2002 Fiscal Year Final Research Report Summary
Inhibitory effect of adrenomedullin on uterine contraction
| Project/Area Number |
13557009
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
General pharmacology
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| Research Institution | Miyazaki Medical College |
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Principal Investigator |
YANAGITA Toshihiko Miyazaki Medical College, Dept of Pharmacol., Research Associate, 医学部, 助手 (60295227)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Kazuo Miyazaki Medical College, Dept of Medicine, Associate Professor, 医学部, 講師 (50204912)
KOBAYASHI Hideyuki Miyazaki Medical College, Dept of Pharmacol., Associate Professor, 医学部, 助教授 (40148953)
WADA Akihiko Miyazaki Medical College, Dept of Pharmacol., Professor, 医学部, 教授 (30131949)
SAKATA Tsuneaki Sakata, Tuneaki, Shionogi Co. Ltd., Chief investigator, 基礎医薬研究部門, 主管研究員
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| Project Period (FY) |
2001 – 2002
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| Keywords | adrenomedullin / myometrium / tocolysis / pregnant uterus / placenta / decidua / mRNA expression / premature labor |
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| Research Abstract |
To clarify the role of adrenomedullin (AM) in the female reproductive system, we examined the effects of AM on periodic uterine contraction in nonpregnant and pregnant rats.
1. In isolated uterine strips of nonpregnant rat, adrenomedullin (AM) inhibited spontaneous and bradykinin-induced uterine contraction, but did not change oxytocin- or prostaglandin F_<2α>-induced uterine contraction. The inhibitory effect of AM was blocked by AM [22-52].
2. During pregnancy, levels of AM mRNA and protein were significantly increased in decidua of placenta. The myometrium isolated from placental site did not contract spontaneously, whereas the periodic and strong contraction was induced by addition of AM [22-52].
These results imply that increased level of AM in decidua inhibits the uterine contraction of placental site, and it might contribute to the maintainance of pregnancy without interfering normal labor promoted by oxytocin or PGF2_<2α>.
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