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2002 Fiscal Year Final Research Report Summary

Remission of Graves' Hyperthyroidism and CTLA-4-Gene

Research Project

Project/Area Number 13671159
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionUniversity of the Ryukyus

Principal Investigator

TAKASU Nobuyuki  University of the Ryukyus, Department of Medicine, Professor, 医学部, 教授 (20020927)

Co-Investigator(Kenkyū-buntansha) KOUKI Tuyoshi  University of the Ryukyus, Department of Medicine, Instructor, 医学部附属病院, 助手 (80273415)
SHIMABUKURO Michio  University of the Ryukyus, Department of Medicine, Assistant Professor, 医学部附属病院, 講師 (60271144)
Project Period (FY) 2001 – 2002
KeywordsGraves' disease / Hyperthyroidism / Remission / CTLA-4 / TSAb (thyroid stimulating Ab) / TRAb (TSH receptor Ab) / CTLA-4遺伝子多型 / 放射線療法
Research Abstract

We studied whether a patient with Graves' disease will go into remission during antithyroid drug (ATD) treatment. Remission of Graves' hyperthyroidism is predicted by a smooth decrease in TSH receptor antibody (TRAb) during ATD treatment. Cytotoxic T cell lymphocyte-associated molecule-4 (CTLA-4) may play an important role in the development of Graves' hyperthyroidism and in its remission. We studied A/G polymorphism at position 49 in exon 1 of the CTLA-gene in Japanese Graves' patients. We revealed the association of CTLA-4 polymorphism with remission of Graves' hyperthyroidism.

  • Research Products

    (48 results)

All Other

All Publications (48 results)

