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2002 Fiscal Year Final Research Report Summary

Development of a positron-sensitive probe for tumor detection

Research Project

Project/Area Number 13670974
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKobe City College of Technology

Principal Investigator

YAMAMOTO Seiichi  Kobe City College of Technology, Electrical Engineering, Professor, 電気工学科, 教授 (00290768)

Co-Investigator(Kenkyū-buntansha) ITO Masatoshi  Tohoku University, Cyclotron Radio-isotope Center, Professor, サイクロトロンRIセンター, 教授 (00125501)
Project Period (FY) 2001 – 2002
Keywordspositron / Radio-guided surgery / F-18-FDG / Annihilation gamma photons / Background counts / Spatial resolution / Sensitivity / Count rate characteristics
Research Abstract

For radio-guided surgery on tumors using F-18-FDG, detection of annihilation gamma photons emanating from other parts of the body produces background radiation counts and limits its use in clinical situations. To overcome this limitation, we have developed an intra-operative positron probe with background-rejection capability. The positron probe uses a phoswich detector composed of a plastic scintillator and a bismuth germinate (BGO). A positron from a positron emitter such as F-18 is detected by the plastic scintillator and emits annihilation photons. The BGO detects one of the annihilation photons while a photo-multiplier tube (PMT) detects scintillation photons from both scintillators. The decay time differences of these two scintillators are used to distinguish whether the event is a true event where a positron, and a following annihilation photon are detected simultaneously, or a background event. In this configuration, only positrons can be selectively detected, even in an environment of high background gamma photon flux. Spatial resolution was 11-mm full width at half maximum (FWHM) 5 mm from the detector surface. Measured sensitivity for the F-18 point source was 2.6 cps/kBq 5 mm from the detector surface. The background count rate was less than 0.5cps for a 20-cm diameter cylindrical phantom containing 37 MBq of F-18 solution measured on the phantom surface, while the positron count rate was almost linear over a range of approximately 6 kcps. These results indicate that our developed intra-operative positron probe is valuable for radio-guided surgery on tumors using F-18-FDG in a high flux of background annihilation gamma photons.

  • Research Products

    (8 results)

All 2005 2004 2002 2001

All Journal Article (8 results)

  • [Journal Article] An intra-operative positron probe with background rejection capability2005

    • Author(s)
      Seiichi Yamamoto, et al.
    • Journal Title

      Annals of Nuclear Medicine Vil.29,No.1

      Pages: 23-28

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] An intra-operative positron probe with background rejection capability2005

    • Author(s)
      Seiichi Yamamoto, Kenichi Matsumoto, Setu Sakamoto, Kazumasa Tarutani, Kotaro Minato, Michio Senda
    • Journal Title

      Annals of Nuclear Medicine Vol.18, No.3

      Pages: 252-256

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Optimum threshold setting for a positron-sensitive probe with background rejection capability2004

    • Author(s)
      Seiichi Yamamoto, et al.
    • Journal Title

      Annals of Nuclear Medicine Vol.18,No.3

      Pages: 252-256

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Optimum threshold setting for a positron-sensitive probe with back-ground rejection capability2004

    • Author(s)
      Seiichi Yamamoto, Kenichi Matsumoto, Michio Senda
    • Journal Title

      Annals of Nuclear Medicine Vol.18, No.3

      Pages: 252-256

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Development of a positron intra-operative probe with background Rejection capability2002

    • Author(s)
      Seiichi Yamamoto, et al.
    • Journal Title

      Journal of Nuclear Medicine Vol.43,No.3

      Pages: 60

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Development of a positron intra-operative probe with background rejection capability2002

    • Author(s)
      Seiichi Yamamoto, Kenichi Matsumoto, Setu Sakamoto, Michio Senda
    • Journal Title

      Journal of Nuclear Medicine Vol.43, No.3

      Pages: 60

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] ノイズ除去機構を有するポジトロン術中プローブの開発2001

    • Author(s)
      山本誠一, 垂谷一正 他
    • Journal Title

      核医学 第38巻第5号

      Pages: 547

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 核医学用検出器2001

    • Author(s)
      山本誠一
    • Journal Title

      核医学 第38巻第5号

      Pages: 494

    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2006-07-11  

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