2004 Fiscal Year Final Research Report Summary
Development of intraoperative brain function endoscope with intrinsic optical imaging and fiber optics
| Project/Area Number |
13557114
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SATO Katsushige Tokyo Medical and Dental University, Graduate School, Lecturer, 大学院・医歯学総合研究科, 講師 (80291342)
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| Co-Investigator(Kenkyū-buntansha) |
MOMOSE Yoko (SATO Yoko) Tokyo Medical and Dental University, Graduate School, Lecturer, 大学院・医歯学総合研究科, 講師 (70251501)
NARIAI Tadashi Tokyo Medical and Dental University, Graduate School, Lecturer, 大学院・医歯学総合研究科, 講師 (00228090)
OHNO Kikuo Tokyo Medical and Dental University, Graduate School, Professor, 大学院・医歯学総合研究科, 講師 (50014238)
TSUMURA Harukuni Saikei, Co., System Engineering, システム機器部, 部長
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| Project Period (FY) |
2001 – 2004
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| Keywords | optical recording / intrinsic signal / fiber optic / neurosurgery / imaging / brain function endoscope / intraoperative recording / neural function |
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| Research Abstract |
We applied the intrinsic optical imaging technique to the human primary somatosensory cortex during brain tumor/epilepsy surgery for nine patients. The cortical surface was illuminated with a Xenon light through an operating microscope, and the reflected light, which passed through a 605nm bandpass filter, was detected by a CCD camera-based optical imaging system. Individual electrical stimulation of five digits induced changes in the reflected light intensities. Visualizing the intrinsic optical responses, we constructed maps of finger representation in Brodmann's area 1. In the maps, response areas of Digit I to V were sequentially aligned along the central sulcus in the crown of the postcentral gyrus from the latero-inferior region (Digit I) to the medio-superior region (Digit V). The neighboring response areas partially overlapped each other, as previously described in the monkey somatosensory cortex. Similar results were obtained in the face region with stimulation of the three branches of the trigeminal nerve. These results suggest that the overlap of the response areas is a common feature in the somatosensory cortex not only in monkeys, but also in humans.
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Research Products
(37 results)
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[Journal Article] Light-scattering signals related to neural functions.2004
Author(s)
Sato, K., Momose-Sato, Y., Kamino, K.
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Journal Title
Recent Research Developments in Membrane Biology. (Eds.Fagan, J., Davidson, J., N., Shimizu, N.)(Research Signpost, Kerara) Vol.2
Pages: 21-45
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Functional mapping of neural activity in the embryonic avian visual system : optical recording with a voltage-sensitive dye.2003
Author(s)
Miyakawa, N., Sato, K., Mochida, H., Sasaki.S., Momose-Sato, Y.
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Journal Title
The Neural Basis of Early Vision. (Ed.Kaneko, A.)(Keio University International Symposia for Life Sciences and Medicine)(Springer-Verlag, Tokyo) Vol.11
Pages: 194-198
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Intraoperative intrinsic optical imaging of neuronal activity from subdivisions of the human primary somatosensory cortex.2002
Author(s)
Sato, K., Nariai, I., Sasaki, S., Yazawa, I., Mochida, H., Miyakawa, N., Momose-Sato, Y., Kamino, K., Ohta, Y., Hirakawa, K., Ohno, K.
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Journal Title
Cerebral Cortex 12
Pages: 269-280
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Multiple-site optical recording for characterization of functional synaptic organization of the optic tectum of rainbow trout.2002
Author(s)
Kinoshita, M., Ueda, R., Kojima, S., Sato, K., Watanabe, M., Urano, A., Ito, E.
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Journal Title
European Journal of Neuroscience 16
Pages: 868-876
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Optical imaging of intrinsic signals induced by peripheral nerve stimulation in the in vivo rat spinal cord.2002
Author(s)
Sasaki, S., Yazawa, I., Miyakawa, N., Mochida, H., Shinomiya, K., Kamino, K., Momose-Sato, Y., Sato, K.
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Journal Title
NeuroImage 17
Pages: 1240-1255
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Application of voltage-sensitive dyes to the embryonic central nervous system.2002
Author(s)
Momose-Sato, Y., Sato, K., Kamino, K.
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Journal Title
Recent Research Developments in Membrane Biology. (Eds.Fagan, J., Davidson, J., N., Shimizu, N.)(Research Signpost, Kerara) Vol.1
Pages: 159-181
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Spreading depolarization waves triggered by vagal stimulation in the embryonic chick brain : optical evidence for intercellular communication in the developing CNS.2001
Author(s)
Momose-Sato, Y., Sato, K., Mochida, H., Yazawa, I., Sasaki, S., Kamino, K.
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Journal Title
Neuroscience 102
Pages: 245-262
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Multiple-site optical recording reveals embryonic organization of synaptic networks in the chick spinal cord.2001
Author(s)
Mochida, H., Sato, K., Arai, Y., Sasaki, S., Yazawa, I., Kamino, K., Momose-Sato, Y.
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Journal Title
European Journal of Neuroscience 13
Pages: 1547-1558
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Optical imaging of spreading depolarization waves triggered by spinal nerve stimulation in the chick embryo : Possible mechanisms for large-scale coactivation of the CNS.2001
Author(s)
Mochida, H., Sato, K., Arai, Y., Sasaki, S., Kamino, K., Momose-Sato, Y.
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Journal Title
European Journal of Neuroscience 14
Pages: 809-820
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Developmental changes in trial-to-trial variations in whisker barrel responses studied using intrinsic optical imaging : Comparison between normal and de-whiskered rats.2001
Author(s)
Yazawa, I., Sasaki, S., Mochida, H., Kamino, K., Momose-Sato, Y., Sato, K.
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Journal Title
Journal of Neurophysiology 86
Pages: 392-401
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Optical responses to micro-application of GABA agonists in the embryonic chick brain stem.2001
Author(s)
Sato, K., Mochida, H., Sasaki, S., Yazawa, I., Kamino, K., Momose-Sato, Y.
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Journal Title
Neuro Report 12
Pages: 95-98
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effects of anisomycin on LIP in the hippocampal CA1 : Long-term analysis using optical recording.2001
Author(s)
Mochida, H., Sato, K., Sasaki, S., Yazawa, I., Kamino, K., Momose-Sato, Y.
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Journal Title
Neuro Report 12
Pages: 987-991
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Functional representation of the finger and face in the human somatosensory cortex : Intraoperative intrinsic optical imaging.
Author(s)
Sato, K., Nariai, T., Tanaka, Y., Maehara, T., Miyakawa, N., Sasaki, S., Momose-Sato, Y., Ohno, K.
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Visualization of somatotopic representation of sensory cortex with intrinsic optical signals as guides for brain tumor surgery
Author(s)
Nariai, T., Sato, K., Hirakawa, K., Ohta, Y., Tanaka, Y., Ishiwata, K., Ishii, K., Kamino, K., Ohno, K.
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Journal Title
Journal of Neurosurgery (in press)
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Application of voltage-sensitive dyes to the embryonic nervous systems.
Author(s)
Sato, K., Momose-Sato Y., Kamino, K.
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Journal Title
Light Scattering Imaging of Neural Tissue Function. (Eds.Rector, D., M., George, J., S.)(The Humana Press Inc, Totowa) (in press)
Description
「研究成果報告書概要(欧文)」より
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