Interaction between anesthetic agents and ischemic preconditioning in hepatoenteric ischemia reperfusion injury.

2003 Fiscal Year Final Research Report Summary

• Project/Area Number: 13671614
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: KEIO UNIVERSITY
• Principal Investigator: KOTAKE Yoshifumi Keio University, School of Medicine, Assistant professor, 医学部, 講師 (70195733)
• Co-Investigator(Kenkyū-buntansha): MORITA Yoshihisa Keio University, School of Medicine, Instructor, 医学部, 助手 (10276983) ; TAKEDA Junzo Keio University, School of Medicine, Professor, 医学部, 教授 (30101968)
• Project Period (FY): 2001 – 2003
• Keywords: ischemia / reperfusion / preconditioning / liver / rabbit / inflammation

Research Abstract

In this research project, the interaction between anesthetic agents as well as ATP-dependent potassium channel activation and protective effects caused by ischemic preconditioning in hepatosplanchnic organs. We established the partial hepatic ischemia-reperfusion model in anesthetized rabbits and determined the hepatic ischemia-reperfusion injury with microvascular blood flow and galactose clearance. First, we found that isoflurane, volatile anesthetic agent, offered stronger protection compared to intravenous anesthetic, propofol (Am Soc Anesthesiologists, annual meeting A-94, 2002). Second, activation of ATP-dependent potassium channel by nicorandil did not offer signiftcant protection in the liver ischemic injury (Am Soc Anesthesiologists, annual meeting A-721, 2003). These results are either under submission or during preparatory phase for future submission to the English academic journals. Furthermore, the interaction between preconditioning and suppression of neutrophil or Kupffer cell-dependent inflammatory process are under investigation.