2002 Fiscal Year Final Research Report Summary
Risk Factors for Asian Thrombophilia
| Project/Area Number |
13576031
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
HAMASAKI Naotaka Graduate School of Medical Sciences Department of Clinical Chemistry and Laboratory Medicine Professor and Director, 医学研究院, 教授 (00091265)
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| Co-Investigator(Kenkyū-buntansha) |
MUTA Koichiro Kyushu University Hospital Department of Internal Medicine Assistant Professor, 医学部附属病院, 助手 (50229928)
ISHIBASHI Tatsuro Graduate School of Medical Sciences Department of Ophthalmology Professor and Director, 医学研究院, 教授 (30150428)
KANG Dongchon Graduate School of Medical Sciences Department of Clinical Chemistry and Laboratory Medicine Associate Professor, 医学研究院, 助教授 (80214716)
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| Project Period (FY) |
2001 – 2002
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| Keywords | thrombophilia / Prolein S / polymorphism / gene analysis / tertiary structure of protein S |
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| Research Abstract |
Although the constitutional background of Japanese thrombotic patients has not been well examined, coagulation factor V Leiden is not detected in Japanese patients suffering from thromboses. We have been investigating constitutional predispositions of patients suffering from deep vein thrombosis in the Japanese population. In the present study, we summarize our results of Japanese patients suffering from deep vein thrombosis.
A surprisingly high frequency of Japanese patients suffering from deep vein thrombosis have reduced activity in the protein S/protein C anticoagulation system. Reduced activity in the protein S/protein C anticoagulation system was observed in 58% patients with deep vein thrombosis, while reduced activity of antithrombin was noted in 7% patients, a level consistent with the frequency in Caucasian patients. Gene analyses were performed on the factors associated with patients having reduced activities (10-12). Nineteen patients had mutated protein S genes, including 5 patients having protein S_<Tokushima>(K155E), 8 patients had mutated protein C genes, and two patients had mutated antithrombin genes.
Our study indicates that the frequency of inherited protein S abnormalities in Japanese patients suffering from deep vein thrombosis is significantly high, ten times higher than the frequency in Caucasian patients, and that abnormality of the protein S/protein C anticoagulation system is a major risk factor for deep vein thrombosis in Japan. It is interesting to note that the frequency of factor V Leiden in Caucasian deep vein thrombosis patients is similar to that of gene mutations of the protein S/protein C anticoagulalion system in Japanese deep vein thrombosis patients.
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[Publications] Suematsu N, Tsutsui H, Wen J, Kang D, Ikeuchi M, Ide T, Hayashidani S, Shiomi T, Kubota T, Hamasaki N, Takeshita A: "Oxidative Stress Mediates Tumor Necrosis Factor-_-Induced Mitochondrial DNA Damage and Dysfunction in Cardiac Myocytes"Circulation. 107. 1418-1423 (2003)
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