2002 Fiscal Year Final Research Report Summary
STRESS-ACTIVATED SIGNALING IN VASCULAR SMOOTH MUSCLE CELLS DERIVED FROM PATIENTS WITH MOYAMOYA DISEASE
| Project/Area Number |
13671423
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | TOKYO MEDICAL & DENTAL UNIVERSITY, GRADUATE SCHOOL |
|---|
Principal Investigator |
AOYAGI Masaru TOKYO MEDICAL & DENTAL UNIVERSITY, GRADUATE SCHOOL, ASSOCIATE PROFESSOR, 大学院・医歯学総合研究科, 助教授 (40134704)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOSHINO Yoshikazu TOKYO MEDICAL & DENTAL UNIVERSITY, SCHOOL OF MEDICINE, INSTRUCTOR, 医学部附属病院, 助手 (70323681)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Keywords | moyamoya disease / interleukins / muscle, smooth / prostaglandins / vascular endothelial growth factor / p38 mitogen activated kinase |
|---|
| Research Abstract |
Moyamoya disease is a progressive cerebrovascular occlusive disease affecting primarily children. The main vascular leions are stenosis or occlusion with fibrocellular thickening of the intima. The cause remains unknown. We previouly found that cultured smooth muscle cells from moyamoya patients produce excess amounts of prostaglandin E2 in response to interleukin-1 via activation of cyclooxygenase-2, leading to increase in vascular permeability. Here, we demonstrate that moyamoya SMCs highly produce large amounts of vascular endothelial growth factor, a powerful vascular permeability factor as well as an angiogenic factor, by interleukin-1 stimulation. Up-regulated phosphorylation of p38 mitogen-activated kinase followed by activation of cyclooxygenase-2 in moyamoya smooth muscle cells contributed to the excess release of vascular endothelial growth factor and prostaglandin E2 by interleukin-1. Higher responsibility to inflammatory stimuli is a distinct feature of moyamoya smooth muscle cells, causing intimal thickening as well as an enhanced angiogenesis via disordered p38 mitogen-activated kinase phosphorylation machinery.
|
Research Products
(13 results)
-
-
-
-
-
-
-
-
[Publications] Duan L, Aoyagi M, Tamaki M, Nakagawa K, Nagasaka Y, Nagashima G, Ohno, K, Yamamoto, K, Hirakawa K.: "Sensitization of human malignant glioma cell lines to tumor necrosis factor-induced apoptosis by cisplatin"J Neuro-Oncol. 52. 23-36 (2001)
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
[Publications] Morimoto T, Aoyagi M, Tamaki M, Yoshino Y, Hori H, Yano T, Shibata M, Duan L, Ohno K, Hirakawa K, Yamaguchi N.: "Increased levels of tissue endostatin in human malignant gliomas"Clin. Cancer Res.. 8. 2933-2938 (2002)
Description
「研究成果報告書概要(欧文)」より
-
