2003 Fiscal Year Final Research Report Summary
Studies on origin and coevolution of Schistosoma japonicum in Asia
| Project/Area Number |
13576008
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
寄生虫学(含医用動物学)
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| Research Institution | Kochi Medical School |
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Principal Investigator |
AGATSUMA Takeshi Kochi University, Kochi Medical School, Professor, 医学部, 教授 (40117031)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Masaaki Nagasaki University, Institute of Tropical Medicine, 熱帯医学研究所, 教授 (70124831)
HIRAI Hirosisa Kyoto University, Primate Research Institute, 霊長類研究所, 助教授 (10128308)
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| Project Period (FY) |
2001 – 2003
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| Keywords | Schistosomatidae / Schistosoma / Orientobilharzia / avian schistosome / mammalian schistosome / molecular phylogenetic tree / origin of Schistosoma / Coevolution |
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| Research Abstract |
To date, in order to examine the origin of the genus Schistosoma, phylogenetic relationships among the genus Schistosoma have been estimated using partial nucleotide sequences of CO1, 1srDNA and ITS2. In this study, whole nucleotide sequences of CO1, 1srDNA aqnd ssrDNA were determined for the first time, and on the basis of the sequence information, phylogenetic relationships were inferred among species from the family Schistosomatidae. Materials used in this study are in total 29 species in 10 genera consisting of 6 genera from the subfamily Schistosomatinae, two genera from the subfamily Bilharziellinae and two genera from the subfamily Gigantobilharziinae. The genus Chimaerohemecus in the family Sanguinicolidae was used as an outgroup. The number of nucleotides determined for CO1, ssrDNR and 1srDNA was 1122 bp and 3765 bp, respectively. In this study, combined nuleotide sequences including all of the three genes were used for tree analysis. It was estimated that the mammalianschistosomes were paraphyletic, since the clad of (Ornithobilharzia+Austrobilharzia) was supported to be a sister clad of (Schistosoma+Orientobilharzia). It was also found that Orientobilharzia was placed within the genus Schistosoma, and a sister of clad consisting of the African group and the S.indicum group. This result suggests that Orientobilharzia could be an ancestral species for them.
There are two theories on the origin of Schistosoma. One is the African origin theory by Davis (1980,1992), proposing that Indian continental plate, which separated from the Gondwana Land, carried an ancestral species of Schistosoma from Africa to Asia. Another is the Asian origin theory (Snyder & Loker,2000; Agatsma et al., 2003; Locker et al., 2004) proposing that an ancestral species of Schistosoma occurred in Asia and expanded Asia to Africa through migration of a mammalian host. The present study supported the Asian origin theory again.
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Research Products
(19 results)
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[Journal Article] Phylogenetic relationships of snail hosts of the genera Oncomelania and Tricula inferred from the mitochondrial 12S RNA gene.2003
Author(s)
M.Okamoto, C.T.Lo, W.U.Tiu, D.Qui, P.Hadidjaja, E.S.Upatham, H.Sugiyama, T.Taguchi, H.Hirai, Y.Saitoh, S.Habe, M.Kawanaka, M.Hirata, T.Agatsuma
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Journal Title
Japanese Journal of Tropical Medicine and Hygiene 31
Pages: 5-10
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The phylogeny of the Schistosomatidae based on three genes with emphasis on the interrelationships of Schhistosoma Weinland, 1858.2003
Author(s)
A.E.Lockyer, P.D.Olson, P.Stergaard, D.Rollinson, D.A.Johnston, S.W.Attwood, V.R.Southgate, P.Horak, S.D.Snyder, T.H.Le, T.Agatsuma, D.P.McManus, A.C.Carmichael, S.Naem, D.T.J.Littlewood
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Journal Title
Parasitology 126
Pages: 203-224
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Affinities between Asian non-human Schistosoma species,the S. indicum group,and the African human schistosomes.2002
Author(s)
T.agatsuma, M.Iwagami, C.X.Liu, R.P.V.J.Rajapakse, M.Mondal, V.Kitikoon, S.Ambu, Y.Agatsuma, D.Blair, T.Higuchi
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Journal Title
Journal of Helminithology 76
Pages: 7-19
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Affinities between Asian non-human Schistosoma species, the S.indicum group, and the African human schistosomes.2002
Author(s)
T.Agatsuma, M.Iwagami, C.S.Liu, R.P.V.J.Rajapakse, M.Mondal, V.Kitikoon, S.Ambu, Y.Agatsuma, D.Blair, T.Higuchi
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Journal Title
Journal of Helminthology 76
Pages: 7-19
Description
「研究成果報告書概要(欧文)」より
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