2003 Fiscal Year Final Research Report Summary
The role of mastication in the mechanism of regulation of energy metabolism
| Project/Area Number |
13470453
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
矯正・小児・社会系歯学
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| Research Institution | Kyushu University |
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Principal Investigator |
FUJISE Takako Kyushu University Hospital, Res.Associate, 大学病院, 助手 (50284518)
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| Co-Investigator(Kenkyū-buntansha) |
NINOMIYA Yuzo Kyushu University, Faculty of Dental Science, Professor, 大学院・歯学研究院, 教授 (50076048)
YOSHIMATSU Hironobu Oita University, Faculty of Medicine, Professor, 医学部, 教授 (00166993)
SAKATA Toshiie Nakamura Gakuen University, Faculty of Health and Nutrition Science, Professor, 栄養科学部, 教授 (50037420)
OCHIAI Satoru Kyushu University Hospital, Res.Associate, 大学病院, 助手 (20315097)
SASAKI Yasunori Kyushu University, Faculty of Dental Science, Res.Associate, 大学院・歯学研究院, 助手 (70332848)
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| Project Period (FY) |
2001 – 2003
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| Keywords | mastication / energy metabolism / Diet-induced thermogenesis / obesity / taste / neuronal histamine / sympathetic nervous system |
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| Research Abstract |
The oral cavity is not only the site of the first stage in digestion but also the brain's source of sensory information about the food. We have shown the function of hypothalamic neuronal histamine(HA) activated by mastication began earlier in the mesencephalic trigeminal nucleus, and later in the hypothalamus due to a signal originating from the oral proprioceptors and initiated by chewing. The preabsorptive thermogenesis in the rats fed with soft or liquid diets decreased in comparison with that of the rats fed with hard pellets without changing locomotive activities. The rats depleted HA or the intraperitoneal pretreated rats with a beta-adorenoceptor antagonistfed with hard pellets showed reduced thermogenesis at the preabsorptive phase compared to that of the saline controlled rats. Postprandial thermogenesis associated with mastication is partly mediated by histaminergic system and sympathetically mediated through beta-receptors in rats. The long-term deficiency of thermogenesis associated with a soft or liquid food attenuates a lipolysis related the histaminergic function in the adipose tissue and results in a greater tendency for obesity without increase the energy intake.
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Research Products
(10 results)
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[Publications] Oka, K., Sakurae, A., Fujise, T., Yoshimatsu, H., Sakata, T., Nakata, M.: "Food texture differences affect energy metabolism in rats."Journal of Dental Research. 82(6). 491-494 (2003)
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「研究成果報告書概要(欧文)」より
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[Publications] Murata, Y., Nakashima, K., Yamada, A., Shigemura, N., Sasamoto, K., Ninomiya, Y.: "Gurumarin suppression of licking responses to sweetener-quinine mixture in C57BL mice."Chem.Senses. 28. 237-243 (2003)
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「研究成果報告書概要(欧文)」より
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[Publications] Katsukawa, H., Shang, Y, Nakashima, K, Yang, K.H., Ohashi, R., Sugita, D., Mishima, K., Nakata, M., Ninomiya, Y., Sugimura, H.: "Salivary cystatins influence ingestion of capsaicin-containing diets in the rat."Life Science. 71. 457-467 (2002)
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「研究成果報告書概要(欧文)」より
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[Publications] Hidaka, S., Yoshimatsu, H., Kondou, S., Oka, K., Tsuruta, Y., Sakino, H., Itateyama, E., Noguchi, H., Himeno, K., Okamoto, K., Teshima, Y., Oketa, T., Sakata, T.: "Hypoleptinemia, but not hypoinsulinemia, induces hyperphagia in streptozotocin-induced diabetic rats"Journal of Neurochemistry. 77. 993-1000 (2001)
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「研究成果報告書概要(欧文)」より