  • [Publications] Kinjyo Y, Takasu N, et al.: "Remission of Graves' Hyperthyroidism and A/G Polymorphism at Position 49 in Exon 1 of Cytotoxic T Lymphocyte Associated Molecule-4 (CTLA-4) Gene"J Clin Endocrinol Metab. 87(6). 2593-2596 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tomoyose T, Takasu N, et al.: "Cytotoxic T-lymphocyte antigen-4 gene polymorphisms and human T-cell lymphotrophic virus-1 infection : their associations with Hashimoto's thyroiditis in Japanese patients"Thyroid. 12(8). 673-677 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ochi Y, Takasu N, et al.: "Sensitive thyroid stimulating antibody (TSAb) assay using polyethylene glycol (PEG)--a review"J Immunoassay Immunochem. 23(4). 461-470 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikema T, Takasu N, et al.: "Identification of three new mutations of the HNF-1 alpha gene in Japanese MODY families"Diabetologia. 45(12). 1713-1718 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamakaw K: "Galpha 13 induces preproET-1 gene expression via JNK"Hypertens Res 2002. 25(3). 427-432 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyagi J, Takasu N, et al.: "Acute myeloid leukemia (FAB-M2) with a masked type of t(8;21) translocation revealed by spectral karyotyping"Int J Hematol. 76(4). 338-343 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyagi J, Takasu N, et al.: "Establishment of a primary effusion lymphoma cell line (RN-P1) and in vivo growth system using SCID mice"Int J Hematol. 76(2). 165-172 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takasu N, et al.: "TSBAb (TSH-stimulation blocking antibody) and TSAb (thyroid stimulating antibody) in TSBAb-positive patients with hypothyroidism and Graves' patients with hyperthyroidism"Horm Metab Res. 33(4). 232-237 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takasu N, et al.: "Remission of Graves' hyperthyroidism predicted by smooth decreases of thyroid-stimulating antibody and thyrotropin-binding inhibitory immunoglobulin during antithyroid drug treatment"Thyroid. 10(10). 891-896 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Asahi T, Takasu N, et al.: "Cilazapril prevents cardiac hypertrophy and postischemic myocardial dysfunction in hyperthyroid rats"Thyroid. 11(11). 1009-1015 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsushita M, Takasu N, et al.: "Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues"J Hypertens. 19(12). 2185-2190 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ochi Y, Takasu N, et al.: "Sensitive assay to detect thyroid stimulating antibody (TSAb) in the presence of thyroid stimulating blocking antibody (TSBAb) in serum"Horm Metab Res. 33(2). 115-120 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oshiro Y, Takasu N, et al.: "Triiodothyronine concomitantly inhibits calcium overload and postischemic myocardial stunning in diabetic rats"Life Sci. 69(16). 1907-1918 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohshiro Y, Takasu N, et al.: "Analysis of 825C/T polymorphism of G proteinbeta3 subunit in obese/diabetic Japanese"Biochem Biophys Res Commun. 286(4). 678-680 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugimoto J, Takasu N, et al.: "Transcriptionally active HERV-K genes : identification, isolation, and chromosomal mapping"Genomics. 72(2). 1137-1144 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyagi J, Takasu N et al.: "Detection of Epstein-Barr virus and human T-cell lymphotropic virus type 1 in malignant nodal lymphoma, studied in Okinawa, a subtropical area in Japan"Int J Hematol. 75(1). 78-84 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Higa M, Takasu N, et al.: "Atrophic change of rat salivary gland during adenovirus-induced hyperleptinemia"Biochem Biophys Res Commun. 291(3). 675-679 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyagi J, Takasu N, et al.: "Increased risk of human herpesvirus-8 infection in patients with adult T cell leukemia/lymphoma in Okinawa"Leukemia. 16(9). 1881-1882 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukuchi M, Takasu N, et al.: "Evidence for a deficient pancreatic beta-cell response in a rat model of hyperthyroidism"Life Sci. 71(9). 1059-1070 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohshiro Y, Takasu N, et al.: "Sequence analysis of the pro-opiomelanocortin (POMC) gene in obese/diabetic Japanese"Int J Obes Relat Metab Disord. 26(5). 730-731 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kinjo Y, Takasu N, et al.: "Identification of nonsynonymous polymorphisms in the superantigen-coding region of IDDMK1,2 22 and a pilot study on the association between IDDMK1,2 22 and type 1 diabetes"J Hum Genet. 46(12). 712-716 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Komiya I, Takasu N, et al.: "Remission and recurrence of hyperthyroid Graves' disease during and after methimazole treatment when assessed by IgE and interleukin 13"H Clin Endocrinol Metab. 86(8). 3540-3544 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimajiri Y, Takasu N, et al.: "A missense mutation of Pax4 gene (R121W) is associated with type 2 diabetes in Japanese"Diabetes. 50(12). 2864-2869 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 高須 信行: "バセドウ病以外の甲状腺機能亢進症・甲状腺中毒症"日野原重明, 井村裕夫 監修 「最新医学講座---代謝疾患・内分泌疾患」、中山書店、東京. 305-312 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kinjo Y, Matsuura N, Yokota Y, Ohtsu S, Nomoto K, Komiya I, Sugimoto J, Jinno Y, Takasu N: "Identification of nonsynonymous polymorphisms in the superantigen-coding region of IDDMK1,2 22 and a pilot study on the association between IDDMK1,2 22 and type 1 diabetes"J Hum Genet. 46. 712-716 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asahi T, Shimabukuro M, Oshiro Y, Yoshida H, Takasu N: "Cilazapril prevents cardiac hypertrophy and postischemic myocardial dysfunction in hyperthyroid rats"Thyroid. 