin Binding Sites on Mucosal Epithelium of Mouse distal colon."Infection and Immunity. 71. 985-990 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mitsuhiro Matsuda: "Therapeutic effect of sulphated hyaluronic acid, a potential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis."J.Pathol.. 198. 407-414 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Rika Komagome: "Oligosaccharides as receptor for JC virus."J.Virol.. 76. 12992-13000 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kiyoshi Ikeda: "Synthesis of 2deoxy-2, 3didehydro-N-acetylneuraminic acid nalogues modified at the C-4 and C-9 positions and their behaviour towards sialidase from influenza virus and pig liver membrene."Carbohydrate Res.. 330. 31-41 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Suzuki: "Receptor specificities of human respiroviruses."J.Virol.. 75. 4604-4613 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasuo Suzuki: "Host mediated variation and receptor binding specificity of influenza viruses (Review)."Adv.Exp.Med.Biol.. 491. 445-451 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Suzuki: "Inhibition of human parainfluenza virus type 1 sialidase by analogs of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid."Glycoconjugate J.. 18. 331-337 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tadanobu Takahashi: "Duck and Human Pandemic Influenza A viruses retain sialidase activity in Low pH conditions."J.Biochem.. 130. 279-283 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ogawa, K.: "Preventive effect of sulfated colominic acid on P-selectin-dependent infiltration of macrophages on experimentally induced crescentic glomerulonephritis."Chin.Exp.Immunol. 129. 43-53 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chao-Tan Quo: "An O-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses."Glycobiol.. 12. 183-190 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kamruddlin Ahmed: "Asialo-GM1 and Asialo-GM2 are putative adhesion molecules for Moraxella catarrhalis."Med.Microbiol.Immunol.. 191. 5-10 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hughes MT: "A viruses to cells expressing low levels of sialic acid leads neuraminidase activity."J.Virol.. 75. 3766-3770 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masafumi Kimura: "Engagement of endogenous ganglioside GM1a induces tyrosine phosphorylation involved in neuron-like differentiation of PC12 cells."Glycobiology. 11. 335-343 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takehiko Saito: "Characterization of a human H9N2 influenza virus isolated in Hong Kong."Vaccine. 20. 125-133 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Suzuki: "Receptor specificities of human respiroviruses."J.Virol.. 75. 4604-4613 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasuo Suzuki (分担執筆): "Recent Advances in Influenza Virus Res 2002"Research Signpost. 185 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasuo Suzuki (分担執筆): "Options for the control of Influenza IV Ed.A.Osterhaus, N.Cox, A.Hampson"Excerpta Media International Congress Series Published Elsevier Science B.V.. 203 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazuya I.J.Hidari, Eisaku Tsujii, Jun Hiroi, Eriko Mano, Akihiko Miyatake, Daisei Miyamoto, Takashi Suzuki, Yasuo Suzuki: "In Vitro and In Vivo Inhibitory Effects of Disodium Cromoglycate on Influenza Virus Infection."Biological Phamaceutical Bulletin. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitoma, J., Furuya, S., Shimizu, M., Sinoda, Y., Yoshida, K., Azuma, N., Tanaka, H., Suzuki, Y., Hirabayashi, Y.: "Mouse 3-phosphoglycerate dehydrogenase gene : genomic organization, chromosomal localization, and promoter analysis."Gene. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimizu, M., Furuya, S., Shinoda, Y., Mitoma, J., Okamura, T., Miyoshi, I., Kasai, N., Hirabayashi, Y., Suzuki, Y.: "Functional analysis of mouse 3-phosphoglycerate dehydrogenase (phgdh) gene promoter in developing brain"J.Neuroscience Res.. 78. 623-632 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Suzuki, Tadanobu Takahashi, Takehiko Saito, Chao-Tan Guo, Kazuya I.