2002 Fiscal Year Final Research Report Summary

Monoclonal Antibody A7 Coupled to Magnetic Particles as a Contrast

Research Project

Project/Area Number	13671327
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Digestive surgery
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	OTSUJI Eigo Kyoto Prefectural University of Medicine, School of Medicine, Department of Surgery, Assistant Professor, 医学部, 講師 (20244600)
Co-Investigator(Kenkyū-buntansha)	OKAMOTO Kazuma Kyoto Prefectural University of Medicine, School of Medicine, Department of Surgery, Assistant Professor, 医学部, 助手 (20285258)
Project Period (FY)	2001 – 2002
Keywords	MONOCLONAL / ANTIBODY / A7 / PANCREATIC CANCER / SUPERPARAMAGNETIC IRON OXIDE
Research Abstract	We examined the retaining in vitro immunoreactivity of superparamagnetic iron oxide (SPIO) bound to Mab A7 and their in vivo distribution in nude mice bearing human pancreatic carcinoma xenografts were examined. A7-SPIO retained binding activities nearly identical to Mab A7. Significantly more of the radiolabeled A7-SPIO and ^<125>I labeled normal mouse IgG-SPIO disappeared from blood rapidly. As for all resected normal tissues, the accumulation levels of ^<125>I labeled A7-SPIO were lower than those for the tumors and decreased linearly with time. In MR imaging of the tumor bearing mude mice, signal intensity was reduced by the injection of A7-SPIO for the tumor

(4 results)