11. 1009-1015 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsushita M, Shichiri M, Imai T, Iwashina M, Tanaka H, Takasu N, Hirata Y: "Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues"J Hypertens. 19. 2185-2190 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimajiri Y, Sanke T, Furuta H, Hanabusa T, Nakagawa T, Fujitani Y, Kajimoto Y, Takasu N, Nanjo K: "A missense mutation of Pax4 gene (R121W) is associated with type 2 diabetes in Japanese"Diabetes. 50. 2864-2869 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oshiro Y, Shimabukuro M, Takasu N, Asahi T, Komiya I, Yoshida H: "Triiodothyronine concomitantly inhibits calcium overload and postischemic myocardial stunning in diabetic rats"Life Sci. 69. 1907-1918 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohshiro Y, Ueda K, Wakasaki H, Takasu N, Nanjo K: "Analysis of 825C/T polymorphism of G proteinbeta3 subunit in obese/diabetic Japanese"Biochem Biophys Res Commun. 286. 678-680 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Komiya I, Yamada T, Sato A, Kouki T, Nishimori T, Takasu N: "Remission and recurrence of hyperthyroid Graves' disease during and after methimazole treatment when assessed by IgE and interleukin 13"J Clin Endocrinol Metab. 86. 3540-3544 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugimoto J, Matsuura N, Kinjo Y, Takasu N, Oda T, Jinno Y: "Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping"Geonomics. 72. 137-144 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takasu N, Yamashiro K, Ochi Y, Sato Y, Nagata A, Komiya I, Yoshimura H: "TSBAb (TSH-stimulation blocking antibody) and TSAb (thyroid stimulating antibody) in TSBAb-positive patients with hypothyroidism and Graves' patients with hyperthyroidism"Horm Metab Res. 33. 232-237 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ochi Y, Yamashiro K, Takasu N, Kajita Y, Sato Y, Nagata A: "Sensitive assay to detect thyroid stimulating antibody (TSAb) in the presence of thyroid stimulation blocking antibody (TSBAb) in serum"Horm Metab Res. 33. 115-120 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Higa M, Shimabukuro M, Fukuchi M, Komiya I, Takasu N: "Atrophic change of rat salivary gland during adenovirus-induced hyperleptinemia"Biochem Biophys Res Commun. 291. 675-679 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikema T, Shimajiri Y, Komiya I, Tawata M, Sunakawa S, Yogi H, Shimabukuro M, Takasu N: "Identification of three new mutations of the HNF-1 alpha gene in Japanese MODY families"Diabetologia. 45. 1713-1718 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tomoyose T, Komiya I, Takara M, Yabiku K, Kinjo Y, Shimajiri Y, Yogi H, Kouki T, Masuda M, Takasu N: "Cytotoxic T-lymphocyte antigen-4 gene polymorphisms and human T-cell lymphotropic virus-1 infection: their associations with Hashimoto's thyroiditis in Japanese patients"Thyroid. 12. 673-677 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kinjo Y, Takasu N, Komiya I, Tomoyose T, Takara M, Kouki T, Shimajiri Y, Yabiku K, Yoshimura H: "Remission of Graves' hyperthyroidism and A/G polymorphism at position 49 in exon 1 of cytotoxic T lymphocyte-associated molecule-4 gene"J Clin Endocrinol Metab. 87. 2593-2596 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukuchi M, Shimabukuro M, Shimajiri Y, Oshiro Y, Higa M, Akamine H, Komiya I, Takasu N: "Evidence for a deficient pancreatic beta-cell response in a rat model of hyperthyroidism"Life Sci. 71. 1059-1070 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamakawa K, Kitamura K, Nonoguchi H, Takasu N, Miller RT, Tomita K: "Galpha13 induces preproET-1 gene expression via JNK"Hypertens Res. 25. 427-432 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ochi Y, Takasu N: "Sensitive thyroid stimulating antibody (TSAb) assay using polyethylene glycol (PEG) - a review"J Immunoassay Immunochem. 23. 461-470 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohshiro Y, Ueda K, Wakasaki H, Kosaka M, Nishi M, Sasaki H, Takasu N, Nanjo K: "Sequence analysis of the pro-opiomelanocortin (POMC) gene in obese/diabetic Japanese"Int J Obes. 26. 730-731 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyagi J, Toda T, Uezato H, Ohshima K, Miyakuni T, Takasu N, Masuda M: "Detection of Epstein-Barr virus and human T-cell lymphotropic virus type 1 in malignant nodal lymphoma, studied in Okinawa, a subtropical area in Japan"Int J Hematol. 75. 78-84 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyagi J, Masuda M, Takasu N, Nagasaki A, Shinjyo T, Uezato H, Kakazu N, Tanaka Y: "Establishment of a primary effusion lymphoma cell line (RM-P1) and in vivo growth system using SCID mice"Int J Hematol. 76. 165-172 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyagi J, Kakazu N, Masuda M, Miyagi T, Toyohama T, Nakazato T, Tomoyose T, Shinjyo T, Nagasaki A, Taira N, Ohki M, Abe T, Takasu N: "Acute myeloid leukemia (FAB-M2) with a masked type of t(8;21) translocation revealed by spectral karyotyping"Int J Hematol. 76. 338-343 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyagi J, Masuda M, Uezato H, Sawada T, Miyakuni T, Miyoshi I, Takasu N: "Increased risk of human herpesvirus-8 infection in patients with adult T cell leukemia/lymphoma in Okinawa"Leukemia. 16. 1881-1882 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsushita M, Shichiri M, Fukai N, Ozawa N, Yoshimoto T, Takasu N, Hirata Y: "Urotensin II is an Autocrine/Paracrine Growth Factor for the Porcine Renal Epithelial Cell Line, LLCPK1"Endocrinology. 144(5). 1825-1831 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimajiri Y, Shimabukuro M, Tomoyose T, Yogi H, Komiya I, Takasu N: "PAX4 mutation (R121W) as a prodiabetic variant in Okinawans"Biochem Biophys Res Commun. 302(2). 342-344 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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