-Jwa Hidari, Daisei Miyamoto, Yasuo Suzuki: "Evolutional analysis of influenza A virus N2 neuraminidase genes based on the transition of the low-pH stability of sialidase activity."FEBS LETT. 557. 228-232 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Keiji Sasaki, Yoshihiro Nishida, Mikie Kambara Hirotaka Uzawa, Tadanobu Takahashi, Takashi Suzuki, Yasuo Suzuki, Kazukiyo Kobayashi: "Design of N-acetyl-6-sulfo-D-glucosaminide-based inhibitors of influenza virus sialidase."Bioorg. & Medicinal Chem.. 12. 1367-1375 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tadanobu Takahashi, Takashi Suzuki, Kazuya I.-Jwa Hidari, Daisei Miyamoto, Yasuo Suzuki: "A molecukar mechanism for the low-pH atability of sialidase activity of influenza A virus N2 neuraminidase."FEBS LETT.. 543. 71-75 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogawa, D., Shikata, K., Honke, K., Sato, S., Sato, S., Matsuda, M., Nagase, R., Tone, A., Okada, S., Usui, H., Wada, J., Miyasaka, M., Kawashima, H., Suzuki, Y., Suzuki, T., Tanuguchi, N., Hiraharam Y., Tadano-Aritomi K., Ishizuka, I., Tedder, TF, Makino H.: "Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction."J.Biol.Chem.. 279. 2085-2090 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shinji Kojima, Teruaki Hasegawa, Takahiro Yonemura, Ken Sasaki, Kenji Yamamoto, Yutaka Makimura, Tadanobu Takahashi, Takashi Suzuki, Yasuo Suzuki, Kazukiyo Kobayashi: "Ruthenium complexes carrying a disialo complex-type oligosaccharide : enzymatic synthesis and its application to a luminescent probe to defect influenza viruses."Chem.Comm.(The royal Society of Chemistry, Advance Article). DOI:10.1039/b210739b (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yuko Matsushima-Hibiya, Masahiko Watanabe, Kazuya Hidari, Daisei Miyamoto, Yasuo Suzuki, Takeshi Kasama, Takashi Kanazawa, Kotaro Koyama, Takashi Sugimura, Keiji Wadabayashi: "Identification of glycosphingolipid receptors for pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly."J.Biol.Chem.. 278. 9972-9978 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohta, T., Miura, N., Fujitani, N., Nakajima, F., Niikura, K., Chao-Tan Guo, Suzuki, T., Suzuki, Y., Monde, K., Nishimura: "S.-I.Glycotentacles : Synthesis of cyclic glycopeptides toward a tailored blocker of influenza virus hemagglutinin."Angew.Chem.Int.Ed.. 42(42). 586-5159 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, T., Takahashi, T., Nishinaka, D., Murakami, M., Fujii, S., Hidari, I.--Jwa K., Miyamoto, D., Li, Y.-T., Suzuki, Y.: "Inhibition of influenza A virus sialidase activity by sulfatide."FEBS LETT.. 553. 355-359 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kazuhide Totani, Takeshi Kubota, Takao Huroda, Takeomi Murata, Kazuya I.-Jwa Hidari, Takashi Suzuki, Yasuo Suzuki, Kazukiyo Kobayashi, Hisashi Ashida, Kenji Yamamoto, Taichi Usui: "Chemoenzymatic synthesis and application of glycopolymers containing multivalent sialyloligosaccharides with a poly(L-glutamic acid) backbone for inhibition of infection by influenza viruses."Glycobiology. 13(5). 315-326 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuyuki Imai, Takashi Fukui, Khota Kurohane, Daisei Miyamoto, Yasuo Suzuki, Tomoyuki Ishikawa, Yousuke Ohno, Masaki Miyake: "Restricted Expression of Shiga Toxin Binding Sites on Mucosal Epithelium of Mouse diatal colon."Infection and Immunity. 71, No.2. 985-990 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mituhiro Matsuda, Kenichi Sikata, Fujio Shimizu, Yasuo Suzuki, Masayuki Miyasaka, Hiroshi, Kawachi, Hiroto Kawashima, Jun Wada, Hikaru Sugimoto, Yasushi Shikata, Daisuke Ogawa, Shinichiro J. Tojo, Kazuo Akima, Hirofumi Makino: "Therapeutic effect of sulphated hyaluronic acid, a potential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis."J.Pathol.. 198. 407-414 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Rika Komagome, Hirofumi Sawa, Takashi Suzuki, Yasuo Suzuki, Shinya Tanaka, Walter J.Atwood, Kazuo Nagashima: "Oligosaccharides as receptor for JC virus."J.Virol.. 76. 12992-13000 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] D.Ogawa, K.Shikata, M.Matsuda, S.Okada, J.Wada, S.Yamaguchi, Y.Suzuki, M.Miyasaka: "Preventive effect of sulfated colominic acid on P-selectin-dependent infiltration of macrophages on experimentally induced crescentic glomerulonephritis."Clin.ExImmunol.. 