2002 Fiscal Year Final Research Report Summary
Application! Of low temperature microplasma to the treatment and diagnosis for gastrointestinal disease
| Project/Area Number |
13557046
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
WATANABE Mamoru Tokyo Medical and Dental University, Department of Gastroenterology and Hepatology, Professor, 大学院・医歯学総合研究科, 教授 (10175127)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Yuki Tokyo Institute of Technology, Frontier Collaborative Research Center, Instructor, フロンティア創造共同研究センター, 助手
MAKABE Toshiaki Keio University, Faculty of Science and Technology, Department of Electrical Engineering, Professor, 理工学部, 教授 (60095651)
ENOMOTO Nobuyuki Tokyo Medical and Dental University, Department of Gastroenterology and Hepatology, Assistant Professor, 医学部附属病院, 講師 (20251530)
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| Project Period (FY) |
2001 – 2002
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| Keywords | microplasma / low temperature plasma / endoscopy / drug / biological active substance / inflammation / cancer |
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| Research Abstract |
In this study, we have made attempts to develop new devices that can be employed through the channel of the gastrointestinal (GI) endoscopy and function as sources of low-pressure and high-density plasma, aiming at the clinical application of these microelectronic devices for delivering various chemical and/or bioactive compounds to the mucosal surface of the GI tract. One of the critical steps for the development of such device is narrowing its diameter, and, collaborating with a group of Keio University, we have successfully developed a flexible and multitask plasma processing device that is less than 1 mm in diameter. In addition, using very high frequency (VHF) power source that is recently developed, we have advanced our technology to be widely applicable to various materials. Furthermore, preliminary studies demonstrated that our device, designed to generate low temperature microplasma, showed advantages over other devices we examined with regard to the limitation of the mucosal surface damage. These devices would allow a wide variety of drugs and bioactive materials to be topically and efficiently delivered to the target molecules, such as bacterial components or the products of genes that are involved in inflammatory responses or cellular oncogenesis, and therefore, would serve as an innovative and powerful tool for diagnostic and therapeutic approaches to human diseases of the GI tract.
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Research Products
(10 results)
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[Publications] Inoue, N., Watanabe, M., Sato, T., Okazawa, A., Yamazaki, M., Kanai, T., Ogata, H., Iwao, Y., Ishii, H., Hibi, T.: "Restricted V_H gene usage in lamina propria B cells producing anticolon antibody from parients with ulcerative colitis"Gastroenterology. 121. 15-23 (2001)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Kanai, T., Watanabe, M., Okazawa, A., Sato, T., Yamazaki, M., Okamoto, S., Ishii, H., Totsuka, T., liyama, R., Okamoto, R., Ikeda, M., Kurimoto, M., Takeda, K., Akira, S., Hibi, T.: "Macrophage-derived IL-18 mediated intestinal inflammation in the murine model of Crohn's disease"Gastroenterology. 121. 875-888 (2001)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Sasazuki, T., Sawada, T., Sakon, S., Kitamura, T., Kishi, T., Okazaki, T., Katano, M., Tanaka, M., Watanabe, M., Yagita, H., Okamura, K., Nakano, H.: "Identification of a Novel Transcriptional activator, BSAC, by a Functional Cloning to Inhibit Tumor Necrosis Factor-induced Cell Death"J Biol Chem. 277. 28853-28860 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Okamoto, R., Yajima, T., Yamazaki, M., Kanai, T., Mukai, M., Okamoto, S., Ikeda, Y., Hibi, T., Inazawa, J., Watanabe, M.: "Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract"Nature Med. 8. 1011-1017 (2002)
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「研究成果報告書概要(欧文)」より
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[Publications] Totsuka, T., Kanai, T., liyama, R., Uraushihara, K., Yamazaki, M., Okamoto, R., Hibi, T., Tezuka, K., Azuma, M., Akiba, H., Yagita, H., Okumura, K., Watanabe, M.: "Ameliorating Effect of Anti-Inducible CpStimulator Monoclonal Antibody in a Murine Model of Chronic Colitis"Gastroenterology. 124. 410-421 (2002)
Description
「研究成果報告書概要(欧文)」より
