2002 Fiscal Year Final Research Report Summary
Investigation of noninvasive heating system using re-entrant type applicator for malignant brain tumor
| Project/Area Number |
13557115
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | NIIGATA UNIVERSITY |
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Principal Investigator |
TANAKA Ryuichi NIIGATA UNIVERSITY Brain Research Institute Professor, 脳研究所, 教授 (30018816)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Kazuo NAGAOKA UNIVERSITY OF TECHNOLOGY Associate Professor, 工学部, 助教授 (80115104)
TAKAHASHI Hideaki University Medical Hospital Lecturer, 医学部附属病院, 講師 (70236305)
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| Project Period (FY) |
2001 – 2002
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| Keywords | re-entrant type applicator / hyperthermia / noninvasive therapy / computer simulation / malignant brain tumor |
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| Research Abstract |
In order to reduce invasiveness of thermotherapy for malignant brain tumors, we have been investigating heating techniques using a re-entrant type applicator, which is a noninvasive heating apparatus.
In 2001, we conducted experiments to control the extent of heating. By making some improvements to the trial apparatus and changing the diameter of the re-entrant area, we were able to confirm that the extent of heating can be controlled to a maximum of about 80% of the heated tissue.
In 2002, while aiming for clinical use, a round window for inserting patients was placed on the lateral side of the re-entrant type applicator with a diameter of 120 cm and height of 120 cm that had been developed for research use. Initially, using three-dimensional computer simulation, we confirmed that electric field leakage to the outside area was below the allowance. We then measured electric field leakage using a phantom. We were able to confirm that the electric field was within the allowance at least 50
… More
cm away from the window. This finding was presented at The 19th Annual Meeting of the Japanese Society of Hyperthermic Oncology.
Furthermore, a phantom in the shape of a human body was heated, and the distribution of temperature was measured by infrared thermography. When thermotherapy was conducted at 30 W for 15 minutes, the temperature at the core of the phantom increased by 4.5 degrees, while that at the surrounding area was less than 2 degrees, and no problematic hot spot was seen. This finding was presented at The Annual Meeting of Denshi-johotsushin at Shinetsushibu.
In an animal study, a beagle was inserted through the round window on the side of the re-entrant type applicator. Electric field leakage was also below the allowance at least 50 cm away from the window.
If re-entrant type thermotherapy is applied clinically, thermotherapy can be repeatedly performed in a noninvasive manner, thus increasing the efficacy of thermotherapy. Noninvasive thermotherapy in the head region using a re-entrant type applicator appears to be promising, and it should be clinically useful. Less
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Research Products
(8 results)
