2002 Fiscal Year Final Research Report Summary
Detection of Spinal Cord Injury during Thoracoabdominal Aortic Aneurysm Surgery Using Multi-channel Superconducting Quantum Interference Device
| Project/Area Number |
13557109
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Thoracic surgery
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
SUEDA Taijiro Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (10162835)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMOTO Yoshinori Hiroshima University, Graduate School of Biomedical Sciences, Associate professor, 大学院・医歯薬学総合研究科, 助教授 (30199377)
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| Project Period (FY) |
2001 – 2002
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| Keywords | Spinal cord action magnetic field / Superconducting quantum interference device / SOUID / Evoked spinal cord potential / Magnetic shield room / Spinal cord ischemia / Aortic surgery |
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| Research Abstract |
The main purpose of the current project was to test superconducting quantum interference device (SQUID), for detecting the spinal cord conduction and for predicting spinal cord ischemia. (1) Development of SQUID system for spinal cord study (at Hiroshima University) : Detection of spinal cord action magnetic field using one-channel SQUID failed. The limitation of the performance of the one-channel device was the profound cause of this failure. (2) Spinal cord ischemia model : Ischemia was induced in adult dogs by cross-clamping the thoracic aorta for 60 min.
On April, 2002, we started to research using high performance 71-channel SQUID at NTT Docomo Multimedia Laboratories (Yokosuka, Japan). This multi-channel device has given results as follows. (3) Measurement of the peripheral compound nerve action magnetic field (CAF) and its spatial analysis : We succeeded in measuring the CAF of the human median and ulnar nerves. Nerve conduction was visualized by means of magnetography. (4) Magne
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tic analysis of ischemia-induced nerve conduction impairment : We succeeded in recording ischemic- changes of the median nerve conduction with magnetic study. Twenty -minute fore-arm ischemia was induced with the pneumatic tourniquet placing around the upper arm. The amplitude of the CAF of the median nerve significantly increased at 5 min after the initiation of ischemia, and it gradually decreased and almost completely disappeared at 20 min. Magnetographic evaluation also showed characteristic findings during early period of ischemia. (5) Development of multi -channel SQUID system for spinal cord study : A)-Spinal cord action magnetic field in rabbit ; We succeeded in visualization of ascending spinal cord conduction only in the lumbar area with magnetic study. B)-Dog study ; We failed to recording magnetic field of the canine cord because of insufficient sensor sensitivity. If this trouble is solved, we will apply an ischemia protocol for testing the current multi-channel device to detect spinal cord ischemia. Less
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