2002 Fiscal Year Final Research Report Summary
Analysis of involvement of prolactin releasing peptides in modulating excitability of oxytocin cells
| Project/Area Number |
13670057
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Fukui Medical University |
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Principal Investigator |
HONDA Kazumasa Fukui Med. Sch. Faculty of Medicine, Associate Prof., 医学部, 助教授 (50143946)
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| Co-Investigator(Kenkyū-buntansha) |
NARITA Kazumi Fukui Med. Sch. Faculty of Medicine, Res. Associate, 医学部, 助手 (80270958)
MURATA Takuya Fukui Med. Sch. Faculty of Medicine, Res. Associate, 医学部, 助手 (70281186)
HIGUCHI Tahashi Fukui Med. Sch. Faculty of Medicine, Prof., 医学部, 教授 (70106326)
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| Project Period (FY) |
2001 – 2002
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| Keywords | milk-ejection reflex / oxytocin cell / prolactin-releasing peptide / supraoptic nucleus / hypothalamus / rat |
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| Research Abstract |
The hypothalamic dorsomedial nucleus (DMH) is suggested to be a final relay site for the afferent of milk-ejection reflex (MER) [1]. Existence of prolactin releasing peptide (PrRP) - immunoreactive cells [2] and cells expressing PrRP-mRNA[3] in the DMH and synaptic contact of PrRP-IR terminals with oxytocin (OT) cells was reported [2]. It was also shown that intracerebroventricular injection of PrRP stimulated oxytocin release in rats[4]. Experiments were done to test the effect of PrRP on the electrical activity of OT cells in the supraoptic nucleus (SON). In rat hypothalamic slice preparations containing supraoptic nucleus, OT cells were unresponsive to peptides. In lactating rats, whereas lateral ventricular (LV) injection of PrRP (20-30 nmol) were ineffective, a hundred nmol of the peptide increased basal activity and amplitude of bursting activities of oxytocin cells. Cells responded to LV injection of PrRP were unresponsive to direct application of the peptide by pressure ejection from the recording electrode. Results suggest that PrRP may modulate activity of OT cells through its action on the area other than SON.
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Research Products
(6 results)
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[Publications] Maruyama M, Matsumoto H, Fujiwara K, Noguchi J, Kitada C, Hinuma S, Onda H, Nishimura O, Fujino M, Higuchi T, Inoue K: "Central administration of prolactin-releasing peptide stimulates oxytocin release in rats"Neurosci.Lett. 276(3). 193-196 (1999)
Description
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