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2002 Fiscal Year Final Research Report Summary

Basic studies on the maintenance therapy of schizophrenia with atypical antipsychoticsl

Research Project

Project/Area Number 13671010
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Tokushima

Principal Investigator

OHMORI Tetsuo  University of Tokushima. SCHOOL OF MEDICINE Professor, 医学部, 教授 (00221135)

Co-Investigator(Kenkyū-buntansha) KANEDA Yasuhiro  University of Tokushima. UNIVERSITY HOSPITAL Assistant Professor, 医学部附属病院, 助手 (70325281)
Project Period (FY) 2001 – 2002
KeywordsSchizophrenia / Methamphetamine / Sensitization / Clozapine / Acetyicholine / Glutamate / GABA / Atypical neuroleptics
Research Abstract

Repeated administration of methamphetamine results in schizophrenia-like psychosis in human and behavioral senslization in animals. Understanding of behavioral senslization may provide insight into the pathogenesis of both methamphetamine-induced psychosis and schizophrenia. It has been shown that NMDA antagonists block the development of sensitization, suggesting a role of glutamete in the phenomenon. In our previous project, we found that central cholinergic receptor and central phenomenon. In our previous project, we found that central cholinergic receptors and central GABA-benzodiazepine receptors also play an important role in the development of behavioral sensitization. In the present study, we showed that nitric oxide synthesis inhibition blocks the neurotoxicity induced by high doses of methamphetamine. These results as well as our previous results suggest that a neuronal circuit involving dopaminergic, cholinergic and GABAnergic pathways play an important role in the development of dehavioral sensitization.
Clozapine, a prototypical atypical neuroleptic, is a week dopamine d2 receptor blocker, but has many site of action and interfere with glutamatergic, cholinergic and GABAnergic function. Thus, it is assumed that the drug can blocks the development of sensitization by acting vatious sites in the neuronal circuit responsible for development of the phenomenon. Clinical studies on some other atypical neuroleptics were also conducted.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Kaneda Y.: "The hypothalamic-pituitary-adrenal axis in chronic schizophrenic patients long-term treated with neuroleptics"Progress in Neuro-Psychopharmacology & Biological Psychiatry. 26. 935-938 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaneda Y.: "Schizophrenia Quality of Life Scale : validation of the Japanese version"Psychiatry Res.. Dec. 15:113(1-2). 107-113 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaneda Y, Kawamura I, Fujii A, Ohmori T: "Quetiapine therapy in treatment-refractory schizophrenia"German J Psychiatry. 4. 63-67 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tetsuro Ohmori: "The potential role of atypical neuroleptics in the maintence treatment of schizophrenia"Psychiat Neurol. Jap. 103. 470-475 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Abekawa T, Ohmori T, Honda M, Ito K, Koyama T: "Effect of low doses of L-NAME on methamphetamine-induced dopaminergic depletion in the rat striatum"J Neural Transm. 108(11). 1219-1230 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Abekawa T, Ohmori T, Honda M, Ito K Koyama T: "Behavioral change and molecular biology in the methamphetmine sensitization"Jon Molecular Psychiatry. 2. 46-54 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaneda Y, Fujii A, Ohmori T: "The hypothalamic-pictuitary-adrenal axis in chromic schizophrenic patients long-term treated with neuroleptics"Prog Neuro-Psychopharmacol & Biol Psychiat. 26. 935-938 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaneda Y, Imakura A, Fujii A, Ohmori T: "Shizophrenia Quality of Life Scale: validation of the Japanese version"Psychiatry Res. 113. 107-113 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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