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2002 Fiscal Year Final Research Report Summary

Study of the molecular pathology of ADPKD

Research Project

Project/Area Number 13671638
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionKyorin University (2002)
The University of Tokyo (2001)

Principal Investigator

HORIE Shigeo  Kyorin University, School of Medicine, Associate Professor, 医学部, 助教授 (40190243)

Project Period (FY) 2001 – 2002
KeywordsPkd1 / ADPKD / Knock-out mice / microarray
Research Abstract

We analyzed the comprehensive gene expression analysis of Pkd1^%, using cDNA microarray. We extracted the mRNA from E14.5 fetus kidney, and applied mRNA onto DNA chip containing more than 3000 genes. We identified that POLD1 (DNA polymerase delta catalytic subunit-1) was up-regulted in null mice. Interestingly, apoptosis driving genes such as caspase 1, 7, 11 and IL-1b, Transcription factors such as GATA2, Lbx, 1 and jun D1, a cell cycle related gene were down-regulated in null mice. Based on these data, renal cystogenesis involved the defected apoptosis pathway and stimulated cell cycle turnover.

  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] Muto S, Horie S, et al.: "Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant"Hum Mol Genet.. 11(15). 1731-1742 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Muto S., Horie S., et al.: "Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant"Hum Mol Genet. 11(15). 1731-1742 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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