2003 Fiscal Year Final Research Report Summary
The epidemiological study regarding the gene-lifestyle interaction on hypertension
| Project/Area Number |
13470085
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Tohoku University |
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Principal Investigator |
TSUJI Ichiro Tohoku University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (20171994)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUBARA Mitsunobu Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (30282073)
IMAI Yutaka Tohoku University, Graduate School of Pharmaceutical Science, Professor, 大学院・薬学研究科, 教授 (40133946)
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| Project Period (FY) |
2001 – 2003
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| Keywords | Hypertension / Community based study / Ambulatory blood pressure / Home blood pressure / Gene polymorphisms / Lifestyle / Circulatory disease epidemiology / Risk factors |
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| Research Abstract |
We investigated the relationship between gene polymorphisms and blood pressure (BP), especially BP measured at home (home EP, HBP) or ambulatory BP (ABP), using blood sample obtained from Ohasama residents. We showed the summary of articles which was published in last year.
1)Heat rate and outcome.
This review article summarizes the reports which investigated the relationship between heart rate (HR) and cardiovascular outcomes in Ohasama residents. Home measured HR linearly related to the cardiovascular disease mortality, while HR variability measured by device for ABP inversely related to the cardiovascular mortality. HR and HR variability must not be overlooked when evaluating hypertension.
2)Gene polymorphisms of rennin-angiotensin system and blood pressure.
The angiotensinogen gene polymorphisms (AGT) M235T has been investigated in association with essential hypertension based on conventional measurement of BP ; however, the results have been inconsistent. We investigated the relationship between AGT and HBP value. There was no significant difference among the genotypes in home BP values or in prevalence of hypertension. No difference was noted in the frequency of familial history of hypertension. Pulse pressure, however, was significantly different among the genotypes (P=0.049), and this association was prominent in the older population (Paper 2).
We also investigated the relationship between the angiotensin II type 1 receptor (AT1) gene and ABP. We investigated 802 subjects who were 40 years or over. Although daytime BP was higher in subjects with C allele, the difference was not statistically significant after adjusting possible confounders. No significant difference was noted in the prevalence of cardiovascular diseases of nocturnal decline between the groups. These results indicated that AT1 polymorphism was not associated with any clinical parameters associated with hypertension or atherosclerosis in the Japanese (Paper 3).
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