2002 Fiscal Year Final Research Report Summary
Studies on neuroendocrinological mechanisms of memory in the Hatano rats
| Project/Area Number |
13660296
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
TAYA Kazuyoshi Tokyo University of Agriculture aud Technology, Faculty of Agriculture, Professor, 農学部, 教授 (60092491)
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| Co-Investigator(Kenkyū-buntansha) |
SHIROTA Mariko Hatano Research Institute, Food and Drug Safety Center, Researcher, 秦野研究所, 研究員
OHTA Ryo Hatano Research Institute, Food and Drug Safety Center, Researcher, 秦野研究所, 研究員
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| Project Period (FY) |
2001 – 2002
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| Keywords | Hatano rats / avoidance learning / inhibin / stress response / ACTH / prolactin / corticosterone / FSH |
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| Research Abstract |
Hatano high avoidance (HAA) and low avoidance (LAA) strains rats have been originally selected and bred from Sprague-Dawley rats for their shuttle-box task. The present study focused on the activity of the hypothalamo-pituitary-adrenocortical axis (HPA) of HAA and LAA rats in response to restraint stress. The restraint stress induced an elevation of plasma concentrations of ACTH, prolactin, corticosterone and progesterone, and in adrenal concentrations of coricosterone and progesterone. Peak levels of plasma ACTH during stress condition were significantly higher in HAA rats than LAA rats, while peak levels of prolactin were significantly lower in HAA rats than LAA rats. ACTH and prolactin syntheses in anterior pituitary glands were significantly higher in HAA rat than LAA rats during stress. The plasma concectrations of corticosterone, as shown bv percentage of initial values, during stress were significantly higher in HAA rats than LAA rats. Adrenal concentrations of corticosterone and progesterone increased during stress in both strains, although no significant strain deference was observed between HAA and LAA. These results indicate that the activities of HPA axis to acute restraint stress are higher in HAA rats than LAA rats, whereas prolactin secretory activity is vice versa. These endocrine differences in response to stress may be involved in regulation of memory.
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Research Products
(12 results)
