2002 Fiscal Year Final Research Report Summary
Study of molecular pathology of rat model with inherited retinal degeneration
| Project/Area Number |
13671846
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Hirosaki University |
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Principal Investigator |
OHGURO Hiroshi Hirosaki University School of Medicine, Ophthalmology, associate professor, 医学部, 助教授 (30203748)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Ikuyo Hirosaki University School of Medicine, Ophthalmology, assistant professor, 医学部, 講師 (90305235)
NAKAZAWA Mitsuru Hirosaki University School of Medicine, Ophthalmology, professor, 医学部, 教授 (80180272)
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| Project Period (FY) |
2001 – 2002
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| Keywords | retinal degeneration / animal model / retinitis pigmentosa / drug therapy / calcium antagonist / photoreceptor / recoverin / rhodopsin phosphorylation |
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| Research Abstract |
The Royal College of Surgeons (RCS) rat is the most extensively studied animal model for understanding the molecular pathology of inherited retinal degeneration, such as retinitis pigmentosa (RP). Here, purpose of the present study is to evaluate drug effects of several kinds of Ca^<2+> antagonist on the retinal degeneration of RCS rats. Methods : Several kinds of Ca^<2a> antagonists, diltiazem, nicardipine, nilvadipine or niphedipine, were intraperitoneal administrated and thereafter retinal morphology and functions were analyzed. Results : We found that systemic administration of only nilvadipine caused preservation of retinal morphology and functions of electroretinogram resopnses in RCS rats during the initial stage of the retinal degeneration. Studies using immunohistochemistry, RT-PCR and Western blotting revealed significant enhancement of rhodopsin kinase and α-A-crystalline expressions in the retina of nilvadipine treated rats. Based upon these data, it is strongly suggested that nilvadipine is beneficial for the preservation of photoreceptor cells in RCS rats and can potentially be used to treat some RP patients.
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[Publications] Maeda, T., Maeda, A., Maruyama, L., Ogawa, K., Kuroki, Y., Sahara, H., Satoh, N., Ohguro, H.: "Mechanisms of photoreceptor cell death in cancer-associated retinopathy"Invest Ophthalmol Vis Sci. 42. 705-712 (2001)
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[Publications] Maruyama, I., Maeda, T., Okisaka, S., Mizukami, A., Nakazawa, M., Ohguro, H.: "Autoantibody against neron-specific enolase found in glaucoma patients causes retinal dysfunction in vivo"Jpn J Ophthalmol. 46. 1-12 (2002)
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