129. 43-53 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chao-Tan Guo, Xue-Long Sun, Osamu Kanie, Kennedy Francis Shortridge, Takashi Suzuki, Daisei Miyamoto, Kazuya I.-Jwa Hidari, Chi-Huey Wong, Yasuo Suzuki: "An O-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidse activities of influenza viruses."Glycobiol.. 12. 183-190 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kamruddlin Ahmed, Yasuo Suzuki, Daisei Miyamoto, Tsuyoshi Nagatake: "Asialo-GM1 and Asialo-GM2 are putative adhesion molecules for Moraxella catarrhalis."Med.Microbiol.Immunol.. 191. 5-10 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuo Suzuki: "Receptor binding specificity and host range variation of influenza viruses (Review)."Recent Advance in Influenza Virus Res 2002.(Ed., Y.Hayase)(Research Signpost). 161-168 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hughes MT, McGregor M, Suzuki T, Suzuki Y, Kawaoka Y.: "Adaptation of influenza A viruses to cells expressing low levels of sialic acid leads neuraminidase activity."J.Virol.. 75(8). 3766-3770 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masafumi Kimura, Kazuya I.-Jwa Hidari, Takashi Suzuki, Daisei Miyamoto, Yasuo Suzuki.: "Engagement of endogenous ganglioside GM1a induces tyrosine of endogenous ganglioside GM1a induces tyrosine phosphorylation involved in neuron-like differentiation of PC12 cells."Glycobiology. 11(4). 335-343 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kiyoshi Ikeda, Kimihiko Sano, Masaki Ito Kazuya idari, Takashi Suzuki, Yasuo Suzuki, Kiyoshi Tanaka: "Synthesis of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid nalogues modified at the C-4 and C-9 positions and their behaviour towards sialidase from influenza virus and pig liver membrene."Carbohydrate Res.. 330. 31-41 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Suzuki, Allen Portner, Ruth Ann Scroggs, Makoto Uchikawa, Noriko Koyama, Kazuko Matsuo, Yasuo Suzuki, Toru Takimoto: "Receptor specificities of human respiroviruses."J.Virol.. 75(10). 46-4-4613 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Suzuki, Kiyoshi Ikeda, Noriko Koyama, Chika Hosokawa, Toshuhiro Kogure, Tadanobu Takahashi, Kazuya I.-Jwa Hidari, Daisei Miyamoto, Kiyoshi Tanaka, Yasuo Suzuki: "Inhibition of human parainfluenza virus type 1 sialidase by analogs of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid."Glycoconjugate J.. 18. 331-337 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tadanobu Takahashi, Yasuo Suzuki, Daisuke Nishimura, Nana Kawase, Yukiko Kobayashi, Kazuya I.-Jwa Hidari, Daisei Miyamoto, ChaoTan Guo, Kennedy F.Shortridge, Takashi Suzuki: "Duck and Human Pandemic Influenza A viruses retain sialidase activity in Low pH conditions."J.Biochem.. 130(2). 279-283 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Cao-Tan Guo, shinji Ohta, Akihiro Yoshimoto, Kuniho Nakata, Kennedy F.Shortridge, Tadanobu Takahashi, Takashi Suzuki, Daisei Miyamoto, Kazuya I.-Iwa Hidari, Yasuo Suzuki: "A unique phosphatidylinositol bearing a novel branched-chain fatty acid from Rhodococcus equi binds to influenza virus hemagglutinin and inhibits the infection of cells."J.Biochem.. 130. 377-384 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takehiko Saito, Wilina Lim, Takashi Suzuki, Yasuo Suzuki, Hiroshi Kida, Shin-Ichiro Nishimura, Masato Tashiro: "Characterization of a human H9N2 influenza virus isolated in Hong Kong."Vaccine. 20(1-2). 125-133 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuo Suzuki, Toshihiro Ito, Takashi Suzuki, Daisei Miyamoto, Kazuya I.-J.Hidari, Chao-Tan Guo, Hiroshi Kida, Robert G.Webster, Thomas M.Chambers, Yoshihiro Kawaoka: "Sialyl sugar chains as receptors and determinants of host range of influenza A viruses."Options for the control of Influenza IV(Excerpta Media International Congress Series)(Ed. A.Osterhaus, N.Cox, A.Hampson)(Published Elsevier Science B.V.). 1219. 521-525 (2001)

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      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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