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2003 Fiscal Year Final Research Report Summary

International collaboration study on health effects and safety use of pesticides.

Research Project

Project/Area Number 13576019
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Public health/Health science
Research InstitutionMie University (2003)
The University of Tokyo (2001-2002)

Principal Investigator

YOKOYAMA Kazuhito  Mie University, Faculty of Medicine, Professor, 医学部, 教授 (00158370)

Co-Investigator(Kenkyū-buntansha) KITAMURA Fumihiko  National Institute of Industrial Health, Researcher, 研究員 (20301145)
PIAO Feng yuan  Mie University, Faculty of Medicine, Associate Professor, 医学部, 講師 (50283528)
ISHIKAWA Hitosi  Mie University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (50250915)
ARAKI Shunichi  National Institute of Industrial Health, President, 理事長(研究職) (00111493)
Project Period (FY) 2001 – 2003
KeywordsPesticide / Health effects / Malaysia / Tobacco growing / Nervous system function / Epidemiology / Nicotine poisoning / Green tobacco sickness
Research Abstract

Few epidemiological studies have been conducted on the effects of pesticides on neurobehavioral function in human populations. The present study was aimed at elucidating (1) subclinical neurobehavioral effects of pesticides, (2) relationships between these effects and safety use, and (3) factors influencing safety behavior among tobacco farmers in Kelatntan, Malaysia. The study was carried out under the collaboration with Professor Rusli Bin Nordin, Universiti Sains Malaysia. Surveys using neurobehavioral and neurolectrophysiological tests and questionnaires were conducted together with biological monitoring of exposures, i.e. analyses of pesticides and their metabolites in serum and urine as well as measurement of serum cholinesterase activities. Furthermore, effects of nicotine absorbed from green tobacco leaves were examined. It was observed that pesticide absorption caused neuroelectrophysiological effects and subjective symptoms, which were related to safety behaviors such as use of personal protective equipments. Green Tobacco Sickness due to nicotine absorption was also demonstrated in the farmers.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Yokoyama, K.: "Computerized posturography with sway frequency analysis : application in occupational and environmental health"Industrial Health. 40. 14-22 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yokoyama, K.: "Subclinical cerebellar anterior lobe, vestibule-cerebellar and spinocerebellar afferente effects in young female lead workers in China : computerized posturography with sway frequency analysis and brainstem auditory evoked potentials."Industrial Health. 40. 245-253 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ueno, S.: "Effects of pH and temperature on force and stiffness of skeletal muscle fibers during contraction and relaxation in relation to musculoskeletal disorders."Industrial Health. 40. 362-369 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Rusli, B.N.: "Effects of safety behaviours with pesticide use on occurrence of acute symptoms in male and female tobacco-growing Malaysian farmers."Industrial Health. 40. 182-190 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitamura, F.: "Increase of olfactory threshold in planting factory workers exposed to chromium in Korea"Industrial Health. 41. 279-285 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Onuki, M: "Assessment of urinary cotinine as a marker of nicotine absorption from tobacco leaves : a study on tobacco farmers in Malaysia."Journal of Occupational Health. 45. 140-145 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Piao, F.: "Subacute toxic effects of zinc on various tissues and organs of rats."Toxicology Letters. 145. 28-35 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Vigeh, M.: "Increased blood lead in pregnancy hypertension in women without occupational lead exposure, Tehran, Iran."Archives of Environmental Health. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yokoyama, K.: "Computerized posturography with sway frequency analysis : application in occupational and environmental health."Industrial Health. 40. 14-22 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yokoyama, K.: "Subclinical cerebellar anterior lobe, vestibule-cerebellar and spinocerebellar afferent effects in young female lead workers in China : computerized posturography with sway frequency analysis and brainstem auditory evoked potentials."Industrial Health. 40. 245-253 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ueno, S.: "Effects of pH and temperature on force and stiffness of skeletal muscle fibers during contraction and relaxation in relation to musculoskeletal disorders."Industrial Health. 40. 362-369 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Rusli, B.N.: "Effects of safety behaviours with pesticide use on occurrence of acute symptoms in male and female tobacco-growing Malaysian farmers."Industrial Health. 40. 182-190 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitamura, F.: "Increase of olfactory threshold in planting factory workers exposed to chromium in Korea."Industrial Health. 41. 279-285 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Onuki, M.: "Assessment of urinary cotinine as a marker of nicotine absorption from tobacco leaves : a study on tobacco farmers in Malaysia."Journal of Occupational Health. 45. 140-145 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Piao, F.: "Subacute toxic effects of zinc on various tissues and organs of rats."Toxicology Letters. 145. 28-35 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Vigeh, M.: "Increased blood lead in pregnancy hypertension in women without occupational lead exposure, Tehran, Iran"Archives of Environmental Health. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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