2002 Fiscal Year Final Research Report Summary
Basic research for the establishment of anti-angiogenic therapy by antibody to VEGF
| Project/Area Number |
13671288
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
TAKAHASHI Yutaka Cancer Research Institute, Kanazawa University Associate Professor, がん研究所, 助教授 (10179541)
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| Project Period (FY) |
2001 – 2002
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| Keywords | Angiogenesis / VEGF / Liver metastasis |
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| Research Abstract |
I examined the effect of antibody to VEGF on two cell lines, KKLS and KM12sm : I have previously reported that VEGF upregulated in the orthotopic implantation of KKLS, and bFGF did in that of KM12sm. Antibody to VEGF inhibited the liver metastasis of KKLS, while did not that of KM12sm. Moreover, mRNA of other angiogenic factors such as bFGF did not upregulate in KKLS after therapy of antibody to VEGF therapy.
From these results, it is suggested that antibody to VEGF should be given to the tumor whose VEGF upregulated and we can give it for a long time.
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