2002 Fiscal Year Final Research Report Summary
Positional cloning of genes responsible for animal behavior and analysis of gene polymorphisms as a tool for genetic analysis
| Project/Area Number |
13480282
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | NATIONAL INSTITUTE OF GENETICS |
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Principal Investigator |
KOIDE Tsuyoshl GENETIC STRAINS RESEARCH CENTER, ASSOCIATE PROFESSOR, 系統生物研究センター, 助教授 (20221955)
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| Co-Investigator(Kenkyū-buntansha) |
SHIROISHI Toshihiko GENETIC STRAINS RESEARCH CENTER, PROFESSOR, 系統生物研究センター, 教授 (90171058)
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| Project Period (FY) |
2001 – 2002
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| Keywords | Wild mouse / Behavior / Genetics / Polymorphism / Genetic mapping / OTL |
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| Research Abstract |
We previously conducted multi-phenotype behavioral characterizations using a series of inbred strains derived from wild mice in addition to the common laboratory strains, the Mishima battery of mouse strains. In the study of spontaneous locomotor activity in the habituated normal home cages using infrared sensor, we found that mice of KJR strain was hyperactive in contrast to mice of BLG2 strain, which showed a low level of spontaneous locomotion. To unravel the genetic loci involved in this behavioral phenotype, we conducted QTL analysis on backcross populations of a cross between KJR and BLG2 strains. In the QTL analysis with 282 backcross progeny, two loci were found to be involved in the different spontaneous activity.
In the systematic screening in the public database for genes carrying poly-glutamine repeats in the products, we listed 50 genes in total We analyzed variation of the repeat length in the 62 loci among 16 inbred strains of mouse by PCR analysis followed by DNA sequencing. We fond high degree of polymorphism among strains.
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Research Products
(8 results)
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[Publications] Furuse, T., Blizard, D. A., Moriwaki, K., Miura, Y., Yagasaki, K., Shiroishi, T., Koide, T.: "Genetic diversity underlying capsaicin intake in the Mishima battery of mouse strains"Brain Research Bulletin. 57. 49-55 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Chan, B. W. H., Chan, K.-S., Koide, T., Yeung, S.-M., Leung, M. B. W., Copp, A. J., Loeken, M. R., Shiroishi, T., Shum, A. S. W.: "Maternal Diabetes Increases the Risk of Caudal Regression Caused by Retinoic Acid"Diabetes. 51. 2811-2816 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Isobe, T., Yoshino, M., Mizuno, K, Fisher Lindahl, K., Koide, T., Gaudiery, S., Gojobori, T., Shiroishi, T.: "Molecular characterization of the Pb recombination hotspot in the mouse major histocompatibility complex class I region"Genomics. 80. 229-235 (2002)
Description
「研究成果報告書概要(欧文)」より
